Geoclimatic risk factors for childhood asthma hospitalization in southwest of Iran

Kanannejad, Zahra; Shomali, Mohammad; Esmaeilzadeh, Hossein; Nabavizadeh, Hesamodin; Nikaein, Koorosh; Ghahramani, Zahra; Ghatee, Mohammad Amin; Alyasin, Soheila

doi:10.1002/ppul.25971

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…The authors found a significant correlation between urban residence and asthma hospitalization, however, did not find a significant correlation with climate variables such as mean annual evaporation, mean annual humidity, mean annual rainfall, or mean annual temperature. 8 These findings provide additional knowledge of the growing influence of climate change and social determinants of health on asthma care.…”

Section: Updates On Risk Factors For Asthmamentioning

confidence: 85%

Pediatric pulmonology 2022 year in review: Asthma

Stephenson,

Espaillat,

Loughlin

2023

Pediatric Pulmonology

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In 2022, new research studies influenced the field of pediatric asthma with improvements in diagnosis and evaluation; new treatment options including biologic therapies; changes in risk factors for asthma; and increased discussion about the impact of social determinants of health on asthma. Additionally, three years after the start of the COVID‐19 pandemic, we continue to see the impact of SARS‐CoV‐2 virus on pediatric asthma care. In this review article, we summarize the significant findings from publications in Pediatric Pulmonology and other relevant journals from the last year. We hope this review will provide new insight within the field of pediatric asthma, as well as guidance for implementation into clinical practice.

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Section: Updates On Risk Factors For Asthmamentioning

confidence: 85%

Pediatric pulmonology 2022 year in review: Asthma

Stephenson,

Espaillat,

Loughlin

2023

Pediatric Pulmonology

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“…Similar to our results, Solé et al (2007) reported higher asthma prevalence among adolescents living in urban areas compared to the rural ones in Brazil. We previously found increased asthma hospitalization occurrences in urban regions of Fars province compared with rural areas (Kanannejad et al, 2022). The farming environment of rural areas is one explanation for lower asthma prevalence in such places (Strachan, 1989).…”

Section: Environmental Factorsmentioning

confidence: 90%

“…The slope was another significant environmental factor affecting acute asthma occurrence in Fars province, where more asthma hospitalization was detected in areas with a lower pitch. Our previous study on childhood populations showed the powerful effect of slope on asthma hospitalization (Kanannejad et al, 2022). It may be related to higher population density in regions with a downward slope that usually is connected with increased air pollutants, nanoparticles, and transmissible infectious viral agents (Bröms et al, 2009).…”

Section: Environmental Factorsmentioning

confidence: 97%

“…In this way, the Geographical Information System (GIS), a computer system that analyzes and displays geographically referenced information, can be helpful for health scientists to determine the effects of geo-climatic parameters on disease prevalence and occurrence (Aghajani et al, 2017;Ghatee et al, 2020a;Pande et al, 2021;Gautam et al, 2022). In the context of asthma, there are limited GIS-based studies showed a direct association between asthma occurrence and vegetation land cover (Khan et al, 2010), allergens (Keddem et al, 2015), plant pollens (Maya-Manzano et al, 2017), pollution (Gorai et al, 2014) and urban settings (Kanannejad et al, 2022). For acute asthma, remote-sensing and GIS methods help researchers to show nitrogen dioxide (NO 2 ), Normalized Difference Vegetation Index (NDVI), and near-surface air temperature (Ta) as the main determinants of hospital admission due to asthma (Almeida et al, 2017).…”

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confidence: 99%

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Geo-climatic variability and adult asthma hospitalization in Fars, Southwest Iran

Kanannejad

Shokri

Alyasin

et al. 2023

Front. Environ. Sci.

