Geographic Differences in the Risk of Insulin-dependent Diabetes Mellitus: The Importance of Registries

LaPorte, Ronald E.; Tajima, Naoko; Åkerblom, Hans K.; Berlin, Nina; Brosseau, James D.; Christy, M.; Drash, Allan L.; Fishbein, Howard; Green, Anders; Hamman, Richard F.; Harris, Maureen I.; King, Hilary; Laron, Zvi; Neil, Andrew

doi:10.2337/diacare.8.1.s101

Cited by 197 publications

(105 citation statements)

References 6 publications

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“…The present registry was developed according to the standardised approach discussed by LaPorte [8] permitting comparison with registries at the international level. To estimate the degree of ascertainment, we used the capture-recapture methodology which yields much better estimates of the actual incidence than by not using any secondary source.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects 0–14 years of age in the Comunidad of Madrid, Spain

et al. 1990

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Summary.A retrospective, population-based registry was established in the Comunidad of Madrid, Spain (total population: 4,780,572; under age 15: 1,105,243) to investigate the epidemiology of Type 1 (insulin-dependent) diabetes mellitus. Included were all cases diagnosed with diabetes between 1985 and 1988, with age onset less than 15 years, and using insulin at discharge from hospital. Using the capture-recapture method employing hospital records as the primary source and membership files of the Spanish Diabetic Association as the secondary source, the ascertainment was 90%. The overall annual incidence was estimated to be 11.3/100,000 (Poisson 95% confidence interval: 10.3-12.4). There was no ternporal increase in incidence, nor was there a significant sex difference in incidence rates, either overall or by year. The seasonal onset pattern showed the highest incidence in winter (December-February) and lowest in summer (June-August) (r = 7.36,p < 0.05). The age-adjusted (world standard) incidence of 10.9/100,000 was inconsistent with the hypothesis of a north-south gradient in diabetes risk.

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Section: Discussionmentioning

confidence: 99%

Incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects 0–14 years of age in the Comunidad of Madrid, Spain

et al. 1990

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“…A large number of registries had been established since the mid 1980 s worldwide. The lack of standardized data made it difficult to determine the true magnitude of the worldwide variation in incidence or time trends [9]. The Di- Diabetologia (1999) Abstract Aims/hypothesis.…”

mentioning

confidence: 99%

Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends

Onkamo¹,

Väänänen²,

Karvonen³

et al. 1999

Diabetologia

765

513

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The aetiology and natural history of Type I (insulindependent) diabetes mellitus are still not known but both genetics and environmental factors contribute to the development of the disease [1±3]. Although HLA genetics have a major role in the aetiology of Type I diabetes, other genes also contribute to the genetic effect, but the mode of inheritance of the disease is not clear [4]. The genetic effect contributes 70±75 % of the susceptibility to Type I diabetes [5,6]. Environmental factors possibly initiate or trigger the process which leads to the destruction of the beta cells and the onset of diabetes [3,7,8].In the late 1970 s epidemiological reports of diabetic children for the first time showed a wide geographical variation in the incidence of Type I diabetes. During the 1960 s to the early 1980 s the data on incidence of Type I diabetes were available for a few populations only, mostly from regions with a high or intermediate risk for this disease. A large number of registries had been established since the mid 1980 s worldwide. The lack of standardized data made it difficult to determine the true magnitude of the worldwide variation in incidence or time trends [9]. The Di- Diabetologia (1999) Abstract Aims/hypothesis. Several reports on the incidence of Type I (insulin-dependent) diabetes mellitus have suggested that the incidence is increasing. The aim of this study was to find out whether the incidence is increasing globally or restricted to a selected populations only and to estimate the magnitude of the change in incidence. Methods. During 1960 to 1996 37 studies in 27 countries were carried out. To fulfil the inclusion criteria the study periods ranged from 8±32 years. The temporal trend was fitted by linear regression, with the logarithm of the age-standardized incidence as the dependent variable and the calendar year as the independent variable. Then, the regression coefficient (´100 %) is approximately the average relative increase in incidence per year (as percentage). Results. Results from the pooled data from all 37 populations showed that the overall increase in incidence was 3.0 % per year (95 % CI 2.6; 3.3, p = 0.0001). The statistically significant increase was found in 24 of 37 populations including all high incidence ( > 14.6 per 100 000 a year) populations. The relative increase was, however, steeper in the populations with a lower incidence. The correlation between logarithm of the incidence and the increase in incidence was r = ±0.56, p = 0.0004. Conclusion/interpretation. The incidence of Type I diabetes is increasing worldwide both in low and high incidence populations. By the year 2010 the incidence will be 50 per 100 000 a year in Finland and also in many other populations it will exceed 30 per 100 000 a year. [Diabetologia (1999

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“…This prospective populationbased register satisfies the criteria of the Diabetes Epidemiology International Group [13], enabling an international comparison of incidence rates. The database also contains retrospective data, obtained using multiple sources, on children diagnosed with Type 1 diabetes from 1985 to 1987.…”

Section: Methodsmentioning

confidence: 99%

Continued increase in the incidence of childhood Type 1 diabetes in a population-based Australian sample (1985?2002)

et al. 2004

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Geographic Differences in the Risk of Insulin-dependent Diabetes Mellitus: The Importance of Registries

Cited by 197 publications

References 6 publications

Incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects 0–14 years of age in the Comunidad of Madrid, Spain

Incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects 0–14 years of age in the Comunidad of Madrid, Spain

Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends

Continued increase in the incidence of childhood Type 1 diabetes in a population-based Australian sample (1985?2002)

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