“…Neither have we seen a patient in this latter group who has continued to bleed when treatment has been temporarily discontinued and later reinstituted at a lower individualized dosage level. The question of the so‐called high incidence of uterine malignancy, coexisting with prolonged estrogen elaboration, femininizing ovarian tumors and uterine fibroids, has been most effectively answered by Emge (14). He points out that in a large number of uteri removed by hysterectomy and at autopsy, the coexistence of cancer with such lesions is no greater than that expected by chance.…”
“…Neither have we seen a patient in this latter group who has continued to bleed when treatment has been temporarily discontinued and later reinstituted at a lower individualized dosage level. The question of the so‐called high incidence of uterine malignancy, coexisting with prolonged estrogen elaboration, femininizing ovarian tumors and uterine fibroids, has been most effectively answered by Emge (14). He points out that in a large number of uteri removed by hysterectomy and at autopsy, the coexistence of cancer with such lesions is no greater than that expected by chance.…”
The ratio of the number of cases of cervical cancer to endometrial cancer was found to be 6.7/1 in one hospital, while at another hospital in the same city, but a few miles away, the ratio was 1.1/1.
The incidence of mammary and genital cancer was investigated in a group of 304 women whose ages ranged from 40 to 70 years (average 50.8) and who were treated with exogenous estrogens for periods up to 27 years (average 7.8). The breasts were thus exposed to estrogen for 2,387 patient-years. The
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.