Geographically Distinct Expression Profile of Host Defense Peptides in the Skin  of the Chinese Odorous Frog,Odorrana margaretae

Ling, Guiying; LI, Li; Gao, Jiuxiang; Yu, Haining; Wang, Yipeng; Zhou, Jiang

doi:10.3724/sp.j.1245.2013.000288

Cited by 1 publication

(1 citation statement)

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“…However, it has a slighter DPPH radical scavenging ability with the eradication rate of 10.36% at the concentration of 80 μg/mL. 193 The identification of an AOP antioxidin-RL (AMRLTYNRPCIYAT) isolated from the skin secretions of frog Odorrana livida supports the idea that AOPs system is like to be widespread exist in the skin of amphibians. More than 75% of the ABTS + could be reduced after 5s by the treatment of antioxidin-RL at the concentration of 3 μM.…”

Section: Aops From Amphibiansmentioning

confidence: 72%

Antioxidant peptides, the guardian of life from oxidative stress

Zhu,

Wang,

Jia

et al. 2023

Medicinal Research Reviews

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Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic organisms. Under normal conditions, ROS production and elimination are in a relatively balanced state. However, under internal or external environmental stress, such as high glucose levels or UV radiation, ROS production can increase significantly, leading to oxidative stress. Excess ROS production not only damages biomolecules but is also closely associated with the pathogenesis of many diseases, such as skin photoaging, diabetes, and cancer. Antioxidant peptides (AOPs) are naturally occurring or artificially designed peptides that can reduce the levels of ROS and other pro‐oxidants, thus showing great potential in the treatment of oxidative stress‐related diseases. In this review, we discussed ROS production and its role in inducing oxidative stress‐related diseases in humans. Additionally, we discussed the sources, mechanism of action, and evaluation methods of AOPs and provided directions for future studies on AOPs.

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Section: Aops From Amphibiansmentioning

confidence: 72%