Geographic/ethnic variability of chromosomal and molecular abnormalities in leukemia

Braekeleer, Marc De; Braekeleer, Étienne De; Douet‐Guilbert, Nathalie

doi:10.1586/14737140.2015.1068123

Cited by 7 publications

(4 citation statements)

References 131 publications

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“…Although a geographic/ethnic uneven distribution cannot be ruled out, it is likely that differences in diagnosis (PLL included or not), referral, access to care and healthcare systems may have affected the frequency. Even for those investigated at diagnosis, we cannot exclude that socioeconomic status or access to healthcare may have delayed the time at which diagnosis was made, with the consequence that patients in some series were at a more advanced stage (20,21). A limited number of studies attempted to identify the partner genes.…”

Section: Frequency and Distribution Of Ig Translocationsmentioning

confidence: 99%

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Braekeleer

Tous

Guéganic

et al. 2016

Molecular and Clinical Oncology

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Abstract. Chronic lymphocytic leukemia (CLL) represents the most common hematological malignancy in Western countries, with a highly heterogeneous clinical course and prognosis. Translocations involving the immunoglobulin (IG) genes are regularly identified. From 2000 to 2014, we identified an IG gene translocation in 18 of the 396 patients investigated at diagnosis (4.6%) and in 17 of the 275 analyzed during follow-up (6.2%). A total of 4 patients in whom the IG translocation was identified at follow-up did not carry the translocation at diagnosis. The IG heavy locus (IGH) was involved in 27 translocations (77.1%), the IG κ locus (IGK) in 1 (2.9%) and the IG λ locus (IGL) in 7 (20.0%). The chromosome band partners of the IG translocations were 18q21 in 16 cases (45.7%), 11q13 and 19q13 in 4 cases each (11.4% each), 8q24 in 3 cases (8.6%), 7q21 in 2 cases (5.7%), whereas 6 other bands were involved once (2.9% each). At present, 35 partner chromosomal bands have been described, but the partner gene has solely been identified in 10 translocations. CLL associated with IG gene translocations is characterized by atypical cell morphology, including plasmacytoid characteristics, and the propensity of being enriched in prolymphocytes. The IG heavy chain variable region (IGHV) mutational status varies between translocations, those with unmutated IGHV presumably involving cells at an earlier stage of B-cell lineage. All the partner genes thus far identified are involved in the control of cell proliferation and/or apoptosis. The translocated partner gene becomes transcriptionally deregulated as a consequence of its transposition into the IG locus. With the exception of t(14;18)(q32;q21) and its variants, prognosis appears to be poor for the other translocations.Therefore, searching for translocations involving not only IGH, but also IGL and IGK, by banding and molecular cytogenetics is required. Furthermore, it is important to identify the partner gene to ensure the patients receive the optimal treatment.

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Section: Frequency and Distribution Of Ig Translocationsmentioning

confidence: 99%

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Braekeleer

Tous

Guéganic

et al. 2016

Molecular and Clinical Oncology

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“…In 1963 Jean Bernard, an icon in the world of hematology, presented the concept of "geographic hematology" and distinguished 2 major branches, i.e., the so called "ethnic hematology," which deals with differences between populations, and "environmental hematology," which deals with environmental factors such as food habits, infections, and hematological diseases [5]. It has been shown that Mexico is not the exception and diverse studies have reported differences in rates of distinct hematological diseases when compared to other countries or regions.…”

Section: Introductionmentioning

confidence: 99%

Geographic Hematology: Some Observations in Mexico

et al. 2018

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In 1963 Jean Bernard introduced the concept of “geographic hematology” and distinguished 2 branches, i.e., “ethnic hematology,” which deals with differences between populations, and “environmental hematology,” which considers factors such as food habits, infections, and others. Both of these branches have implications in the distribution of hematological diseases worldwide. In comparison with Caucasian populations, in Mexico a significantly higher prevalence of acute lymphoblastic, acute promyelocytic, and acute megakaryoblastic leukemias has been described. The rate of chronic myeloid leukemia seems to be as high as that reported in Caucasian populations, while other myeloproliferative neoplasias are significantly less frequent in Mexico. Significantly lower prevalences of hairy cell leukemia, chronic lymphocytic leukemia, multiple myeloma, and Waldenström’s macroglobulinemia have been reported from Mexico. Regrettably, the influence of drug companies interested in selling their new and expensive drugs has resulted in both overdiagnosis of some diseases and overidentification of the refractory forms of some of these conditions to justify the use of unnecessary drugs.

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“…Jean Bernard, an icon in the world's hematology, presented in 1963 the concept of "geographic hematology" distinguishing two major branches; the so-called "ethnic hematology" that dealt with differences between populations and a second branch about environmental factors such as food habits, infections, and its implication with the hematological diseases referred as "environmental hematology" 4,7 . Along this line, we have analyzed the salient features of several hematological diseases, making comparisons with the features of some conditions in other populations 4 : we have shown that two B-cell malignancies, both CLL and multiple myeloma, are less frequent and less aggressive in México than in Caucasian populations 4,8,9 .…”

Section: Discussionmentioning

confidence: 99%

Mantle cell lymphoma may have a different clinical course in Mexican Mestizos: Real-world data from a single center

Córdova-Ramírez

Sánchez-Valledor

Colón‐Otero

et al. 2021

RIC

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Background: The biology of some hematological diseases varies among different populations. No previous studies have evaluated the clinical behavior of mantle cell lymphoma (MCL) in México. Objective and Methods: This is a retrospective review of MCL cases seen in Mexico from January 2003 to June 2020. A total of 12 cases were identified. Results: There were nine males and three females; median age was 56 years. Eight patients had a high MCL international prognostic index score, one was intermediate, and three were low. Five patients had circulating malignant monoclonal cells. Initial treatment included rituximab, cyclophosphamide, daunorubicin, vincristine, and prednisone (R-CHOP) and CHOP. Subsequent treatment included hematopoietic stem cell transplantation in five patients; two were given maintenance therapy. Splenectomy was done in four patients. Median overall survival (OS) for all the patients has not been reached and exceeds 162 mos: OS at 162 mos was 56%. Achieving a complete remission (CR) after the first treatment was a significant prognostic factor, with a median OS exceeding 141 mos in patients achieving CR, and 16 mos among those not achieving CR (p = 0.0006). Conclusion: Some of MCL patients in Mexico have an indolent clinical course, particularly patients who achieve a CR to initial treatment and who undergo splenectomy. (REV INVEST CLIN. [AHEAD OF PRINT]

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Geographic/ethnic variability of chromosomal and molecular abnormalities in leukemia

Cited by 7 publications

References 131 publications

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Geographic Hematology: Some Observations in Mexico

Mantle cell lymphoma may have a different clinical course in Mexican Mestizos: Real-world data from a single center

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