Geographical, ethnic, and genetic differences in pancreatic cancer predisposition

Liew, Sherilyn Zi Hui; Ng, K.; Ishak, Nur Diana Binte; Lee, Suat Ying; Zhang, Zewen; Chiang, Jianbang; Ngeow, Joanne

doi:10.21037/cco-23-8

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rising frequency of pancreatic adenocarcinoma in many high-income countries is linked to the changes in the prevalence of underlying risk factors, including the rising frequency of obesity, diabetes, and unhealthy dietary habits [36][37][38]. It is known that pancreatic adenocarcinoma is more common in males than females across various regions [1,39]. There is no difference in survival rates in pancreatic cancer by sex or geographical location [40].…”

Section: Discussionmentioning

confidence: 99%

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Ilic,

Ilic

2024

Cancers

View full text Add to dashboard Cite

(1) Background: This study aimed to assess the global burden of pancreatic cancer attributable to a high BMI in 1990–2019. (2) Methods: An ecological study was carried out. Data about deaths and Disability-Adjusted Life Years (DALYs) for pancreatic cancer were extracted from the Global Burden of Disease (GBD) study. The age-standardized rates (ASRs, per 100,000) were presented. In order to determine trends of pancreatic cancer burden, joinpoint regression analysis was used to calculate the average annual percent change (AAPC). (3) Results: The highest ASRs of DALYs of pancreatic cancer were found in the United Arab Emirates (47.5 per 100.000), followed by countries with about 25.0 per 100,000 (such as Hungary, Czechia, and Montenegro). From 1990 to 2019, the ASRs of deaths and DALYs of pancreatic cancer attributable to a high BMI significantly increased (p < 0.001) for both sexes in all ages, and across all SDI quintiles and all GBD regions. The highest fraction of DALYs attributable to a high BMI was found in the United States of America and China (equally about 15.0%), followed by the Russian Federation, India, Germany, and Brazil (about 5.0%, equally). (4) Conclusions: Further analytical epidemiological studies are necessary to elucidate the relationship between pancreatic cancer and a high BMI.

show abstract

Section: Discussionmentioning

confidence: 99%

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Ilic,

Ilic

2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Approximately 10% of all pancreatic cancer cases are purportedly linked to Familial Pancreatic Cancer (FPC), denoting families exhibiting a notably high incidence of the disease. FPC is recognized as a genetically heterogeneous condition, driven by inherited pathogenic variants within specific genes [2].…”

Section: Introductionmentioning

confidence: 99%

Uncovering Pathogenic Variants in Cancer Susceptibility Genes through Genetic Testing for Pancreatic Cancer Patients

Potska,

Katseli,

Agiannitopoulos

et al. 2024

Preprint

View full text Add to dashboard Cite

Pancreatic cancer stands out as one of the most lethal forms of malignancies, representing 2% of all cancer cases and contributing to 5% of cancer-related fatalities. Therefore, early detection of pancreatic cancer is crucial for enhancing treatment outcomes. Various hereditary cancer syndromes have been linked to an elevated risk of developing pancreatic cancer, suggesting potential benefits from surveillance strategies for individuals at risk. Presently, precision medicine employs PARP inhibitor therapy for pancreatic cancer patients carrying germline variants in Homologous Recombination Repair (HRR) genes. Our objective was to ascertain the occurrence of germline pathogenic/likely pathogenic variants in genes predisposing to cancer among pancreatic cancer patients. Methodologically, we analyzed 184 pancreatic cancer patients referred to our laboratory for genetic examination. Utilizing a Next-Generation Sequencing (NGS) approach, we scrutinized 52 genes implicated in hereditary cancer predisposition. Our findings revealed that 21% of the patients analyzed harbored germline pathogenic/likely pathogenic variants. Within this subset, 48% exhibited positive results in pancreatic cancer susceptibility genes, namely ATM (17%), BRCA1 (12%), BRCA2 (7%), CDKN2A (7%), and PALB2. Significantly, 64.3% of the pathogenic variants were associated with genes involved in the HRR pathway (ATM, BRCA1, BRCA2, BRIP1, CHEK2, FANCL, MRE11, PALB2, RAD50, RAD51B and RAD51C). In conclusion, our study underscores the significance of multigene genetic testing for pancreatic cancer patients, with 21% of individuals yielding findings linked to pancreatic or other cancer predisposition. Moreover, patients carried pathogenic/likely pathogenic variants in HRR genes, potentially benefiting from targeted therapies such as PARP inhibitors or platinum-based treatments.

show abstract

Exploring Disparities in Pancreatic Ductal Adenocarcinoma Outcomes among Asian and Pacific Islander Subgroups

Wu,

McLeod,

Song

et al. 2024

Cancer Research Communications

View full text Add to dashboard Cite

Pancreatic adenocarcinoma (PDAC) is a challenging malignancy with known disparities in outcomes across ethnicities. Studies specifically investigating PDAC in Asian populations are sparse, overlooking the rich diversity within this group. This research seeks to fill that gap by examining survival differences across the broad spectrum of Asian ethnicities, acknowledging the complexity and varied experiences within these communities. Utilizing the National Cancer Database from 2004 to 2019, we categorized patients into East Asian, Southeast Asian, South Asian, and Pacific Islander groups. Non-Asian or Pacific Islanders were excluded. Overall Survival was analyzed using a Cox hazards model. The study consisted of 13,254 patients. Most patients were East Asian (59.4%, n=7,866). Southeast Asians exhibited the poorest survival in unadjusted analysis (HR: 1.32, 95%CI: 1.23-1.42, p<0.001) compared to South Asians who had the best. Multivariable analysis revealed significantly worse survival for East Asians and Pacific Islanders relative to South Asians, while Southeast Asians' results were not significantly different. Asian subgroup differences notably affect PDAC outcomes. Research on genetic and cultural aspects, especially in Southeast Asians, and tackling health disparities, is crucial for enhancing survival in this diverse disease

show abstract

Geographical, ethnic, and genetic differences in pancreatic cancer predisposition

Cited by 4 publications

References 0 publications

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Global Burden of Pancreatic Cancer Attributable to High Body-Mass Index in 204 Countries and Territories, 1990–2019

Uncovering Pathogenic Variants in Cancer Susceptibility Genes through Genetic Testing for Pancreatic Cancer Patients

Exploring Disparities in Pancreatic Ductal Adenocarcinoma Outcomes among Asian and Pacific Islander Subgroups

Contact Info

Product

Resources

About