Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease

Bagheri, Shokufeh; Rashno, Masome; Salehi, Iraj; Karimi, Seyed Asaad; Raoufi, Safoura; Komaki‬, Alireza

doi:10.1016/j.ejphar.2023.175714

Cited by 7 publications

(4 citation statements)

References 69 publications

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Section: Introductionmentioning

confidence: 90%

“…Derivatives of diol 1, compounds 3 and 4, showed neuroprotective effects in vitro and in several experimental mice models (MPTP-, rotenone-, and haloperidol-induced) of Parkinson's disease [66,67] (Figure 2). Neuroprotective potential was demonstrated also for carvacrol [68][69][70], limonene [71][72][73], geraniol [74,75], citronellol [76], carveol [77], 1,8-cineole [78], paeoniflorin [79], α-pinene [80], and linalool [81]. Guzmán-Gutiérrez et al (2012) reported an antidepressant effect of β-pinene and linalool [82], and Deng et al (2015) found that thymol demonstrated this property in a model of chronic mild stress in mice [83].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Dragomanova,

Andonova,

Volcho

et al. 2023

Life

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The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability to exhibit a wide range in biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vasodilating properties. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing effects in experimental dementia and Parkinson’s disease. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive avenue within experimental pharmacology, offering a promising approach for the therapy of diverse pathological conditions. Biologically active substances such as monoterpenes, for example, borneol, camphor, geraniol, pinene, and thymol, are used to synthesize compounds with analgesic, anti-inflammatory, anticonvulsive, antidepressant, anti-Alzheimer’s, antiparkinsonian, antiviral and antibacterial (antituberculosis) properties. Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, the conjugation of myrtenal with the established pharmacophore adamantane enables the augmentation of several of its pivotal properties. Myrtenal–adamantane derivatives exhibited a variety of beneficial characteristics, such as antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective properties, which are worth examining in more detail and at length.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Dragomanova,

Andonova,

Volcho

et al. 2023

Life

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“…Memory-enhancing properties have also been reported for some of the monoterpenes studied 2). Neuroprotective potential was demonstrated also for carvacrol [68][69][70], limonene [71][72][73], geraniol [74,75], citronellol [76], carveol [77], 1,8-cineole [78], paeoniflorin [79], αpinene [80], and linalool [81]. Guzmán-Gutiérrez et al (2012) reported the antidepressant effect of β-pinene and linalool [82], and Deng et al (2015) found that thymol demonstrated such properties in a model of chronic mild stress in mice [83].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Myrtenal and Its Derivatives–A Review

Dragomanova,

Andonova,

Volcho

et al. 2023

Preprint

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Monoterpenes as natural products are the subject of increased attention in the search for new pharmacological agents because of their numerous biological activities including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, vasodilating effects, etc. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing in experimental dementia and Parkinson’s disease effects. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive direction in experimental pharmacology and a promising approach to the therapy of various pathologies. Biologically active substances such as monoterpenes borneol, camphor, geraniol, pinene, and thymol, were used to synthesize compounds with different properties, including analgesic, anti-inflammatory, anticonvulsant, anti-depressant, anti-Alzheimer’s, anti-parkinsonian, antiviral and antibacterial (anti-tuberculosis). Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, conjugation of myrtenal with the known pharmacophore adamantane allows one to enhance some of its key properties. Myrtenal-adamantane derivatives exhibited a variety of beneficial properties – antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective, which are worth examining in more detail and at length.

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“…The reduction of antioxidants or accumulation of free radicals like reactive oxygen species (ROS) in cells during oxidative stress ultimately leads to the damage of cellular functions and cell death in the central nervous system of affected individuals ( Birben et al, 2012 ). Although none of the existing models of AD completely replicate the human disease, Aβ-induced AD is used as a well-defined model to identify the underlying pathophysiological mechanisms of AD ( Arabi et al, 2023 ; Bagheri et al, 2023 ). Previous research workers have highlighted that Aβ peptides result in disrupted synaptic plasticity in the hippocampus and impairment of learning and memory, and as a result, there is cognitive decline ( Ahmadi et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Cacao consumption improves passive avoidance memory impairment in a rat model of Alzheimer’s disease: the role of hippocampal synaptic plasticity and oxidative stress

Basir,

Mirazi,

Komaki

et al. 2024

Front. Pharmacol.

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Introduction: Alzheimer’s disease (AD) causes progressive loss of cognitive function and synaptic plasticity, which is the most common form of dementia. The present study was designed to scrutinize the effects of cacao on passive avoidance memory function and to identify the roles of hippocampal synaptic plasticity and oxidative stress in an AD rat model induced by unilateral intracerebroventricular (UICV) injection of amyloid-beta (Aβ).Methods: Oral administration of cacao (500 mg/kg/ day) was given for 2 consecutive months. A memory retention test was conducted 24 h after passive avoidance training was completed. Subsequently, the amplitude of population spike (PS) and slope of field excitatory postsynaptic potentials (fEPSPs) were assessed at hippocampal long-term potentiation (LTP) in perforant pathway–dentate gyrus (PP-DG) synapses. Moreover, total thiol group (TTG) and malondialdehyde (MDA) concentrations were evaluated in the plasma. Furthermore, compact Aβ plaques were detected in the hippocampal DG by performing Congo red staining.Results: As a result of AD induction, passive avoidance memory was impaired; also, reduced fEPSP slopes, PS amplitudes, and content of TTG, and increase in MDA levels in the rats were observed. In contrast, cacao treatment ameliorated passive avoidance memory impairment, improved hippocampal LTP impairment, modulated oxidative–antioxidative status, and delayed Aβ plaques production in AD rats.Disscussion: Conclusively, cacao alleviates Aβ-induced cognitive deficit, probably by the amelioration of hippocampal LTP impairment, modulation of oxidative–antioxidative status, and inhibition of Aβ plaque accumulation

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Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease

Cited by 7 publications

References 69 publications

Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Therapeutic Potential of Myrtenal and Its Derivatives–A Review

Cacao consumption improves passive avoidance memory impairment in a rat model of Alzheimer’s disease: the role of hippocampal synaptic plasticity and oxidative stress

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