Geographic and breed distribution of an <i>Msp</i> I PCR‐RFLP in the bovine growth hormone (bGH) gene

Lagziel, Ayala; DeNise, S.K.; Hanotte, Olivier; Dhara, Sujoy K.; Glazko, V. I.; Broadhead, A.; Davoli, Roberta; Russo, Vincenzo; Soller, M.

doi:10.1046/j.1365-2052.2000.00622.x

Cited by 30 publications

(31 citation statements)

References 9 publications

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“…Most Zebu breeds have a α S1 -cas C gene frequency of about 0.9, whereas it is very unusual for European breeds to have a gene frequency above 0.5 for this variants, and it is usually around 0.1 or less in the North-European and Pied Lowland breeds. Besides, in Bos taurus, the GH locus was found to have two alleles, whereas it was monomorphic (allele L only) in Zebu breeds (Lagziel et al, 2000;Arranz Santos, 1994;Kemenes et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…At locus GH, the breed frequencies of allele GH A, as related to their geographical origin, show a low frequency for breeds stemming from Northern Europe, moderate frequencies for breeds from Eastern Europe or the countries surrounding the Mediterranean basin, and very high frequencies for breeds from the Indian subcontinent (Lagziel et al, 2000). The GH A range of gene frequencies found in Argentine and Bolivian Creole (0.757-1.00), Iberian (0.396-0.955), and other South-American Creole cattle breeds were overlapping (Arranz Santos, 1994;Arranz Santos et al, 1996;Kemenes et al, 1999;Reis et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

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Analysis of genetic diversity and population structure in Argentine and Bolivian Creole cattle using five loci related to milk production

et al. 2002

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Data from five protein-coding loci related to dairy production were used to study the genetic diversity and population structure of Argentine and Bolivian Creole cattle breeds. Genomic DNA was extracted from blood samples of six Creole cattle breeds: Argentine (n = 230), Patagonian (n = 25); "Saavedreño" (n = 140), "Chaqueño Boliviano" (n = 30), "Yacumeño" (n = 27), and "Chusco" (n = 11). κ-casein, β-lactoglobulin, growth hormone and prolactin were measured by PCR-RFLP, while α S1 -casein was typed by PCR-ASO. The results are discussed, focusing on: historical origin, recent differentiation and selection events, Zebu gene introgression, and population structure. This work shows that: (i) For the studied genes, the observed gene frequency profiles of Argentine and Bolivian Creole cattle breeds were close to the data reported for Iberian breeds and for other South-American Creole cattle breeds which are historically related; (ii) although Zebu gene introgression has been reported at the studied loci, these breeds seem to be far from the Zebu gene frequency profiles; and (iii) the Argentine and Bolivian Creole cattle showed significant levels of subdivision, but each population has maintained its degree of genetic variability.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of genetic diversity and population structure in Argentine and Bolivian Creole cattle using five loci related to milk production

et al. 2002

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“…It has been shown that the MspI ( -) allele frequencies in zebu cattle are different (relatively high frequencies) from those reported for taurine breeds (Bos taurus) from northern Europe, Mediterranean countries, and North America. For instance, 0.000 and 0.026 were reported in the Holstein breed (Zhang et al, 1993a;Lagziel et al, 2000;Zhou et al, 2005), 0.000 in Hereford and in N'Dama, 0.150 in Jersey, 0.140 in Angus, 0.190 in Red Danish (Lagziel et al, 2000), and 0.050 in Norwegian Red and in Red Danish (Høj et al, 1993). Table 4 suggests that the frequency range of the MspI ( -) allele is 0.100 and 0.390 for cattle breeds of northern Europe, the United States, Europe, and the Mediterranean (Lagziel et al, 2000;Öner et al, 2011), but 0.670 to 0.940 in indicine (zebu) cattle breeds (Sodhi et al, 2007).…”

