German Acupuncture Trials (Gerac) For Chronic Low Back Pain&lt;subtitle&gt;Randomized, Multicenter, Blinded, Parallel-Group Trial With 3 Groups&lt;/subtitle&gt;

Haake, M.; Schade‐Brittinger, Carmen; Basler, H.-D.; Maier, Christoph; Endres, Heinz G.; Trampisch, Hans J.; Molsberger, Albrecht

doi:10.1001/archinte.167.17.1892

Cited by 653 publications

(413 citation statements)

References 22 publications

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“…Acupuncture in addition to usual care or another therapy was generally found to ameliorate pain and improve function better than other therapy alone. Finally, again based on a single study, 33 Rubenstein et al concluded that acupuncture was more effective than standard care at improving pain and function at immediate and shortterm follow-up, but only function was improved to a clinically significant degree. 25 Trigkilidas' systematic review was the most recently published, and examined studies from 2005 onward.…”

Section: Systematic Review 4: Yuan Et Al (2008)mentioning

confidence: 99%

Acupuncture in the Treatment of Chronic Low Back Pain

Wong¹

2012

DMJ

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Section: Systematic Review 4: Yuan Et Al (2008)mentioning

confidence: 99%

Acupuncture in the Treatment of Chronic Low Back Pain

Wong¹

2012

DMJ

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“…Patients, even in Western countries, often regard acupuncture as an alternative to the mainstream treatments or as a complementary treatment to be used as an add-on. Due to an increase in its popularity, there has been a recent diversification of acupuncture research away from the more traditional study of pain 3 into the examination of the role of acupuncture in mental disorders. [4][5][6][7][8][9][10][11][12][13] The first foray into the use of acupuncture in the treatment of depression was the investigatory work on electroacupuncture.…”

Section: Introductionmentioning

confidence: 99%

The brain effects of laser acupuncture in depressed individuals: an fMRI investigation

Quah-Smith

Wang

Chen

et al. 2013

Deutsche Zeitschrift für Akupunktur

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Background: The 2010 Cochrane Collaboration Review reported laser acupuncture as being effective in depression. The treatment was on LR 8, LR 14, CV 14, and HT 7 over 12 sessions within a 2-month period. Objective: The aim of this study was to investigate the biological plausibility of low-intensity laser acupuncture as an antidepressant treatment. Design: Randomized stimulation with a fiber-optic infrared laser on these acupoints and KI 3 acupoint. We used a blocked design, alternating laser and placebo laser/rest blocks, while the blood oxygenation leveldependent (BOLD) fMRI response was recorded from the whole brain on a 3T MRI scanner. Setting: This study took place at the research institute. Subjects: Ten subjects were studied, as confirmed by the Hamilton Depression Rating Scale (HAM-D 17 ). Intervention: Low-intensity laser acupuncture. Main outcome measures: Significant brain patterns for each acupoint greater than the other acupoints and placebo. Results: Each acupoint laser stimulation condition resulted in a different activation size and pattern of neural activity. Regions with significantly increased activation and deactivation compared to placebo included frontolimbic-striatal brain regions. There was no significant activation or deactivation with KI 3. Blinding was afforded with the block design and the infrared laser. Conclusions: There is positive biological evidence to support the empirical evidence for laser acupuncture in the treatment of depression. With its minimal adverse effect profile and ease of application, laser acupuncture should be included in depression management strategies.

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“…This paradox, which has been theoretically described and termed the 'efficacy paradox' [44], has recently become reality in two large acupuncture studies [55,56]. Implications for clinical trial methodology need to be discussed [42,44].…”

Section: Introductionmentioning

confidence: 99%

Introduction to placebo effects in medicine: mechanisms and clinical implications

Meißner

Kohls

Colloca

2011

Phil. Trans. R. Soc. B

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The field of placebo research has made considerable progress in the last years and it has become a major focus of interest. We know now that the placebo effect is a real neurobiological phenomenon and that the brain's 'inner pharmacy' is a critical determinant for the occurrence of psychobiological and behavioural changes relevant to healing processes and well-being. However, harnessing the advantages of placebo effects in healthcare is still a challenge. The first part of the theme issue summarizes and discusses the various kinds of placebo mechanisms across medical fields, thereby not only focusing on two main explanatory models-expectation and conditioning theory-but also taking into account empathy and social learning, emotion and motivation, spirituality and the healing ritual. The second part of the issue focuses on questions related to transferring knowledge from placebo research into clinical practice and discusses implications for the design and interpretation of clinical trials, for the therapeutic settings in daily patient care, and for future translational placebo research.

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German Acupuncture Trials (Gerac) For Chronic Low Back Pain<subtitle>Randomized, Multicenter, Blinded, Parallel-Group Trial With 3 Groups</subtitle>

Cited by 653 publications

References 22 publications

Acupuncture in the Treatment of Chronic Low Back Pain

Acupuncture in the Treatment of Chronic Low Back Pain

The brain effects of laser acupuncture in depressed individuals: an fMRI investigation

Introduction to placebo effects in medicine: mechanisms and clinical implications

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