Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways

Soubh, Ayman A.; Abdallah, Dalaal M.; El‐Abhar, Hanan S.

doi:10.1016/j.lfs.2015.07.004

Cited by 54 publications

(47 citation statements)

References 61 publications

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“…In our study, the phosphodiesterase inhibitor amended much of the macroscopic changes associated with the use of TNBS; it increased CMI and diminished TNBS‐induced colonic ulceration, necrosis, and severe colonic edema. These structural changes were provoked by the use of TNBS to concur with earlier reports . The effect of CS, especially the high dose, showed an effect akin to the standard chosen drug, whereas the best effect was by the low dose tested when added to the standard drug used.…”

Section: Discussionsupporting

confidence: 90%

“…These structural changes were provoked by the use of TNBS to concur with earlier reports. 25 The effect of CS, especially the high dose, showed an effect akin to the standard chosen drug, whereas the best effect was by the low dose tested when added to the standard drug used. CS has previously demonstrated its antiulcerogenic effect in a gastric ulcer model.…”

Section: Discussionmentioning

confidence: 98%

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Cilostazol against 2,4,6‐trinitrobenzene sulfonic acid‐induced colitis: Effect on tight junction, inflammation, and apoptosis

Al‐Kishali

Fattah

Mohammad³

et al. 2019

JGH Open

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Background Inflammatory bowel diseases are immunologically mediated disorders of gastrointestinal tract, characterized by dysregulated immune responses that result in a chronic intestinal inflammation. The antiplatelet cilostazol (CS), a phosphodiesterase‐III inhibitor, exerted a beneficial effect on several models of gastrointestinal diseases; however, the full mechanism of action in this context has not been unveiled. Aim The current study aimed to elucidate the potential role of CS in a 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitis model. Methods Male Wistar rats were divided into a sham group and groups treated with sulfasalazine (500 mg/kg), CS (50 and 100 mg/kg), and a combination (sulfasalazine/CS 50 mg/kg). All treatments were administered orally 15 days, with TNBS rectal administration on the 11th day. Results TNBS‐produced colitis manifested as a decrease in the epithelial junctional adhesion molecule‐A (JAM‐A) and as an increase in trefoil factor‐3, ulcerative area, and colon mass index, parameters that collaborate with the gross macroscopic changes in colon tissue. In addition, TNBS increased hemeoxygenase‐1, nuclear factor‐kappa B, P‐selectin, and myeloperoxidase, as well as the apoptotic ratio of Bax/Bcl‐2. Administration of CS alone, especially at the high dose level, attenuated the severity of TNBS‐induced colitis in a sulfasalazine‐comparable manner. In addition, a better effect was mediated by the combination regimen, which succeeded in normalizing most of the measured parameters. Conclusion CS protected the colon against TNBS through its anti‐inflammatory and antiapoptotic effects along with maintaining cellular tight junctions (TJs). Furthermore, CS can be beneficial as an add‐on drug with the conventional treatments of colitis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Cilostazol against 2,4,6‐trinitrobenzene sulfonic acid‐induced colitis: Effect on tight junction, inflammation, and apoptosis

Al‐Kishali

Fattah

Mohammad³

et al. 2019

JGH Open

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“…There are many reports showing that butyrate is effective at alleviating the burdens inflicted by colitis, particularly through mechanisms that include increases in antimicrobial peptides (AMPs) and mucus production (61)(62)(63)(64). More recently, the PPARG signaling pathways (e.g., NF-κB and MAPK) have become a target for amelioration of colitis, and findings suggest that this receptor activation negatively regulates key inflammatory mediators (65)(66)(67). In the current study, I3C and NaB were able to significantly increase transcript expression of this receptor in the colon.…”

Section: Discussionmentioning

confidence: 99%

Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22–dependent manner

Busbee¹,

Menzel²,

Alrafas³

et al. 2020

JCI Insight

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“…Interestingly, treatment with geraniol reduced clinical signals, oxidative stress, and inflammation associated with colitis induced by TNBS in rats. It also modulated the expression of caspase-3, intercellular adhesion molecule-1, and glycogen synthase kinase-3β as well as the β-catenin, p38 MAPK, NF-κB, and peroxisome proliferator-activated receptor γ signaling pathways in the same way as did sulfasalazine [92]. In addition, treatment with geraniol reversed DSS-induced inflammation and oxidative alterations [93].…”

Section: Family Rosaceaementioning

confidence: 82%

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

et al. 2017

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Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using ?medicinal plants? and ?ulcerative colitis? as key words. Sixty-eight studies were included, and the families Asteraceae and Lamiaceae presented the largest number of studies, but plants from several other families were cited; many of them have shown good results in experimental animals. However, only a few species (such as Andrographis paniculata and Punica granatum) have undergone clinical tests against ulcerative colitis, and the observation that many preclinical studies reviewed are purely descriptive has certainly contributed to this fact. Chemical constituents (mainly flavonoids and terpenes) seem to play a role in the effects of the plants. Thus, the data herein reviewed reinforce the potential of medicinal plants as a source of alternative approaches to the treatment of ulcerative colitis.

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Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways

Cited by 54 publications

References 61 publications

Cilostazol against 2,4,6‐trinitrobenzene sulfonic acid‐induced colitis: Effect on tight junction, inflammation, and apoptosis

Cilostazol against 2,4,6‐trinitrobenzene sulfonic acid‐induced colitis: Effect on tight junction, inflammation, and apoptosis

Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22–dependent manner

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

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