Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages

Arnida,; Janat-Amsbury, Margit-M; Ray, Abhijit; Peterson, Charles M.; Ghandehari, Hamidreza

doi:10.1016/j.ejpb.2010.11.010

Cited by 477 publications

(350 citation statements)

References 45 publications

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“…Hall et al reported a change in AuNP average diameter measured using DLS from 28.2 to 48.5 nm with the addition of a PEG coating. Takae et al observed an increase in nanoparticle diameter from 20 to 33.3 nm after functionalization with 6,000 M w PEG, whereas Arinda et al found that functionalization with 5,000 M w PEG increased AuNP diameter from 50 to 89 nm [30]. In the case of AuNP functionalized with 550 M w PEG, Oh et al reported that the average diameter from DLS was some 6-9 nm higher than that measured using TEM.…”

Section: Resultsmentioning

confidence: 91%

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

et al. 2011

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Thiol-terminated polyethylene glycol (PEG) is commonly used to functionalize the surface of gold nanoparticles (AuNPs) in order to improve their in vivo stability and to avoid uptake by the reticular endothelial system. Although it has been reported that AuNPs functionalized with tethered PEG are stable in biological media, the influence of chain density remains unclear. This study investigates the influence of PEG capping density on the stability of washed and dried AuNPs in: water, phosphate-buffered saline solution (PBS), phosphate-buffered saline solution containing bovine serum albumin (PBS/BSA), and dichloromethane (DCM). PEG coating had a dramatic effect on stability enabling stable suspensions to be produced in all the media studied. A linear relationship was observed between capping density and stability in water and DCM with a somewhat lower stability observed in PBS and PBS/BSA. A maximum PEG loading level of ∼14 wt.% was achieved, equivalent to a PEG surface density of ∼1.13 chains/nm 2 .

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Section: Resultsmentioning

confidence: 91%

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

et al. 2011

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“…At the nanoscale, rod-shaped particles have been shown to exhibit higher cellular internalization (38) and such particles have been shown to exhibit excellent targeting in tumor xenografts (45). Iron oxide nanoworms and gold nanorods have been shown to induce higher tumor accumulation (46,47), and gold nanorods have been shown to exhibit reduced macrophage clearance (48). Recent studies also showed the ability of rodshaped particles to bind specifically to cancer cells in vitro (49).…”

Section: Discussionmentioning

confidence: 99%

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

Kolhar

Anselmo²,

Gupta³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

580

507

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Vascular endothelium offers a variety of therapeutic targets for the treatment of cancer, cardiovascular diseases, inflammation, and oxidative stress. Significant research has been focused on developing agents to target the endothelium in diseased tissues. This includes identification of antibodies against adhesion molecules and neovascular expression markers or peptides discovered using phage display. Such targeting molecules also have been used to deliver nanoparticles to the endothelium of the diseased tissue. Here we report, based on in vitro and in vivo studies, that the specificity of endothelial targeting can be enhanced further by engineering the shape of ligand-displaying nanoparticles. In vitro studies performed using microfluidic systems that mimic the vasculature (synthetic microvascular networks) showed that rodshaped nanoparticles exhibit higher specific and lower nonspecific accumulation under flow at the target compared with their spherical counterparts. Mathematical modeling of particle-surface interactions suggests that the higher avidity and specificity of nanorods originate from the balance of polyvalent interactions that favor adhesion and entropic losses as well as shear-induced detachment that reduce binding. In vivo experiments in mice confirmed that shape-induced enhancement of vascular targeting is also observed under physiological conditions in lungs and brain for nanoparticles displaying anti-intracellular adhesion molecule 1 and anti-transferrin receptor antibodies.biodistribution | morphology | SMN | cylinder | drug delivery

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“…Having administered AuNPs to mice p.o., Zhang et al (2010) observed a decrease in the erythrocyte count as well as the presence of nanoparticles on the surface of cellular membranes and in vesicles inside blood and marrow cells. Also, after intravenous application, gold nanoparticles have been detected in the cellular fraction of the peripheral blood of rats and in the bone marrow of mice (Arnida et al 2011, Hirn et al 2011. These observations may suggest that AuNPs affect hematopoesis and the functions of peripheral blood leukocytes.…”

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confidence: 72%

“…However, gold nanoparticles have also been found in other tissues, mainly inside phagocytes. Macrophage stimulation can contribute to the development of a systemic immune response, but before they reach target organs, AuNPs enter the bloodstream, where they can react with blood cells (Hillyer et al 2001, Sadauskas et al 2007, Sonavane et al 2008, Balasubramanian et al 2010, Lasagna-Reeves et al 2010, Arnida et al 2011, Hirn et al 2011, Thakor et al 2011, Chen et al 2013. Having administered AuNPs to mice p.o., Zhang et al (2010) observed a decrease in the erythrocyte count as well as the presence of nanoparticles on the surface of cellular membranes and in vesicles inside blood and marrow cells.…”

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confidence: 99%

Effect of oral administration of commercial gold nanocolloid on peripheral blood leukocytes in mice

Małaczewska¹

2015

Polish Journal of Veterinary Sciences

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During the last few decades, owing to their unique properties, gold nanoparticles (AuNPs) have found numerous biomedical applications. Studies on rodents prove that AuNPs entering an organism easily reach the bloodstream and undergo wide tissue distribution. The presence of nanoparticles inside blood and bone marrow cells of exposed animals may implicate its influence on hematopoesis and the functions of peripheral blood leukocytes.The aim of this study was to determine the effect of oral administration of commercial gold nanocolloid, recommended by the producer as a dietary supplement, on the percentage of lymphocyte populations and proliferative response, as well as the activity of phagocytes in the peripheral blood of mice. The colloid was given to the animals in three different doses (0.25, 2.5, 25 ppm), for three different time periods (7, 14, 28 days). Mice given nanoparticles showed increased activity of phagocytes and some changes in the lymphocyte phenotypes. The elevated activity of granulocytes and monocytes, in terms of both phagocytic and respiratory burst activity, was transient and noticed only after a short time of administration, which may indicate some adaptability of blood phagocytes to prolonged presence of gold nanoparticles in the body. However, phenotypic modifications among lymphocytes in the group of animals given the middle dose of colloid (i.e. increased percentage of B and CD4+CD8+ DP T cells) did not occur until after the 28-day administration, which in turn seems indicative of some immune dysregulation due to the prolonged contact with nanogold.

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Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages

Cited by 477 publications

References 45 publications

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

Effect of oral administration of commercial gold nanocolloid on peripheral blood leukocytes in mice

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