Genus Tabebuia: A comprehensive review journey from past achievements to future perspectives

El‐Hawary, Seham S.; Taher, Marwa A.; Amin, Elham; AbouZid, Sameh; Mohammed, Rabab

doi:10.1016/j.arabjc.2021.103046

Cited by 17 publications

(16 citation statements)

References 136 publications

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“…Tabebuia spp. are also reported to have lower or no activity against Gram-negative bacteria [ 54 , 55 , 57 ]. It is hypothesized that the high activity of the complex against S. aureus is due to the combined anti-staphylococcal effect of all three extracts, but the ability to inhibit the growth of Gram-negative H. influenzae and K. pneumoniae is due to the broader antimicrobial activity of olive leaf extract.…”

Section: Discussionmentioning

confidence: 99%

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Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

et al. 2022

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Bacterial infections are a prevalent complication after primary viral respiratory infections and are associated with high morbidity and mortality. Antibiotics are widely used against bacterial respiratory pathogens; however, the rise in antibiotic-resistant strains urges us to search for new antimicrobial compounds, including ones that act synergistically with antibiotics. In this study, the minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations of a polyphenol-rich complex of green propolis, Tabebuia avellanedae bark, and Olea europaea leaf extracts against Staphylococcus aureus, Haemophilus influenzae, and Klebsiella pneumoniae were determined, followed by an analysis of the synergistic effect with clarithromycin, azithromycin, and amoxiclav (875/125 mg amoxicillin/clavulanic acid). A combination of extracts showed activity against all three bacterial strains, with MIC values ranging from 0.78 to 12.5 mg/mL and MBC values from 1.56 to 12.5 mg/mL. The extracts showed synergistic activity with azithromycin and clarithromycin against S. aureus, with clarithromycin against K. pneumoniae, and with all three tested antibiotics against H. influenzae. Synergy with clarithromycin was additionally evaluated in a time-kill assay where the synergistic effects against S. aureus and K. pneumoniae were seen within the first 6 h of incubation. The results show the potential of polyphenol-rich extracts in enhancing the efficacy of antibiotic therapy and indicate their potential to be used in the management of respiratory infections.

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Section: Discussionmentioning

confidence: 99%

“…Limited data are available about the mechanism of antimicrobial activity and its interaction with other antimicrobial substances. It is supposed that phenolic compounds of Tabebuia induce oxidative stress in the bacterial cell membrane and interfere with ATP synthesis [ 54 , 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

et al. 2022

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“…O lapachol (LP) é uma Naftoquinona (NFq) bioativa que pode ser extraída da serragem de árvores de Ipê roxo, facilmente encontradas no norte e nordeste brasileiro (Hussain et al, 2007). O estudo deste composto desperta o interesse das indústrias farmacêuticas devido a uma série de atividades biológicas, como: efeitos antitumorais, leishmanicidas, bactericidas, malaricidas, inibidores do HIV-1, antiinflamatórios, tripanocidas, antifúngicos, contra larvas Aedes aegypti, entre outras ((Brandão et al, 2018;El-Hawary et al, 2021;Medeiros et al, 2010;Pereira et al, 2006;Pertino et al, 2020). Além disso, estudos in vitro e in vivo têm reportado seu acentuado potencial como inibidor de metástase (Maeda et al, 2008;Mendes Miranda et al, 2021).…”

Section: Introductionunclassified

Interação Do Lapachol Com Nanoplataformas Micelares Drug Delivery

et al. 2021

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The high toxicity of several systemically administered drugs is due to low specificity to diseased cells. This results in adverse effects and discomfort to patients. A promising strategy to enhance the therapeutic efficacy and clinical use of activeingredients is their incorporation into nanostructured micellar systems. These nanocarriers are widely addressed in the literature as drug delivery systems. Thus, this paper discusses aspects related to the interaction capacity of the natural drug lapachol with two micellar systems (F127 and P123), aiming to obtain a new drug for systemic administration. For this, previous studies were conducted to evaluate the variations that the aggregation of lapachol results in its spectral behavior. Subsequently, the interaction of lapachol with drug delivery systems was investigated by monitoring the fluorescence emission spectra of the drug. In general, the results obtained were promising and enrich the current therapeutic arsenal with a new medicine proposal, whose drug has established ethnopharmacological and scientific recognition.

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“…De acordo com estudos de Hamed et al (2020) e El-Hawary et al (2021) família Bignoniaceae possui gêneros que as plantas apresentam diversas atividades farmacológicas já relatas na literatura, destaca-se nesse contexto a Tabebuia roseoalba.…”

Section: Introductionunclassified

“…Assim como compreender se as pesquisas de maneira geral estão sendo convertidas de fato para solução desses problemas, podendo contribuir para a redução de óbitos e gastos dos serviços de saúde. Diante desse contexto, o objetivo desse artigo foi realizar uma prospecção científica e tecnológica em busca de artigos e patentes com o uso de extrato natural como potencial antimicrobiano, tendo como ponto principal o uso da Tabebuia roseoalba (Hamed et al, 2020;El-hawary et al, 2021).…”

Section: Introductionunclassified

Prospecção científica e tecnológica da Tabebuia reseoalba (Ipê-branco)

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et al. 2021

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A Tabebuia roseoalba, conhecida popularmente como Ipê-branco, uma planta nativa do cerrado e pantanal brasileiro. Por possuir inúmeras substâncias de interesse terapêutico, há perspectivas de servirem como alternativa no controle de infecções. Com o intuito de verificar a importância dos extratos de Tabebuia roseoalba no cunho científico, foram feitas pesquisas a fim de se confirmar a relevância que o presente trabalho apresenta como inovação tecnológica. Os resultados encontrados nas bases de dados Science Direct e Pubmed, assim como patentes encontradas nos bancos de patentes World Intelectual Property Organization (WIPO) e Instituto Nacional da Propriedade Industrial (INPI), foram métodos eficazes para a construção dessa Prospecção. A partir das palavras-chaves antimicrobianos, resistência bacteriana, Bignoniaceae, Tabebuia e Tabebuia roseoalba, na língua inglesa e portuguesa, quando necessário, na base de patentes WIPO revelou 135.638 patentes para antimicrobial, 78.108 para bacterial resistence, 69 para Bignoniaceae, 167 para Tabebuia e 0 para Tabebuia roseoalba. No INPI foram obtidas 1.377 para antimicrobiano, 2.510 para resistência bacteriana, 38 para Bignoniaceae, 31 para Tabebuia e 3 para Tabebuia roseoalba. A partir dos resultados obtidos mediante as buscas de patentes acerca da utilização de potenciais antimicrobiano de Tabebuia roseoalba para o combate de agentes patogênicos, pode-se concluir que o estudo forneceu dados de prospecção científico-tecnológico, visto que auxiliou como uma boa ferramenta para a realização da presente pesquisa pode-se ressaltar a importância da análise prospecção tecnológica, como um meio benéfico no qual pode promover a capacidade de organizar a pesquisa inovadora com base nos interesses e necessidades da sociedade.

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Genus Tabebuia: A comprehensive review journey from past achievements to future perspectives

Cited by 17 publications

References 136 publications

Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

Interação Do Lapachol Com Nanoplataformas Micelares Drug Delivery

Prospecção científica e tecnológica da Tabebuia reseoalba (Ipê-branco)

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