Germ Cell Tumors of Miscellaneous Extragonadal Sites

Rubio-Fernández, Alejandro; Retamero, Juan Antonio; Nogales, Francisco F.

doi:10.1007/978-3-662-53775-6_11

Cited by 2 publications

(2 citation statements)

References 213 publications

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“…In addition to their relevance for germ cell development, our results appear to be highly relevant for the formation of teratoma, a tumor type found in mice and humans that contains cells of more than one germ layer. These tumors develop within the gonad or at extragonadal sites, with the latter suggested to originate from migrating PGCs on their way to the developing gonad (Gö bel et al, 2000;Looijenga, 2005, 2017;Oosterhuis et al, 2007;Rubio-Ferná ndez et al, 2017;Salz et al, 2017;Schneider et al, 2001). Results relevant for gonadal tumors were described in C. elegans, where germ cells lacking the function of LIN-41 express muscle and neuronal markers (Tocchini et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation

Groß-Thebing¹,

Yigit²,

Pfeiffer³

et al. 2017

Developmental Cell

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Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during embryogenesis, when extensive cell proliferation, patterning, and migration events take place. Here we show that vertebrate primordial germ cells (PGCs) are protected from reprogramming into other cell types by the RNA-binding protein Dead end (Dnd). PGCs knocked down for Dnd lose their characteristic morphology and adopt various somatic cell fates. Concomitantly, they gain a gene expression profile reflecting differentiation into cells of different germ layers, in a process that we could direct by expression of specific cell-fate determinants. Importantly, we visualized these events within live zebrafish embryos, which provide temporal information regarding cell reprogramming. Our results shed light on the mechanisms controlling germ cell fate maintenance and are relevant for the formation of teratoma, a tumor class composed of cells from more than one germ layer.

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Section: Discussionmentioning

confidence: 99%

The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation

Groß-Thebing¹,

Yigit²,

Pfeiffer³

et al. 2017

Developmental Cell

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“…Yolk sac tumours (YSTs; also known as endodermal sinus tumours) are rare, highly malignant non-seminomatous germ cell tumours that typically arise in the gonads of young children aged 1–2 years old 1–3. Pure YSTs are rare in adults as their components are often integrated with elements of embryonal carcinoma and other types of germ cell tumours 4 5…”

Section: Introductionmentioning

confidence: 99%

Pure primary renal yolk sac tumour in an adult: extremely rare clinical finding

2023

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We present a rare case of an extragonadal retroperitoneal yolk sac tumour in an adult male, who presented with severe abdominal pain to his local hospital. Imaging revealed a large retroperitoneal soft tissue mass with no evidence of metastases. Initial biopsy demonstrated poorly differentiated carcinoma, favoured to be renal cell carcinoma. The patient underwent surgical resection following re-presentation with severe abdominal pain and significant interval enlargement of the mass. Laparotomy revealed a renal tumour that had ruptured through the left mesocolon into the peritoneal cavity. Postoperative histopathological examination revealed a yolk sac tumour involving the kidney, perinephric fat, renal sinus fat, renal hilar lymph node and colonic mesentery. Immunohistochemical staining for alpha-fetoprotein and glypican 3 was positive in the tumour cells without evidence of other germ cell elements, confirming the diagnosis of a pure yolk sac tumour. To our knowledge, this is an extremely rare case of a primary pure yolk sac tumour arising from the kidney in an adult.

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Germ Cell Tumors of Miscellaneous Extragonadal Sites

Cited by 2 publications

References 213 publications

The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation

The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation

Pure primary renal yolk sac tumour in an adult: extremely rare clinical finding

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