Geographic Distribution and Incidence of Melioidosis, Panama1

Araúz, Ana Belén; Castillo, Katiana; Santiago, Erika; Quintero, Yarineth; Adames, Enrique; Castillo, B Paul; Rodríguez-French, A; Henostroza, German

doi:10.3201/eid2601.180870

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…15 articles, with a total of 29 patients were excluded due to insufficient clinical information (n = 12) [ 1 , 3 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ] or no report of microbiological diagnosis (n = 3) [ 21 , 22 , 23 ]. A total of 31 articles [ 5 , 10 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ] with 41 patients met the inclusion criteria of this systematic review. We did not exclude articles based on language, although only English-language articles were identified by our search strategy.…”

Section: Resultsmentioning

confidence: 99%

“…Whitmore was the first to describe endocarditis in melioidosis in 1913, reporting a 39–year–old male with small left-sided valvular vegetations post-mortem. In our systematic review, there were 11 patients with endocarditis reported in the literature [ 1 , 5 , 17 , 19 , 24 , 25 , 26 , 27 , 28 ]; six had adequate data for inclusion [ 5 , 24 , 25 , 26 , 27 , 28 ]. All six patients were males with an age range between 29 to 73 years and a mean age of 55.7 years.…”

Section: Resultsmentioning

confidence: 99%

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Melioidosis and the Heart: A Systematic Review

Velusamy

Muhi

2020

TropicalMed

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Melioidosis is caused by Gram-negative bacterium Burkholderia pseudomallei. Clinical presentation can vary from pneumonia, sepsis and multi-focal abscess formation. The aim of this study was to systemically review the cardiac manifestations of melioidosis in the literature and describe their epidemiology, microbiological diagnosis and outcomes. A systematic review of the peer-reviewed literature was carried out in PubMed and Google Scholar for human melioidosis cases with cardiac involvement. Quantitative data for cases of melioidosis were obtained, including age, sex, microbiological diagnosis, treatment, and outcome. 980 articles were screened, of which 31 articles were eligible. The most common cardiac site of infection was pericarditis, followed by endocarditis and myocarditis. Over 95% of cardiac involvement occurred in males, and mortality was the lowest in pericarditis and highest in myocarditis. Valvular vegetations were all small, left-sided, and did not require surgery. Antibiotic treatment included a bactericidal induction therapy with ceftazidime or a carbapenem ± TMP-SMX, followed by eradication therapy with TMP–SMX in most patients as previously established. In conclusion, melioidosis varies in clinical presentation and is also known as a great imitator. Although cardiac involvement is rare, this is the first systematic review to summarise all cases reported in the literature to date.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Melioidosis and the Heart: A Systematic Review

Velusamy

Muhi

2020

TropicalMed

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“…The worldwide incidence of melioidosis is unclear likely due to underrecognition and the lack of diagnostic resources in rural areas where the disease is prevalent [ 2 ]. Sporadic cases have been reported all over the globe, and <100 acquired cases were reported in the Americas from 1947 to 2015 [ 6 ]. Twelve melioidosis cases were identified in Panama between 2007 and 2017, but no prostate involvement was described [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, primary prostatic melioidosis cases have been rarely reported among tourists returning from endemic areas in Southeast Asia [ 4 , 5 ]. However, no prior cases of primary prostatic melioidosis have been reported from Panama [ 6 ]. We present a case of primary prostatic abscess due to B pseudomallei in a traveler returning from Panama.…”

mentioning

confidence: 99%

A Case Report of Melioidotic Prostatic Abscess in a Traveler

Verdecia

Jankowski

Isache

et al. 2022

Open Forum Infectious Diseases

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A 48-year-old-man who returned from Panama 5 weeks prior presented with fever, dysuria, hematuria, flank pain, and suprapubic pain and was found to have a prostatic abscess. Abscess fluid obtained during transurethral drainage grew Burkholderia pseudomallei. Blood cultures remained negative, and imaging did not show any other visceral abscess. This presentation of primary prostatic melioidosis is extremely rare in this region. Keywords: Melioidosis; Burkholderia pseudomallei; Prostatic abscess; traveler-related disease, Meropenem; Trimethoprim-sulfamethoxazole

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“…19 The same holds true for Panama, 12 cases were identified between 2007 and 2017, suggesting possible endemicity and increased need for surveillance although it has to be mentioned that numbers are low. 20 From the published literature alone, a review recently reported 63 cases of melioidosis from Mexico, central America, and the Caribbean, establishing its endemicity within the region. 21 An excellent example of uncovering the hidden burden using increased surveillance, awareness, and WHO's laboratory capacity building program is that from Sri Lanka.…”

Section: Global Burdenmentioning

confidence: 99%

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

Virk

Mukhopadhyay

Wiersinga

2020

Semin Respir Crit Care Med

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AbstractMelioidosis, caused by the facultative intracellular gram-negative pathogen Burkholderia pseudomallei, is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of B. pseudomallei in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Innovative environmental studies are also uncovering how hydrodynamic, pedology, fauna, and weather events influence geographic distribution and incidence of melioidosis cases. Of concern is the changes associated with global warming, which will be conducive to B. pseudomallei in combination with the global diabetes pandemic. In fact, over 80% of patient developing melioidosis have underlying comorbidities. For this great mimicker, culture remains the mainstay of diagnosis and despite availability of other assays, challenges still remain in reducing time to diagnosis and avoiding misdiagnosis. With institution of timely antimicrobials such as ceftazidime and supportive intensive care, overall mortality can be reduced to 10%, although this can still be as high as 50% in poorly resourced areas. Promise is on the horizon with the first human vaccine trials being planned for 2021. Meanwhile new multiomics techniques are giving us a better understanding of the role of virulence and host–pathogen interactions on patient outcomes.

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Geographic Distribution and Incidence of Melioidosis, Panama1

Cited by 7 publications

References 13 publications

Melioidosis and the Heart: A Systematic Review

Melioidosis and the Heart: A Systematic Review

A Case Report of Melioidotic Prostatic Abscess in a Traveler

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia

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