Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-κB signaling pathway

Jayachandran, Muthukumaran; Chandrasekaran, Balaji; Nalini, Namasivayam

doi:10.1016/j.ejphar.2015.05.039

Cited by 28 publications

(17 citation statements)

References 25 publications

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“…In Mohamed Nadjib Boukhatem and colleagues' study [44], essential oil of rose geranium (RGEO), whose major components were citronellol (29.13%), GE (12.62%), and citronellyl formate (8.06%), was administered orally in three different doses to mice, 10, 100, or 1,000 mg/kg and the results indicated that RGEO might have significant potential for the development of novel anti-inflammatory drugs with improved safety profile. Muthukumaran and colleagues' study [45] showed that A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 15 chronically treatment with GE (100 mg/kg) for 12 weeks on animals did not significantly activate the key inflammatory cytokine, NF-κB in liver, heart and aorta tissues. Considering the relative safety of GE which has already been considered and proved in many previous researches, we spent much effort further in investigating the alleviative effects of GE in pathological conditions so as to support the treatment effects of GE and provide scientific supports for the widely usage of GE clinically.…”

Section: Discussionmentioning

confidence: 96%

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Deng

Xue

et al. 2015

Physiology & Behavior

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Section: Discussionmentioning

confidence: 96%

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Deng

Xue

et al. 2015

Physiology & Behavior

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“…Stephen et al reported that oxidative events also alter the behavior of collagen fibers, increasing their stiffness (43). Dietary fat that increases lipid peroxidation might also nurture the aortic remodeling through enhanced inflammatory reaction (44). …”

Section: Discussionmentioning

confidence: 99%

High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

et al. 2017

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AimMillions of people die each year due to cardiovascular disease (CVD). A Western lifestyle not only fuses a significant intake of fat with physical inactivity and obesity but also promotes CVD. Recent evidence suggests that dietary fat intake impairs the benefits of physical training. We investigated whether aerobic training could reverse the adverse effects of a high-fat diet (HFD) on the aorta. Then, we explored whether this type of exercise could reverse the damage to the heart that is imposed by fat-enriched diet (FED).MethodsRats were randomly assigned to two experiments, which lasted 8 weeks each. First, rats swam for 60 min and were fed either a regular diet [standard diet (STD)] or an HFD. After aortic samples had been collected, the rats underwent a histopathological analysis for different biomarkers. Another experiment subjected rats that were fed either an STD or an FED to swimming for 20 or 90 min.ResultsThe first experiment revealed that rats that were subjected to an HFD-endured increased oxidative damage in the aorta that exercises could not counteract. Together with increased cyclooxygenase 2 expression, an HFD in combination with physical training increased the number of macrophages. A reduction in collagen fibers with an increased number of positive α-actin cells and expression of matrix metalloproteinase-2 occurred concomitantly. Upon analyzing the second experiment, we found that physically training rats that were given an FED for 90 min/day decreased the cardiac adipose tissue density, although it did not protect the heart from fat-induced oxidative damage. Even though the physical training lowered cholesterol levels that were promoted by the FED, the levels were still higher than those in the animals that were given an STD. Feeding rats an FED impaired the swimming protocol’s effects on lowering triglyceride concentration. Additionally, exercise was unable to reverse the fat-induced deregulation in hepatic antioxidant and lipid peroxidation activities.ConclusionOur findings reveal that an increased intake of fat undermines the potential benefits of physical exercise on the heart and the aorta.

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“…8 Furthermore, it was found that treatment with geraniol counteracted the hyperlipidemia, improved endothelial function, and prevented fibrosis in experimental hyperlipidemic hamsters. [9][10][11] In addition, treatment with geraniol attenuated nimesulide-induced hepatotoxicity in rats. 12 Rodents fed with a methionine-choline-deficient (MCD) diet develop a steatohepatitis producing hepatic lesions and changes in liver redox balance, which mimics the impairment observed in patients with NASH.…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that geraniol ameliorated fructose‐induced metabolic syndrome, reduced serum transaminases, and attenuated hepatic malondialdehyde (MDA) formation . Furthermore, it was found that treatment with geraniol counteracted the hyperlipidemia, improved endothelial function, and prevented fibrosis in experimental hyperlipidemic hamsters . In addition, treatment with geraniol attenuated nimesulide‐induced hepatotoxicity in rats …”

Section: Introductionmentioning

confidence: 99%

Treatment with geraniol ameliorates methionine‐choline‐deficient diet‐induced non‐alcoholic steatohepatitis in rats

Fan

Zhou

Gao

2016

J of Gastro and Hepatol

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Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-κB signaling pathway

Cited by 28 publications

References 25 publications

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

Treatment with geraniol ameliorates methionine‐choline‐deficient diet‐induced non‐alcoholic steatohepatitis in rats

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