2018
DOI: 10.1088/1361-6439/aab1c3
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Geometric optimization of microreactor chambers to increase the homogeneity of the velocity field

Abstract: In this work microfluidic flow-through chambers are investigated. They are filled with magnetic nanoparticle (MNP) suspension in order to facilitate enzymatic reactions. The enzyme is immobilized on the surface of the MNPs. These reactions have been found to be flow rate dependent. To overcome this issue various chamber geometries have been examined and optimized geometries have been designed and tested experimentally. The investigation is supported with dedicated CFD simulations using the open source software… Show more

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Cited by 10 publications
(3 citation statements)
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References 16 publications
(37 reference statements)
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“…which represents the momentum transfer between the two phases. The magnetic force density of the neodymium magnet on the aggregate phase can be determined from the particle magnetic force, which was shown in Equation (5). Based on this equation and the magnetic moment formula in Equation (2) the magnetic force density is…”
Section: Governing Equationsmentioning
confidence: 99%
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“…which represents the momentum transfer between the two phases. The magnetic force density of the neodymium magnet on the aggregate phase can be determined from the particle magnetic force, which was shown in Equation (5). Based on this equation and the magnetic moment formula in Equation (2) the magnetic force density is…”
Section: Governing Equationsmentioning
confidence: 99%
“…The most interesting among them is the catalytic reaction rate dependency on the flow rate [4]. In [5] it is presented that when the microreactor is not fully packed with MNPs, the flow goes around the chemically active aggregate, which creates a bypass for the reagents outside the MNP aggregated phase. This is an undesired effect, as only a part of the reagents participate in the reaction.…”
Section: Introductionmentioning
confidence: 99%
“…This type of coupling is exemplified in the papers selected for this Special Issue. For example, thermal effects on biological lab-on chip devices are discussed in [2], the thermomechanical coupling and the Joule effect play a central role in the thermally actuated switchers that are the subject of [3], coupling between optics and mechanics can be found in the study of micro-optical pressure sensors in [4], electro-mechanical piezoelectric behavior and coupling between mechanical vibration and acoustic signals are fundamental in the PMUT devices described in [6], magnetic fields are used in microreactors in [7]. These diverse effects provide an incomplete but representative picture of the kinds of physical interactions encountered in the field of MEMS and NEMS.…”
mentioning
confidence: 99%