Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity

Cao, Yan; Long, Qun; Zhang, Yundong; Gajendran, Babu; Krishnapriya, M.; Qiu, Jianfei; Song, Jin‐Chao; Rao, Qing; Yi, Ping; Sun, Mao; Li, Yanmei

doi:10.1016/s1875-5364(21)60052-3

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…The genus Carpesium (Asteraceae) contains about 21 species worldwide. 1,2 They are mostly perennial herbs and distributed across Asia and Europe, particularly in the mountainous areas of Southwest China. 3 Many Carpesium plants have been used in traditional medicines for the treatments of fevers, colds, bruises, insect and snake bites in China, Korea, Japan and other Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

Zhang,

Du,

Teng

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

Zhang,

Du,

Teng

et al. 2024

RSC Adv.

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“…It is noteworthy that germacranolides exist as the largest group, which act as biogenetic precursors for the other types of sesquiterpene lactones. Previous investigations revealed the diversity of the pharmacological properties of germacranolides, such as antitumor [ 8 ], anti-inflammatory [ 9 ], antibacterial [ 10 ], cytotoxic [ 11 ], and immune [ 12 ] effects.…”

Section: Introductionmentioning

confidence: 99%

The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity

Yan

Tang

et al. 2023

Molecules

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Artemisia divaricate belongs to the Artemisia genus of the family of Compositae, a sort of perennial herb endemic in most regions of China. For the first time, a phytochemical investigation was carried out on the whole plant of Artemisia divaricate, resulting in the identification of 39 sesquiterpenes, with 9 of them being new (1–9). The structures of the new compounds were fully established using extensive analysis of MS and 1D and 2D NMR spectroscopic data and density functional theory (DFT) NMR calculations. Their structures involve germacrane, eudesmane, and bisabolane types. All the new isolates were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages of RAW 264.7 cells. Compounds 2 and 8 showed a significant inhibition effect on NO production, with IC50 values of 5.35 ± 0.75 and 7.68 ± 0.54 µM, respectively.

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“…Germacranolides are an important class of naturally occurring plant metabolites that possess a distinctive ten-membered molecular core fused with a five-membered γ-lactone and are distributed widely in the family Asteraceae, , i.e., in the genera Elephantopus , − Carpesium , − and Saussurea . Germacranolides have drawn considerable attention due to their structural diversity and demonstrated cytotoxic properties.…”

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confidence: 99%

Highly Oxidized Germacranolides from Elephantopus tomentosus and the Configurational Revision of Some Previously Reported Analogues

Bai

et al. 2022

J. Nat. Prod.

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Highly oxidized germacranolides are mainly found in the genus Elephantopus, contain a characteristic ten-membered molecular core that is highly flexible, and exhibit potential cytotoxic properties. However, their configurations were assigned ambiguously in previous reports due to spectroscopic observation of macrocyclic systems. Herein, 17 highly oxidized germacranolides, including 12 new germacranolides (1−12), were isolated from Elephantopus tomentosus. Their structures were characterized by spectroscopic data analysis combined with X-ray crystallography and ECD calculations, and it was possible to propose configurational revisions of five previously reported analogues (13−17). Cytotoxic activities for 1−17 against two hepatocellular carcinoma cell lines (HepG2 and Hep3B) were tested, and compounds 1−10 and 13−16 generated IC 50 values of 2.2−9.8 μM. Furthermore, the observed cytotoxic activity of 1 was determined as being mediated by inducing the apoptosis of HepG2 and Hep3B cells via mitochondrial dysfunction.

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Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity

Cited by 3 publications

References 32 publications

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity

Highly Oxidized Germacranolides from Elephantopus tomentosus and the Configurational Revision of Some Previously Reported Analogues

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