Abstract:had > 2 opioid prescriptions, we identified beneficiaries with high-dose use (> 120 daily morphine milligram equivalents for ≥ 90 consecutive days) and multiple providers (≥ 4 prescribers and ≥ 4 pharmacies) each year; and concurrent benzodiazepine use (≥ 30 cumulative days) from 2013-2015 when Part D began coverage for benzodiazepines. We obtained adjusted annual rates of high-risk measures across 306 hospital referral regions (HRRs) using multivariable logistic regression and examined the association between… Show more
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