Geographical distribution and pathogenesis of ticks and tick-borne viral diseases

Shah, Taif; Li, Qian; Wang, Binghui; Baloch, Zulqarnain; Xia, Xueshan

doi:10.3389/fmicb.2023.1185829

Cited by 8 publications

(4 citation statements)

References 177 publications

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“…The M segment of the virus encodes a polyprotein precursor that is cleaved into the glycoproteins Gn and Gc. Gc is a fusion protein enabling virus entry into host cells [ 5 ].…”

Section: Virus Structurementioning

confidence: 99%

Heartland Virus Disease—An Underreported Emerging Infection

Dembek,

Mothershead,

Cirimotich

et al. 2024

Microorganisms

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First recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick (Amblyomma americanum) and potentially other tick species. Heartland symptoms include a fever <100.4 °F, lethargy, fatigue, headaches, myalgia, a loss of appetite, nausea, diarrhea, weight loss, arthralgia, leukopenia and thrombocytopenia. We reviewed the existing peer-reviewed literature for HRTV and Heartland to more completely characterize this rarely reported, recently discovered illness. The absence of ongoing serosurveys and targeted clinical and tickborne virus investigations specific to HRTV presence and Heartland likely contributes to infection underestimation. While HRTV transmission occurs in southern and midwestern states, the true range of this infection is likely larger than now understood. The disease’s proliferation benefits from an expanded tick range due to rising climate temperatures favoring habitat expansion. We recommend HRTV disease be considered in the differential diagnosis for patients with a reported exposure to ticks in areas where HRTV has been previously identified. HRTV testing should be considered early for those matching the Heartland disease profile and nonresponsive to initial broad-spectrum antimicrobial treatment. Despite aggressive supportive therapy, patients deteriorating to sepsis early in the course of the disease have a very grim prognosis.

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“…The M segment of the virus encodes a polyprotein precursor that is cleaved into the glycoproteins Gn and Gc. Gc is a fusion protein enabling virus entry into host cells [ 5 ].…”

Section: Virus Structurementioning

confidence: 99%

Heartland Virus Disease—An Underreported Emerging Infection

Dembek,

Mothershead,

Cirimotich

et al. 2024

Microorganisms

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“… Geographical distribution of primary tick vectors and tick-borne pathogens. Green numbers represent the tick vectors, violet numbers denote the tick-borne bacteria and protozoa, and orange numbers indicate tick-borne viruses [ 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. …”

Section: Figurementioning

confidence: 99%

Human Tick-Borne Diseases and Advances in Anti-Tick Vaccine Approaches: A Comprehensive Review

Nepveu-Traversy,

Fausther-Bovendo,

Babuadze

2024

Vaccines

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This comprehensive review explores the field of anti-tick vaccines, addressing their significance in combating tick-borne diseases of public health concern. The main objectives are to provide a brief epidemiology of diseases affecting humans and a thorough understanding of tick biology, traditional tick control methods, the development and mechanisms of anti-tick vaccines, their efficacy in field applications, associated challenges, and future prospects. Tick-borne diseases (TBDs) pose a significant and escalating threat to global health and the livestock industries due to the widespread distribution of ticks and the multitude of pathogens they transmit. Traditional tick control methods, such as acaricides and repellents, have limitations, including environmental concerns and the emergence of tick resistance. Anti-tick vaccines offer a promising alternative by targeting specific tick proteins crucial for feeding and pathogen transmission. Developing vaccines with antigens based on these essential proteins is likely to disrupt these processes. Indeed, anti-tick vaccines have shown efficacy in laboratory and field trials successfully implemented in livestock, reducing the prevalence of TBDs. However, some challenges still remain, including vaccine efficacy on different hosts, polymorphisms in ticks of the same species, and the economic considerations of adopting large-scale vaccine strategies. Emerging technologies and approaches hold promise for improving anti-tick vaccine development and expanding their impact on public health and agriculture.

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“…About 25% of these are associated with diseases, and notably, all are zoonotic [ 21 ]. Recently, Shah et al [ 22 ] provided a comprehensive review on the subject of TBVs and TBVDs, covering crucial aspects like their epidemiology, pathogenesis, and clinical manifestations. Building on this groundwork, this review will distill the essential aspects of the most significant TBVs and TBVDs in relation to bats, emphasizing their incidence and the associated risks to human populations in the Americas and the Caribbean region.…”

Section: Ticks-borne Diseases: Transmission Of Viruses From Ticks To ...mentioning

confidence: 99%

Tick-borne viruses and their risk to public health in the Caribbean: Spotlight on bats as reservoirs in Cuba

Antúnez,

Marín Montesinos,

Corduneanu

et al. 2024

Heliyon

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Geographical distribution and pathogenesis of ticks and tick-borne viral diseases

Cited by 8 publications

References 177 publications

Heartland Virus Disease—An Underreported Emerging Infection

Heartland Virus Disease—An Underreported Emerging Infection

Human Tick-Borne Diseases and Advances in Anti-Tick Vaccine Approaches: A Comprehensive Review

Tick-borne viruses and their risk to public health in the Caribbean: Spotlight on bats as reservoirs in Cuba

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