Abstract:Background
The sina qua non of IBC is numerous tumor emboli especially within dermal lymphatics. The explanation remains a mystery.
Methods
In observational human studies comparing IBC with non-IBC, although common tumor parameters such as Ki-67 index, mitotic count and nuclear size showed a reasonable overlap, there was a dramatic exponential or geometric difference in embolic density and a significant difference in embolic size distribution in IBC v non-IBC. In companion experimental studies using contrast… Show more
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