Geoinformation

Konecny, G.

doi:10.1201/b12636

Cited by 18 publications

(2 citation statements)

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“…Response rates and stable disease rates were similar across the biomarker-defined populations as defined by t BRCA mutation and HRD status. Single-agent PARP inhibitors have demonstrated an ORR of approximately 25% to 30% in patients with platinum-resistant ovarian carcinoma and a BRCA mutation, but limited activity has been observed in patients with BRCA mutations and platinum-refractory disease (0%-14%) . The efficacy of PARP inhibitor monotherapy is even lower for patients who lack a BRCA mutation and have platinum-resistant (ORR, approximately 5%) or platinum-refractory (ORR, 0%) ovarian carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma

et al. 2019

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IMPORTANCE Patients with recurrent ovarian carcinoma frequently develop resistance to platinum-based chemotherapy, at which time treatment options become limited. OBJECTIVE To evaluate the poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor niraparib combined with pembrolizumab in patients with recurrent ovarian carcinoma. DESIGN, SETTING, AND PARTICIPANTS The TOPACIO/KEYNOTE-162 (Niraparib in Combination With Pembrolizumab in Patients With Triple-Negative Breast Cancer or Ovarian Cancer) trial, an open-label, single-arm phases 1 and 2 study enrolled women with advanced or metastatic triple-negative breast cancer (TNBC) or recurrent ovarian carcinoma, irrespective of BRCA mutation status. Median follow-up was 12.4 months (range, 1.2 to Ն23.0 months). Data were collected from

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Section: Discussionmentioning

confidence: 99%

Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma

et al. 2019

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“…Choosing the appropriate geographic location is critical for the long-term survival of the colonies underwater. Geoinformatics is the science which develops and uses information science infrastructure to address the problems of geography, cartography, geosciences and other related academic branches (Konecny, 2002). In ocean colonisation, geoinformatics is used in the 3D visualization of the seabed models.…”

Section: Geoinformaticsmentioning

confidence: 99%

Integrating Biomimicry and Geoinformatics: A Designerly Approach to Underwater Colonization

Varinlioğlu

Pasin

2018

International Journal of Environment and Geoinformatics

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Underwater space has been the subject of various scientific fields. In the field of architectural design, projects are generally limited to the areas of construction techniques for underwater as a civil engineering problem; underwater tourism; and underwater research. A much less researched area is ocean colonisation-permanent human settlement of oceans-and its architecture. This paper focuses on a case study of a workshop entitled "Mission Aquarius", as part of the architectural design studio. It treats oceanography in the context of extreme environments, and explores the use of biomimicry as a design approach, and the use of geoinformatics as site selection method. We encouraged students to explore various stages of scientific knowledge at the design level, and to employ various CAD/CAM tools. It is important to emphasize that the curriculum is a studio-based architectural design education with limited access to scientific data. It is aimed to integrate geoinformatics and biomimicry into the design studio, and to allow students to explore new contexts for design.

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