Geographical distribution of Leishmania species in Colombia, 1985-2017

Abstract

Introduction: Knowledge of the geographical distribution of Leishmania species allows guiding the sampling to little-studied areas and implementing strategies to define risk zones and priority areas for control.Objective: Given that there is no publication that collects this information, the search, review, and compilation of the available scientific literature that has identified species in Colombia is presented in this paper.Materials and methods: A bibliographic search was performed in PubMed, Web of Knowledge, Google Scholar, SciELO and LILACS with the terms “(Leishmania OR Leishmaniasis) AND species AND Colombia”, without restrictions on publication year, language or infected organism; records of national scientific events and repositories of theses from Colombian universities were also included.Results: Eighty-six scientific documents published between 1985 and 2017 were found in which the species of Leishmania and their geographical origin were indicated. The species reported, in descending order of frequency, were: Leishmania (Viannia) panamensis, L. (V.) braziliensis, L. (V.) guyanensis, L. (Leishmania) infantum, L. (L.) amazonensis, L. (L.) mexicana, L. (V.) colombiensis, L. (V.) lainsoni and L. (V.) equatorensis; the last three were found with the same frequency. Leishmania species were reported from 29 departments. Conclusion: Information on the distribution of Leishmania species in Colombia is limited; therefore, it is necessary to gather existing data and propose studies that consolidate the distribution maps of Leishmania species in Colombia. This would allow the detection of areas where species have not been identified as well as the comparison of existing parasite and vector distributions.

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I

“…L. braziliensis is the causative agent of human CL and MCL in various countries of the American continent, including Colombia, Brazil, Nicaragua, and Ecuador, among others [ 49 , 54 , 55 ]. Thus, to validate the hybrid model constructed for Lb PTR1 and to evaluate the protein–ligand stabilities of the structures 135 , 302 , and 302a , molecular dynamics (MD) studies were performed using DHB and PMA as reference ligands.…”

An Updated Geographical Distribution of Leishmania Species Involved in Human Leishmaniasis in Colombia

“…L. mexicana was reported in Antioquia in 2006 in a patient [41]. Notably, L. mexicana has been reported as causative agents of CL, but also as responsible of one case of diffuse CL [42] and other case of transfusion-transmitted VL in a immunocompromised patient [43]. L. guyanensis is reported in 12 departments in Colombia, especially those located in the Andean and Amazonian region but also in the departments of Cordoba and Sucre in the Caribbean region (Table 2).…”

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

“…Regarding Leishmania species, most of the studies were conducted on L. panamensis ( Figure 4B). This fact can be considered reasonable due to the fact that L. panamensis is the etiological agent most frequently reported in Colombia [3,6]. However, recent studies reported that L. braziliensis and L. guyanensis have relevant epidemiological reports and wide spatial distribution in Colombia [68,69].…”

“…In Colombia, the incidence rate of this disease was 26.2 cases per 100,000 population, with 98.6% of the cases related to CL [2]. Such an incidence was due to the presence of several parasites species, including L. venezuelensis, L. equatorensis, L. lainsoni, L. colombiensis, L. mexicana, L. amazonensis, L. infantum, L. guyanensis, L. braziliensis and L. panamensis [3][4][5][6], with the last three Leishmania species being the most representative etiological agents [4,6].…”