Geographical and genetic diversity of the human hepatitis B virus

Kurbanov, Fuat; Tanaka, Yasuhito; Mizokami, Masashi

doi:10.1111/j.1872-034x.2009.00601.x

Cited by 193 publications

(189 citation statements)

References 274 publications

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“…This is not observed in the present study; nevertheless, the small sample size must be taken into consideration. Concerning HBV genotypes, genotype D was the most frequent, followed by genotypes A and E. This observation is in agreement with the known geographic distribution pattern for this virus, since genotype D is more common in Western Europe [18].…”

Section: Molecular Diagnosis Of Hepatitis B and C Virussupporting

confidence: 76%

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

Silva

Moniz

Pereirinha

et al. 2016

J Infect Dev Ctries

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Introduction: We performed a descriptive analysis of molecular diagnosis of infectious agents in the São Miguel Island population, in order to address questions like what is the frequency of clinical requests, is it observable seasonality of pathogens, and what is the positive rate for the clinical diagnosis. Methodology: This was a retrospective and descriptive study based on 878 individuals suspected of harboring infectious diseases during two consecutive years, 2012-2013. More than 25 different pathogens were investigated by polymerase chain reaction (PCR)-based methods. The individuals were stratified into gender, occupation, and age groups. Results: The pathogen with more clinical requests was hepatitis C virus, investigated in 225 individuals (30.0%), followed by Leptospira spp., in 187 (24.9%). Overall, data demonstrated a gender distribution bias, where 72.9% of cases were males. The age group of 25 to 44 years was the class with more clinical requests. Regarding occupation, a predominance of construction workers (12.0%) was observed, followed by retired workers (11.0%). Patient distribution per year showed a higher number of patients in the fall months. Diagnoses of leptospirosis and respiratory virus infections presented seasonality. Conclusions: The present study provides a valid contribution to the knowledge of the epidemiology of infectious diseases in the São Miguel Island (Azores, Portugal) population.

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Section: Molecular Diagnosis Of Hepatitis B and C Virussupporting

confidence: 76%

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

Silva

Moniz

Pereirinha

et al. 2016

J Infect Dev Ctries

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“…Human migrations and miscegenation defined the pattern of geographical distribution observed today. [8][9][10] Genetic diversity, besides being associated with the clinical severity, treatment failure, and factors affecting vaccine response, 11 may also contribute as tools for characterizing transmission patterns. [12][13][14] Seroepidemiological studies, carried out in the municipality of Lá brea after the introduction of the hepatitis B vaccine in 1989, revealed a pattern of low and moderate endemicity of HBV infection with an anti-HBc total prevalence of 27.9% among those born in the city of Lá brea to a high prevalence among individuals from the rural zone (67.9%).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAgpositive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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“…Genotip A, Sahraaltı Afrika, Kuzey Avrupa ve Batı Avrupa; genotip B, Tayvan ve Vietnam; genotip C, Çin, Japonya ve Kore; genotip D, Hindistan, Avrupa, Afrika ve Akdeniz ülkeleri; genotip E, Batı Afrika; genotip F, Orta ve Güney Amerika; genotip G, Fransa, Almanya ve Amerika Birleşik Devletleri (ABD); genotip H, Orta Amerika; genotip I, Vietnam ve Laos; genotip J, Japonya'da saptanmaktadır (32)(33)(34)(35). Ülkemizde karşılaşılan genotiplerin tamamına yakını, genotip D'dir (36)(37)(38).…”

Section: Epidemiyolojiunclassified

Management of Chronic Hepatitis B Virus Infection: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases

Akhan¹,

Aynıoğlu²,

Çağatay³

et al. 2015

Klimik Dergisi

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ÖzetTürk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Derneği Viral Hepatit Çalışma Grubu, dünyada 400 milyonun üzerinde kişide bulunan kronik hepatit B virusu (HBV) infeksiyonunun yönetimi-ne ilişkin bir uzlaşı raporu hazırlamak üzere bir toplantı düzenle-miştir. Raporda konuyla ilgili literatür ve uluslararası kılavuzlar, hepatit B virusu (HBV) infeksiyonunun epidemiyolojisi ve doğal seyri, kronik hepatit B (KHB)'nin ülke ekonomisine maliyeti, akut hepatit B (AHB) ve KHB'de tanı, AHB'nin KHB akut alevlenmesinden ayırt edilmesi, KHB tedavisi, HBeAg-pozitif ve negatif hastalarda tedaviye yanıtın değerlendirilmesi ve uzun dönem sonuçları, nükleoz(t)id analoglarına karşı viral direnç ve direncin izlemi ve hepatit B'den korunma gibi bölümler halinde gözden geçirilmiş ve üzerinde uzlaşılan öneriler her bölümün sonunda sunulmuştur. Bu önerilerden seçilmiş birkaçı aşağıda sıralan-mıştır: [1] İlk basamak tedavisi olarak entekavir ya da tenofovir gibi dirence karşı genetik bariyeri yüksek çok güçlü ilaçların seçilmesi, uzun süreli tedavi hedeflerine ulaşmak için en uygun AbstractStudy Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases convened a meeting to develop a consensus report on management of chronic hepatitis B virus (HBV) infection, a global public health problem, affecting more than 400 million people worldwide. Relevant literature and international guidelines were reviewed, and recommendations agreed are presented at the end of each section such as epidemiology and natural history of HBV infection, economic burden of chronic hepatitis B (CHB), diagnosis of acute hepatitis B (AHB) and CHB, differentiation of AHB from acute exacerbation of CHB, treatment of CHB, evaluation of response to treatment and longterm outcomes in HBeAg-positive and negative patients, antiviral resistance and its follow-up, and prevention of HBV infection. Examples of some selected recommendations are as follows: [1] The selection of a highly potent drug such as entecavir or tenofovir with a high genetic barrier to resistance as a first line therapy provides the best approach of achieving the goals of long-term

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Geographical and genetic diversity of the human hepatitis B virus

Cited by 193 publications

References 274 publications

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Management of Chronic Hepatitis B Virus Infection: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases

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