Geographical patterns of childhood cancer incidence in Europe, 1988–1997. Report from the Automated Childhood Cancer Information System project

Stiller, Charles; Marcos‐Gragera, Rafael; Ardanaz, E.; Pannelli, F; Marqués, Enrique Almar; Martinez, Andrew B.; Steliarova‐Foucher, Eva

doi:10.1016/j.ejca.2006.05.017

Cited by 66 publications

(33 citation statements)

References 4 publications

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“…First, it should be noted that the BI had the lowest incidence rates in Europe for all childhood cancers combined. The age-standardised rate was 131.1 per million compared with 138.5 per million for Europe as a whole with the highest rate of 160.1 per million in the North (Stiller et al, 2006a). The deficit was found among boys and girls at all ages throughout childhood.…”

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confidence: 88%

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What can we learn from geographical comparisons of childhood cancer survival?

Pritchard‐Jones

Stiller

2007

Br J Cancer

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With improvements in treatment for childhood cancer, comparisons of survival rates between countries have become important to inform future health policies and treatment strategies. Population-based cancer registry data are viewed as the gold standard for such comparisons, but even these have potential confounding factors. Here, we review the interpretation of recent geographical comparisons of childhood cancer survival from the viewpoint of the British Isles, a region with a 45-year record of national population-based cancer registration and a national childhood cancer clinical trials organisation in place for nearly 30 years. Using national data on referral patterns to tertiary paediatric oncology centres, we explore some of the reasons for lower survival rates in the past for some tumour groups and anticipate continued improvement in the next decade. Participation in international clinical trials coincided with rapid gains in survival for hepatoblastoma. This exemplifies the potential benefits of international collaborative clinical research, particularly for rare subgroups.

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confidence: 88%

“…The deficit was found among boys and girls at all ages throughout childhood. It was most marked in the first year of life, with more than half of the difference from the European average being accounted for by the relatively low incidence of neuroblastoma among infants (Stiller et al, 2006a). Incidence rates may influence survival in several ways.…”

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confidence: 99%

What can we learn from geographical comparisons of childhood cancer survival?

Pritchard‐Jones

Stiller

2007

Br J Cancer

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“…The most common tumours (age-adjusted rates per million for children aged 0–14) are leukaemia (Spain 47.0, Europe 44.0), central nervous system tumours (CNST) (Spain 33.2, Europe 29.9) and lymphoma (Spain 19.4, Europe 15.2) (Peris-Bonet et al, 2010; Stiller et al, 2006). The causes of PC are largely unknown, although in recent years an increase in incidence rates has been detected (Kaatsch, 2010; Ward et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Childhood cancer in small geographical areas and proximity to air-polluting industries

Ortega-García

Hernández

Cárceles-Álvarez

et al. 2017

Environmental Research

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Aim Pediatric cancer has been associated with exposure to certain environmental carcinogens. The purpose of this work is to analyse the relationship between environmental pollution and pediatric cancer risk. Method We analysed all incidences of pediatric cancer (< 15) diagnosed in a Spanish region during the period 1998–2015. The place of residence of each patient and the exact geographical coordinates of main industrial facilities was codified in order to analyse the spatial distribution of cases of cancer in relation to industrial areas. Focal tests and focused Scan methodology were used for the identification of high-incidence-rate spatial clusters around the main industrial pollution foci. Results The crude rate for the period was 148.0 cases per 1,000,0000 children. The incidence of pediatric cancer increased significantly along the period of study. With respect to spatial distribution, results showed significant high incidence around some industrial pollution foci group and the Scan methodology identify spatial clustering. We observe a global major incidence of non Hodgkin lymphomas (NHL) considering all foci, and high incidence of Sympathetic Nervous System Tumour (SNST) around Energy and Electric and organic and inorganic chemical industries foci group. In the analysis foci to foci, the focused Scan test identifies several significant spatial clusters. Particularly, three significant clusters were identified: the first of SNST was around energy-generating chemical industries (2 cases versus the expected 0.26), another of NHL was around residue-valorisation plants (5 cases versus the expected 0.91) and finally one cluster of Hodgkin lymphoma around building materials (3 cases versus the expected 2.2) Conclusion Results suggest a possible association between proximity to certain industries and pediatric cancer risk. More evidences are necessary before establishing the relationship between industrial pollution and pediatric cancer incidence.

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“…Kanser çocukluk çağında ender görülen bir hastalık olup, 0-14 yaş grubunda yılda yaklaşık her 100 bin çocuktan 10-15'i kanser tanısı almaktadır (1,2) . Down sendromu, nörofibromatozis, ailesel polipozis, Li-Fraumeni sendromu gibi ailesel/genetik hastalık-larda, immün yetmezliklerde, kanser tedavisi görmüş veya organ nakli yapılmış hastalarda kanser riski artar (1) .…”

Section: Introductionunclassified

Signs and Symptoms Accompaying Childhood Cancers

Vural¹,

Karaman²

2015

Cocuk Dergisi

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Geographical patterns of childhood cancer incidence in Europe, 1988–1997. Report from the Automated Childhood Cancer Information System project

Cited by 66 publications

References 4 publications

What can we learn from geographical comparisons of childhood cancer survival?

What can we learn from geographical comparisons of childhood cancer survival?

Childhood cancer in small geographical areas and proximity to air-polluting industries

Signs and Symptoms Accompaying Childhood Cancers

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