The entanglement entropy (EE) encodes key properties of quantum many-body systems. It is usually calculated for a subregion of finite volume (or area in 2d). In this work, we study the EE of skeletal regions that have no volume, such as a line in 2d/3d. We show that skeletal entanglement displays new behavior compared to its bulk counterpart, and leads to distinct universal quantities. We provide non-perturbative bounds for the skeletal area-law coefficient of a large family of quantum states. We then explore skeletal scaling for the toric code, conformal bosons and Dirac fermions, Lifshitz critical points, and Fermi liquids. We discover signatures including skeletal topological EE, novel bulk and boundary cusp terms, and strict area-law scaling for metals. We discuss the possibility of a continuum description involving the fusion of extended defect operators. Finally, we outline open questions relating to other systems, and measures such as the logarithmic negativity.