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Asthma is a chronic respiratory disease resulting from a complex interaction between genetic and environmental factors. Many environmental factors have been associated with incidence or prevalence of asthma although there is still limited knowledge of major environmental causes of asthma in the general population. This study, for the first time, investigated the effects of climatic and geographical variability on asthma hospitalization among an adult population living in Fars province, southwest Iran. During the study period, the home addresses of patients hospitalized with acute asthma from 2016 to 2019 were mapped. The effects of geo-climatic factors including temperature, rainfall, humidity, evaporation, number of rainy and frosty days, slope, and land covers were assessed on adult asthma hospitalization by Geographical Information System (GIS). Data were analyzed using univariate and multivariate binary logistic regression. A total of 349 patients were recruited, including 157 (44.98%) males and 192 (55%) females. The mean age was 57.77 ± 18.84 years, ranging from 19 to 98 years. Asthmatic patients came from a total of 82 points including villages, towns, and cities. In the univariate analysis, urban setting (OR = 13) and Mean Annual Rainy Days (OR = 1.03) were identified as the factors associated with increased asthma hospitalization, while Mean Annual Temperature (MAT) (OR = 0.927), MinMAT (OR = 0.933), MaxMAT (OR = 0.925), Mean Annual Evaporation (MAE) (OR = 0.999), and slope (OR = 0.925) negatively affected asthma hospitalization. Urban setting was considered the only significant factor in multivariate analysis (OR = 11.026). The major risk zones for adulthood acute asthma in southwest Iran were urban settings and areas with higher numbers of rainy days, lower temperatures, and evaporation at lower slopes.

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“…Asthma is characterized by airway obstruction, inflammation, and remodeling. The development of this disease is influenced by a complex interplay between genetic and environmental factors, along with the involvement of diverse immune and nonimmune cells 2–4 . Asthma inflammation involves the interaction and secretion of soluble mediators by various cell types, including immune cells (such as mast cells, eosinophils, and T cells) as well as structural cells (such as epithelial and endothelial cells, and fibroblasts).…”

Section: Introductionmentioning

confidence: 99%

Exosomes in asthma: Underappreciated contributors to the pathogenesis and novel therapeutic tools

Kanannejad,

Arab,

Soleimanian

et al. 2024

Immunity Inflam & Disease

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ObjectiveAsthma, a chronic inflammatory disease with diverse pathomechanisms, presents challenges in developing personalized diagnostic and therapeutic approaches. This review aims to provide a comprehensive overview of the role of exosomes, small extracellular vesicles, in asthma pathophysiology and explores their potential as diagnostic biomarkers and therapeutic tools.MethodsA literature search was conducted to identify recent studies investigating the involvement of exosomes in asthma. The retrieved articles were analyzed to extract relevant information on the role of exosomes in maintaining lung microenvironment homeostasis, regulating inflammatory responses, and their diagnostic and therapeutic potential for asthma.ResultsExosomes secreted by various cell types, have emerged as crucial mediators of intercellular communication in healthy and diseased conditions. Evidence suggest that exosomes play a significant role in maintaining lung microenvironment homeostasis and contribute to asthma pathogenesis by regulating inflammatory responses. Differential exosomal content between healthy individuals and asthmatics holds promise for the development of novel asthma biomarkers. Furthermore, exosomes secreted by immune and nonimmune cells, as well as those detected in biofluids, demonstrate potential in promoting or regulating immune responses, making them attractive candidates for designing new treatment strategies for inflammatory conditions such as asthma.ConclusionExosomes, with their ability to modulate immune responses and deliver therapeutic cargo, offer potential as targeted therapeutic tools in asthma management. Further research and clinical trials are required to fully understand the mechanisms underlying exosome‐mediated effects and translate these findings into effective diagnostic and therapeutic strategies for asthma patients.

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Geoclimatic risk factors for childhood asthma hospitalization in southwest of Iran

Cited by 4 publications

References 34 publications

Pediatric pulmonology 2022 year in review: Asthma

Pediatric pulmonology 2022 year in review: Asthma

Geo-climatic variability and adult asthma hospitalization in Fars, Southwest Iran

Exosomes in asthma: Underappreciated contributors to the pathogenesis and novel therapeutic tools

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