Germanium

Keith, Larry S.; Maples-Reynolds, Nikki

doi:10.1016/b978-0-12-822946-0.00012-x

Cited by 3 publications

(7 citation statements)

References 154 publications

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“…As of now, low toxicity Ge-132 has been established [ 40 , 52 , 53 , 54 ]. In fact, the toxicity of organic germanium compounds [ 55 , 56 , 57 , 58 , 59 , 60 ] is lower than that of table salt and inorganic germanium dioxide, for which the oral toxicity for mice (LD 50 ) is 5400 mg/kg [ 55 ]. For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD 50 > 6300 mg/kg, oral for rats is >10,000 mg/kg and intravenous toxicity for rats is >1000 mg/kg [ 58 ].…”

Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

“…For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD 50 > 6300 mg/kg, oral for rats is >10,000 mg/kg and intravenous toxicity for rats is >1000 mg/kg [ 58 ]. Germatranol, another common germanium derivative, is also of low toxicity: oral toxicity (LD 50 ) is 8400 mg/kg for mice; intravenous toxicity is 300 mg/kg [ 57 ]. Thus, both inorganic and organic compounds of germanium are perfectly safe in those doses in which they are usually used.…”

Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

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Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and briefly suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and suppressed for a long time.

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Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…As of now, low toxicity Ge-132 has been established [40,[52][53][54]. In fact, the toxicity of organic germanium compounds [55][56][57][58][59][60] is lower than that of table salt and inorganic germanium dioxide, for which the oral toxicity for mice (LD50) is 5400 mg/kg [55]. For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD50 > 6300 mg/kg, oral for rats is >10000 mg/kg and intravenous toxicity for rats is >1000 mg/kg [58].…”

Section: DI Mendeleev (Left) and C Winklermentioning

confidence: 99%

“…For example, for the best-known organic germanium sesquioxide Ge-132 oral toxicity for mice is LD50 > 6300 mg/kg, oral for rats is >10000 mg/kg and intravenous toxicity for rats is >1000 mg/kg [58]. Germatranol, another common germanium derivative, is also of low toxicity: oral toxicity (LD50) is 8400 mg/kg for mice, intravenous toxicity is 300 mg/kg [57]. Thus, both inorganic and organic compounds of germanium are perfectly safe in those doses in which they are usually used.…”

Section: DI Mendeleev (Left) and C Winklermentioning

confidence: 99%

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Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков¹,

Popov²

2023

Preprint

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and hushed up for a long time.

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A Review on Interaction of Nanomaterials of Group-XIV (G14) Elements of the Periodic Table with Proteins and DNA: Applications in Biotechnology and Pharmacy

Hekmat,

Haertlé,

Leblanc

et al. 2024

BioNanoSci.

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Germanium

Cited by 3 publications

References 154 publications

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Physiological Activity of Trace Element Germanium Including Anticancer Properties

A Review on Interaction of Nanomaterials of Group-XIV (G14) Elements of the Periodic Table with Proteins and DNA: Applications in Biotechnology and Pharmacy

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