Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner

Rekha, Karamkolly R.; Selvakumar, Govindasamy P.; Santha, K; Sivakamasundari, Ramu Inmozhi

doi:10.1016/j.bbrc.2013.09.122

Cited by 31 publications

(16 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, chronic MPTP treatment can induce α ‐synuclein oligomerization and such oligomers produce most pathological actions of α ‐synuclein, including mediating neuronal death and motor dysfunction . In addition, MPTP application markedly increases α ‐synuclein expression in the animal model of PD , and the overexpression of α ‐synuclein causes oxidative stress and mitochondrial structural abnormalities . Importantly, we here also found that chronic DHF treatment significantly inhibited MPTP‐induced α ‐synuclein overexpression, which may reduce oxidative stress and mitochondrial dysfunction, thereby contributing to the amelioration of motor function.…”

Section: Discussionsupporting

confidence: 59%

7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α‐synuclein Expression and Oxidative Stress in the MPTP‐induced Mouse Model of Parkinson's Disease

Dai

Chen

et al. 2016

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 59%

7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α‐synuclein Expression and Oxidative Stress in the MPTP‐induced Mouse Model of Parkinson's Disease

Dai

Chen

et al. 2016

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…The depleted levels of DA among diabetic rats were restored in the SN and the brain region Ct and St with GE supplementation, emphasizing its antihypersensitivity effect in pain assessment tests, such as hyperalgesia and allodynia. The restorative effect of GE has been demonstrated previously in an MPTP neurotoxicity model in mice (Rekha et al, ). We also found elevated DA levels in Drosophila melanogaster coexposed to acrylamide by GE (Prasad and Muralidhara, ).…”

Section: Discussionmentioning

confidence: 62%

Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: Attenuation of behavioral impairments and biochemical perturbations

Prasad

Muralidhara

2014

J of Neuroscience Research

View full text Add to dashboard Cite

Involvement of oxidative stress, inflammatory response, and mitochondrial dysfunction in the development of diabetic neuropathy (DN) is well appreciated. The present study examines the potential of geraniol (GE), a well-known phytoconstituent commonly found in lemon, spices, rose oil, etc., to attenuate DN-associated oxidative/nitrosative stress by employing a streptozotocin (STZ) diabetic rat model. STZ-induced diabetic rats provided with oral supplements of GE (100 mg/kg bw/day, 8 weeks) exhibited significant improvement in tail-flick latency (sensory function) and the narrow beam test (motor function). Terminally, elevated levels of oxidative markers (reactive oxygen species, malondialdehyde, hydroperoxides) in cytosol of the sciatic nerve (SN) and in selected regions of the brain of diabetic rats were markedly reduced by GE supplements. Furthermore, GE significantly diminished the levels of protein carbonyls (a measure of protein oxidation) and nitrites in diabetic rats. In addition, in mitochondria, GE supplements restored the activities of enzymes, such as complexes I-III, succinate dehydrogenase, and citrate synthase, in brain regions of diabetic rats, with a concomitant reduction in the levels of oxidative markers. GE significantly lowered the enhanced cytosolic calcium levels and acetylcholinesterase activity in the SN and the brain regions of diabetic rats. Depleted dopamine levels evident in the SN and the cortex/striatum among diabetic rats were restored by GE. From our data, we hypothesize that GE may be a promising therapeutic candidate in the management of DN in humans. Further understanding of the molecular mechanisms of its neuromodulatory effects is essential in order to exploit its therapeutic efficacy.

show abstract

“…Also, Rekha et al in another study stated that administration of geraniol prior to the induction of Parkinsonism had improved neuromuscular malfunction and tyrosine hydroxylase expression in a dose dependant manner. In addition, it decreased α-synuclein expression [66].…”

Section: Pharmacological Studymentioning

confidence: 94%

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

et al. 2020

View full text Add to dashboard Cite

Brain damage caused by cerebral ischaemia/reperfusion (I/R) can lead to handicapping. So, the present study aims to evaluate the prophylactic and therapeutic effects of geraniol in the form of intranasal polymeric mixed micelle (PMM) on the central nervous system in cerebral ischaemia/reperfusion (I/R) injury. A 32 factorial design was used to prepare and optimize geraniol PMM to investigate polymer and stabilizer different concentrations on particle size (PS) and percent entrapment efficiency (%EE). F3 possessing the highest desirability value (0.96), with a PS value of 32.46 ± 0.64 nm, EE of 97.85 ± 1.90%, and release efficiency of 59.66 ± 0.64%, was selected for further pharmacological and histopathological studies. In the prophylactic study, animals were classified into a sham-operated group, a positive control group for which I/R was done without treatment, and treated groups that received vehicle (plain micelles), geraniol oil, and geraniol micelles intranasally before and after I/R. In the therapeutic study, treated rats received geraniol oil and micelles after I/R. Evaluation of the effect of geraniol on behavior was done by activity cage and rotarod and the analgesic effect tested by hot plate. Anti-inflammatory activity was assessed by measuring interleukin β6, cyclooxygenase-2, hydrogen peroxide, and inducible nitric oxide synthase. Histopathogical examination of cerebral cortices was also done to confirm the results of a biochemical assay. Geraniol nanostructured polymeric mixed micelles showed an enhanced neuro-protective effect compared to geraniol oil, confirming that PMM via intranasal route could be an efficient approach for delivering geraniol directly to the brain through crossing the blood–brain barrier.

show abstract

Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner

Cited by 31 publications

References 51 publications

7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α‐synuclein Expression and Oxidative Stress in the MPTP‐induced Mouse Model of Parkinson's Disease

7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α‐synuclein Expression and Oxidative Stress in the MPTP‐induced Mouse Model of Parkinson's Disease

Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: Attenuation of behavioral impairments and biochemical perturbations

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion

Contact Info

Product

Resources

About