Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study

Abstract

Our results suggest a high prevalence of impairment across multiple domains of function in SLE patients of all ages, similar to or exceeding the prevalence observed in much older geriatric populations. Further research into the added value of geriatric assessment in routine care for SLE is warranted.

Health service utilization among African American women living with systemic lupus erythematosus: perceived impacts of a self-management intervention

“…Our analysis also revealed that older women were more likely to report post-CDSMP improvements in medication side effect management. Because older age can potentially increase polypharmacy associated with greater cumulative organ damage [46] and contribute to cognitive impairments to perform instrumental self-management activities in the SLE population [47], our findings support the relevance of the CDSMP program to improve drug side effect management among those at higher risk.…”

Patient and provider perceptions of a novel cognitive functioning report for patients with systemic lupus erythematosus: a qualitative study

“…Four 90 min focus groups (two SLE patient (n=18) groups and two SLE provider groups (n=9)) were held in 2019. Patient participants were recruited from the APPEAL pilot, 9 representing a subsample of the population-based Georgians Organized Against Lupus cohort 10 ; provider participants (physicians, nurses, medical assistants) were recruited from the local provider population based on their experience with patients with SLE. While the initial prototype report was created by the study team, without patient involvement, these focus groups were designed to identify patient and provider priorities for the report of cognitive functioning information in future pragmatic research and ultimately clinical care.…”

“…The domains of cognitive functioning included episodic memory, working memory, processing speed, inhibitory control and attention, and cognitive flexibility and were based on the NIH Toolbox 11 assessments that were performed in the APPEAL pilot study. 9 Everyday examples of tasks involving these cognitive domains were listed, discussed and selected by the entire team over the course of several meetings; the chosen examples were illustrated and provided along with a written description ( figure 1 ). To gather feedback on preferred presentation of performance/scores, the hypothetical patient’s performance was displayed as both a colour-gradated scale with categories of ‘impaired’, ‘borderline’, ‘low average’ and ‘average or better’ and as numeric scores, including age, sex, race, ethnicity and education-adjusted t-scores (mean=50, SD=10) with associated percentiles.…”

“…To address this gap, we leveraged our experiences in (1) creating a physical functioning report from a previous study in patients receiving dialysis 8 and (2) completing detailed cognitive assessments as part of a pilot study of functioning in patients with SLE (Approaches to Positive, Patient-centered Experiences of Aging in Lupus; APPEAL) 9 to create a prototype cognitive functioning report for patients with SLE and obtain feedback on the value and presentation of the report. Our objective was to determine whether and how cognitive assessment data should be included in a functioning report for patients with SLE and their providers.…”

The Effects of 10-Week Aerobic-cognitive Combined Training on Serum Levels of High Sensitivity C-reactive Protein, Anti-cardiolipin antibodies, and Mental Status of Female Patients With Lupus Erythematosus Systemic: A Preliminary Study

“…They evaluated their cognitive functions and motor perception. Their results showed lupus inflammation-induced damages in all age ranges, especially at older ages [18].…”