Geometric parameters on MRA source images to differentiate small Proximal Posterior communicating artery aneurysms from Infundibular dilation

Kim, Yun Ji; Yoon, Dae Young; Kim, Eun Soo; Yun, Eun Joo; Jeon, Hong Jun; Lee, Jong‐Young; Cho, Byung-Moon

doi:10.1111/jon.12846

Cited by 1 publication

(1 citation statement)

References 22 publications

(38 reference statements)

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“…The diagnosis of ICAN was made by at least three physicians (two neurosurgeons and one radiologist), and both magnetic resonance angiography (MRA) and three-dimensional computed tomographic angiography (3DCTA) were mandatory. Infundibular dilatation [12] in the ICA was difficult to diagnose by MRA and 3DCTA alone when the size was < 4 mm. Hence, cerebral angiography or surgical findings by craniotomy were mandatory for the diagnosis of ICAN in this study.…”

Section: Diagnosismentioning

confidence: 93%

RNF213 c.14576G>A Is Associated with Intracranial Internal Carotid Artery Saccular Aneurysms

Murai

Ishisaka

Watanabe

et al. 2021

Genes

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A mutation in RNF213 (c.14576G>A), a gene associated with moyamoya disease (>80%), plays a role in terminal internal carotid artery (ICA) stenosis (>15%) (ICS). Studies on RNF213 and cerebral aneurysms (AN), which did not focus on the site of origin or morphology, could not elucidate the relationship between the two. However, a report suggested a relationship between RNF213 and AN in French-Canadians. Here, we investigated the relationship between ICA saccular aneurysm (ICA-AN) and RNF213. We analyzed RNF213 expression in subjects with ICA-AN and atherosclerotic ICS. Cases with a family history of moyamoya disease were excluded. AN smaller than 4 mm were confirmed as AN only by surgical or angiographic findings. RNF213 was detected in 12.2% of patients with ICA-AN and 13.6% of patients with ICS; patients with ICA-AN and ICS had a similar risk of RNF213 mutation expression (odds ratio, 0.884; 95% confidence interval, 0.199–3.91; p = 0.871). The relationship between ICA-AN and RNF213 (c.14576G>A) was not correlated with the location of the ICA and bifurcation, presence of rupture, or multiplicity. When the etiology and location of AN were more restricted, the incidence of RNF213 mutations in ICA-AN was higher than that reported in previous studies. Our results suggest that strict maternal vessel selection and pathological selection of AN morphology may reveal an association between genetic mutations and ICA-AN development. The results of this study may form a basis for further research on systemic vascular diseases, in which the RNF213 (c.14576G>A) mutation has been implicated.

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Section: Diagnosismentioning

confidence: 93%