D iabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM) and is the leading cause of blindness in the United States [1]. The prevalence of DM has increased rapidly in the United States. In 2015, an estimated 30.3 million people or 9.4% of the US population had DM [2]. By the year 2050, it is expected that about 48.3 million adults will be affected by DM [3]. The burden of DR may increase as more people have DM. It is estimated that about 16.0 million adults aged ≥ 40 years are projected to have DR by 2050 [4]. DR prevalence and complications are higher among racial/ethnic minority populations, including African Americans, Hispanics, and American Indians [5]. North Carolina is one of the 15 southern states identified as being in the "diabetes belt" by the Centers for Disease Control and Prevention [6]. North Carolina has the 13th highest prevalence of DM in the United States. An estimated 750,000 (1 in 10) adults in North Carolina have been diagnosed with DM [7]. By 2025, the number of people with DM in North Carolina is projected to increase to almost 1.9 million, with an annual cost to the state of $17.9 billion (including both medical and non-medical costs) [8]. Racial and ethnic disparities in DM prevalence are also significant in North Carolina. In 2013, 11.0% of non-Hispanic white adults had DM compared to 15.4% of non-Hispanic black adults [9]. The early stages of DR are often asymptomatic. Thus, early detection and treatment is imperative to preventing vision loss. Population-based studies on DR trends in the United States [10-12] are very limited. Little data exists on DR status in North Carolina [13]. The target of Healthy People 2020 is to reduce DR to 30.8 per 1,000 in the population aged 18 years and older with DM [14]. The purpose of this study is to describe the trends of DR in adults with DM and to assess racial/ethnic disparities in DR in the past 15 years in North Carolina. An update on the current status of DR will provide useful information for both eye care professionals and other medical providers in their practice and inform public health officials in the design or modification of interventions and policies regarding DR and DM. Methods Data For this study, data from the Behavioral Risk Factor Surveillance System (BRFSS) was analyzed. The BRFSS is an annual state-based, random-digit-dialed telephone survey of the non-institutionalized, US civilian population aged 18 years and older. The BRFSS questionnaire consists of 3 sections: a core survey, optional modules, and stateadded questions [15]. BRFSS has been proven to provide valid national and state estimates of health and risk factors [16]. In the BRFSS Core Questionnaire, respondents