Geometric anisotropy on biomaterials surface for vascular scaffold design: engineering and biological advances

Wang, Zuyong; Zhang, Wanqi; Xie, Chao; Wen, Feng; Lin, Nan; Thian, Eng San; Wang, Xianwei

doi:10.1088/2515-7639/ab1c68

Cited by 11 publications

(7 citation statements)

References 94 publications

(124 reference statements)

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“…Electrospinning is a commonly used technology for producing fiber/nanofiber membranes and has been widely used in tissue engineering, filtration systems, flexible electronics, etc. [ 1 , 2 , 3 , 4 , 5 , 6 ]. Many electrospinning fiber membranes (e.g., polyvinyl alcohol (PVA), poly (lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), polysulfone (PSF), polyvinylpyrrolidone (PVP), poly-ε-caprolactone (PCL)) shrink under certain conditions, e.g., upon heating and/or immersing in a right solvent [ 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Stimulus-Responsive Shrinkage in Electrospun Membranes: Fundamentals and Control

Fang

Wang

et al. 2021

Micromachines

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Shrinkage is observed in many electrospun membranes. The stretched conformation of the macromolecular chains has been proposed as the possible cause. However, so far, our understanding of the fundamentals is still qualitative and cannot provide much help in the shrinkage control. In this paper, based on the crimped fibers after stimulus-induced shrinkage, a clear evidence of buckling, the gradient pre-strain field in the cross-section of the electrospun fibers, which is the result of a gradient solidification field and a tensile force in the fibers during electrospinning, is identified as the underlying mechanism for the stimulus-induced shrinkage. Subsequently, two buckling conditions are derived. Subsequently, a series of experiments are carried out to reveal the influence of four typical processing parameters (namely, the applied voltage, solution concentration, distance between electrodes, and rotation speed of collector), which are highly relevant to the formation of the gradient pre-strain field. It is concluded that there are some different ways to achieve the required shrinkage ratios in two in-plane directions (i.e., the rotational and transverse directions of the roller collector). Some of the combinations of these parameters are more effective at achieving high uniformity than others. Hence, it is possible to optimize the processing parameters to produce high-quality membranes with well-controlled shrinkage in both in-plane directions.

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Section: Introductionmentioning

confidence: 99%

Stimulus-Responsive Shrinkage in Electrospun Membranes: Fundamentals and Control

Fang

Wang

et al. 2021

Micromachines

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“…During cell alignment, it is well‐established that nuclei deforms in the same direction of cytoskeleton elongation, with both aligning parallel to ridge axis. [ 86,87 ] The resulting arrays of orientation angles were processed as radial plots for both nanopatterned and non‐patterned conditions (Figure 6E). Cells alignment exhibited high directional fidelity in nanopatterned oxLAM‐Gelatin hydrogels, following the nanoridge 45 °C angle uniformly, while no predominant orientation can be observed in non‐patterned hydrogels.…”

Section: Resultsmentioning

confidence: 99%

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Lavrador

Gaspar

Mano

2020

Adv Healthcare Materials

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Native human tissues are supported by a viscoelastic extracellular matrix (ECM) that can adapt its intricate network to dynamic mechanical stimuli. To recapitulate the unique ECM biofunctionality, hydrogel design is shifting from typical covalent crosslinks toward covalently adaptable networks. To pursue such properties, herein hybrid polysaccharide-polypeptide networks are designed based on dynamic covalent assembly inspired by natural ECM crosslinking processes. This is achieved through the synthesis of an amine-reactive oxidized-laminarin biopolymer that can readily crosslink with gelatin (oxLAM-Gelatin) and simultaneously allow cell encapsulation. Interestingly, the rational design of oxLAM-Gelatin hydrogels with varying aldehyde-to-amine ratios enables a refined control over crosslinking kinetics, viscoelastic properties, and degradability profile. The mechanochemical features of these hydrogels post-crosslinking offer an alternative route for imprinting any intended nano-or microtopography in ECM-mimetic matrices bearing inherent cell-adhesive motifs. Different patterns are easily paved in oxLAM-Gelatin under physiological conditions and complex topographical configurations are retained along time. Human adipose-derived mesenchymal stem cells contacting mechanically sculpted oxLAM-Gelatin hydrogels sense the underlying surface nanotopography and align parallel to the anisotropic nanoridge/nanogroove intercalating array. These findings demonstrate that covalently adaptable features in ECM-mimetic networks can be leveraged to combine surface topography and cell-adhesive motifs as they appear in natural matrices.

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“…Double-headed arrow, blood flow direction. Reprinted from Wang et al ( 14 ), with permission from IOP Publishing Ltd.…”

Section: Ecm Composition and Structure In The Vascular Wallmentioning

confidence: 99%

Stem Cell Based Approaches to Modulate the Matrix Milieu in Vascular Disorders

Sajeesh

Dahal

Bastola

et al. 2022

Front. Cardiovasc. Med.

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The extracellular matrix (ECM) represents a complex and dynamic framework for cells, characterized by tissue-specific biophysical, mechanical, and biochemical properties. ECM components in vascular tissues provide structural support to vascular cells and modulate their function through interaction with specific cell-surface receptors. ECM–cell interactions, together with neurotransmitters, cytokines, hormones and mechanical forces imposed by blood flow, modulate the structural organization of the vascular wall. Changes in the ECM microenvironment, as in post-injury degradation or remodeling, lead to both altered tissue function and exacerbation of vascular pathologies. Regeneration and repair of the ECM are thus critical toward reinstating vascular homeostasis. The self-renewal and transdifferentiating potential of stem cells (SCs) into other cell lineages represents a potentially useful approach in regenerative medicine, and SC-based approaches hold great promise in the development of novel therapeutics toward ECM repair. Certain adult SCs, including mesenchymal stem cells (MSCs), possess a broader plasticity and differentiation potential, and thus represent a viable option for SC-based therapeutics. However, there are significant challenges to SC therapies including, but not limited to cell processing and scaleup, quality control, phenotypic integrity in a disease milieu in vivo, and inefficient delivery to the site of tissue injury. SC-derived or -inspired strategies as a putative surrogate for conventional cell therapy are thus gaining momentum. In this article, we review current knowledge on the patho-mechanistic roles of ECM components in common vascular disorders and the prospects of developing adult SC based/inspired therapies to modulate the vascular tissue environment and reinstate vessel homeostasis in these disorders.

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Geometric anisotropy on biomaterials surface for vascular scaffold design: engineering and biological advances

Cited by 11 publications

References 94 publications

Stimulus-Responsive Shrinkage in Electrospun Membranes: Fundamentals and Control

Stimulus-Responsive Shrinkage in Electrospun Membranes: Fundamentals and Control

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Stem Cell Based Approaches to Modulate the Matrix Milieu in Vascular Disorders

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