Geographic heterogeneity of cellular characteristics of acute myeloid leukemia: a comparative study of Australian and Japanese adult cases

Nakase, Kazunori; Bradstock, Kenneth F.; Sartor, Mary; Gottlieb, David; Byth, Karen; Kita, K; Shiku, Hiroshi; Kamada, Nanao

doi:10.1038/sj.leu.2401638

Cited by 50 publications

(56 citation statements)

References 33 publications

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“…The frequency of aberrant karyotypes in our study was 35.6%, which was lower than the reported values for patients from the United Kingdom (UK) (52.0%, age range 44-91 years) (Grimwade et al, 2001), Hong Kong (58.0%, age range 60-89 years) (So et al, 2011), Austria (58.1%, age range 55-86 years) (Nakase et al, 2000), Japan (49.0%, age range 55-91 years) (Nakase et al, 2000), and south China (50.7%, age range 50-89 years) (Cheng et al, 2010).…”

Section: Discussioncontrasting

confidence: 79%

“…Our results indicated an occurrence rate of 8.89% for t (8;21) (q22;q22), which was higher than the reported rates in the UK (2.16%) (Grimwade et al, 2001), Austria (1.16%) (Nakase et al, 2000), and Hong Kong (3.70%) (So et al, 2011), but comparable to those reported in Japan (9.50%) (Nakase et al, 2000), and south China (5.96%) (Cheng et al, 2010). Furthermore, the frequencies of -5/5q-and -7/7q-were 3.33% and 1.11%, respectively in our study, which were lower than the reported rates in the UK (12.6% and 12.6%) (Grimwade et al, 2001), but similar to those in south China (1.15% and 1.38%) (Cheng et al, 2010).…”

Section: Discussioncontrasting

confidence: 75%

“…The incidence rate of t (15;17) (q22;q21) was 10.0% in the present study, which was higher than the reported rates in the UK (4.04%) (Grimwade et al, 2001) and Hong Kong (2.96%) (So et al, 2011), but similar to those reported in Austria (11.6%) (Nakase et al, 2000), Japan (8.00%) (Nakase et al, 2000), and south China (9.18%) (Cheng et al, 2010). Our results indicated an occurrence rate of 8.89% for t (8;21) (q22;q22), which was higher than the reported rates in the UK (2.16%) (Grimwade et al, 2001), Austria (1.16%) (Nakase et al, 2000), and Hong Kong (3.70%) (So et al, 2011), but comparable to those reported in Japan (9.50%) (Nakase et al, 2000), and south China (5.96%) (Cheng et al, 2010).…”

Section: Discussionsupporting

confidence: 64%

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Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

Li²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objectives: The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. Methods: A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. Results: The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzed cases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those with complex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively. The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and 33.3%, respectively (χ 2 = 0.704, P = 0.703) based on risk stratification. Conclusion: Cytogenetics and genetic mutations alone may not be sufficient to evaluate the prognoses of elderly AML patients. The search for a novel model that would enable a more comprehensive evaluation of this population is therefore imperative.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussioncontrasting

confidence: 75%

Section: Discussionsupporting

confidence: 64%

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Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

Li²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In most reports CD34 positivity in non-APL AML has varied between 55.8 and 69.1% [13][14][15]. We have found that HLA-DR is the single best marker for distinguishing APL from other Fig.…”

Section: Leukemia Subtypesmentioning

confidence: 54%

Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Salem

El-Aziz

2011

Indian J Hematol Blood Transfus

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Acute leukemia (AL) displays characteristic patterns of antigen expression, which facilitate their identification and proper classification. The purpose of this study is to evaluate the diagnostic usefulness of commonly used immune-markers for immunophenotyping of AL and to define the best immune-markers to be used for proper diagnosis and classification of AL. Besides, to recognize the frequency of different AL subtypes and the antigen expression profile in our Egyptian patients. We retrospectively analyzed the immunophenotypic data of 164 de novo AL patients from our institution during 2009 and 2010. Among these patients, 68.9% were classified as acute myeloblastic leukemia (AML) while 31.1% classified as acute lymphoblastic leukemia (ALL). The commonest FAB subtype in AML group was AML-M4/5 (34.5%) which may differ from most published data. As regard ALL, there were 74.5% with B-ALL and 25.5% with T-ALL. It was found that combined use of HLADR and CD34 was much more helpful in distinguishing APL from non-APL AML than either of these antigens alone. It was found that cCD79a and CD19 were the most sensitive marker for B-ALL while cCD3, CD7 and CD5 were the most sensitive antigens for T-ALL. Our analysis of AL phenotypes proved that employed antibody panels are adequate for proper diagnosis and classification of AL. Flowcytometry was found to be especially useful in the identification of AML-M0 and differentiation of APL from non-APL AML. Immunophenotyping results and FAB classification of our AL patients were comparable to internationally published studies apart from predominance of AML-M4/5 and more frequent APL.

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“…However, most of these observations were from western populations and few systematical research based on large sample sizes from Asian populations was available. The presence of geographic heterogeneity of cytogenetic abnormalities in hematological malignancies has been described (Johansson et al, 1991;Nakase et al, 2000;Chen et al, 2005), so the aim of the present study was to investigate the prevalence, feature, and specific prognostic relevance of MK in Chinese AML patients from a single center in China.…”

Section: Introductionmentioning

confidence: 99%

Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

Yang

Sun²,

Yin³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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A monosomal karyotype (MK), defined as ≥2 autosomal monosomies or a single monosomy in the presence of additional structural abnormalities, was recently identified as an independent prognostic factor conveying an extremely poor prognosis in patients with acute myeloid leukemia (AML). In the present study, after excluding patients with t(15;17), t(8;21), inv(16) and normal karyotypes, 324 AML patients with cytogenetic abnormalities were the main subject of analysis. The incidences of MK were 13% in patients aged 15 to 60 years and 18% in those between 15 and 88 years old. MK was much more prevalent among elderly patients (p < 0.001) and was significantly associated with the presence of -7, -5, del(5q), abn12p, abn17p, -18 or 18q-, -20 or 20q-and CK (for all p < 0.001 except for abn12p p=0.009), and +8 or +8q was less frequent in MK+ AML(p=0.007). No correlation was noted between monosomal karyotype and FAB subtype (p > 0.05); MK remained significantly associated with worse overall survival among patients with complex karyotype (p= 0.032); A single autosomal monosomy contributed an additional negative effect in OS of patients with structural cytogenetic abnormalities (P=0.008). This report presents the prevalence, feature and prognostic impact of MK among a large series of Chinese AML patients from a single center for the first time.

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Geographic heterogeneity of cellular characteristics of acute myeloid leukemia: a comparative study of Australian and Japanese adult cases

Cited by 50 publications

References 33 publications

Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

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