Section: Gh-mspi and Gh-alui Polymorphismsmentioning

confidence: 99%

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

Ünal¹,

Kepenek²,

Dinç³

et al. 2015

Turk J Zool

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IntroductionGenetic research in farm animals focuses mainly on the identification of genes influencing economically important traits that could be useful in breeding programs. In dairy cattle, most studies have researched the genes that may determine variations in milk yield and milk composition (Komisarek and Dorynek, 2009). The polymorphisms of several genes including growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) have been shown to affect milk yield and milk composition traits in dairy cattle.GH belongs to a family of somatolactogenic hormones including prolactin, placental lactogen, and a number of hematopoietic growth factors (Cosman et al., 1990). GH is located on the 19th chromosome in the q26-qter band region (Hediger et al., 1990). The GH gene of cattle is approximately 1800 bp in size and contains 5 exons and 4 introns. This gene encodes an mRNA with a size of 786 bp (Woychik et al., 1982). Although a number of polymorphisms have been observed in the GH gene of cattle, the 2 polymorphisms that are located in intron 3 and exon 5 have been found to be significant in their effects on milk and meat yield parameters (Lucy et al., 1991(Lucy et al., , 1993Høj et al., 1993). The polymorphism in intron 3 of GH is observed when GH is digested by the restriction enzyme MspI (GH-MspI) (Zhang et al., 1993). Two alleles are observed as a result of digestion with this enzyme. The first allele, GH-MspI ( -) contains a T insertion at the +837 position, and the second allele has a C-G transition at the +837 position (Lee et al., 1994). Zhang et al. (1993b) reported that the polymorphism in exon 5 could be observed when digested by the AluI enzyme (GH-AluI) and the 2 alleles called L (leucine in the 127th codon) and V (valine in the 127th codon) occur.The PRL gene is located on chromosome 23 and is composed of 5 exons and 4 introns (Camper et al., 1984, as cited by Skinkyte et al., 2005. A silent A-G mutation of the 103rd codon in exon 3 of the bovine PRL gene led to a polymorphic RsaI site (Lewin, 1992, as cited by Skinkyte et al., 2005). The polymorphism leading to the RsaI enzyme restriction site of the bovine PRL gene determines milk production traits including milk yield, milk fat, and milk protein contents (Lewin et al., 1992). The significant effect of the PRL locus on milk production traits was later shown by Chung et al. (1996, as cited by Dybus, 2002a as well.

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“…Various investigations revealed associations between GH-MspI polymorphism and both famele and male reproductive traits [48][49][50] . At the same time, it was observed that the distribution of this polymorphism obviously differed between geographic regions [51,52] . The A allele was predominant among breeds from Europe while the frequency of B allele was higher among Bos indicus cattle [51,52] .…”

Section: As It Is Seen Inmentioning

confidence: 84%

“…At the same time, it was observed that the distribution of this polymorphism obviously differed between geographic regions [51,52] . The A allele was predominant among breeds from Europe while the frequency of B allele was higher among Bos indicus cattle [51,52] . The B allele was found related to meat quality and the lower frequencies of the allele among HolsteinFrisian cows were explained with this finding [23] .…”

Section: As It Is Seen Inmentioning

confidence: 84%

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Öner¹,

Yılmaz²,

Okut³

et al. 2017

Kafkas Univ Vet Fak Derg

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In this study, it was aimed to investigate polymorphisms in seven genes (GH, PRL, STAT5A, OPN, LEP and FGF2) related to reproductive traits in dairy heifers. Frequency distributions of the genotypes between fertile and repeat breeder heifers groups were investigated. Allele effects on fertility were also analyzed. Blood samples were taken from a total of 160 Holstein-Friesian heifers and they were divided into two groups according to their artificial insemination numbers (AI). The heifers becoming pregnant after the first AI were used as the fertile heifers (FH, n=80) and the heifers with 3 or more equal AIs were accepted as the repeat breeder heifers (RBH, n=80). All the animals were genotyped by the PCR-RFLP method for seven genes and the association works were performed for 145 animals (RBH, n=79; FH n=66). For all loci investigated, two alleles and three genotypes were found for overall population with the exception that PRL locus had two alleles and two genotypes. The chi-square test (χ 2 ) revealed that the whole population and the two groups separately were at Hardy-Weinberg equilibrium. The genotype distributions of PIT-1 and STAT5A conspicuously differed between the FH and the RBH groups; however, these differences were not found significant. Association of GH-AB genotype was found significant on AI number for the first pregnancy. Mixed effect logistic regression model was used to investigate the allele effects on fertility. No linkage disequilibrium was detected between the investigated loci. Keywords

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Geographic and breed distribution of an Msp I PCR‐RFLP in the bovine growth hormone (bGH) gene

Cited by 30 publications

References 9 publications

Analysis of genetic diversity and population structure in Argentine and Bolivian Creole cattle using five loci related to milk production

Analysis of genetic diversity and population structure in Argentine and Bolivian Creole cattle using five loci related to milk production

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

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