Genus Ophiorrhiza: A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation

Taher, Muhammad; Shaari, Siti Syazwani; Susanti, Deny; Аrbаin, Dаyаr; Zakaria, Zainul Amiruddin

doi:10.3390/molecules25112611

Cited by 25 publications

(11 citation statements)

References 54 publications

(118 reference statements)

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“…In addition, the accepted authority of the plant species was referred from theplantlist.org . The layout of the searching methodology is presented in Figure 1 as adapted from Taher et al (2020) .…”

Section: Methodsmentioning

confidence: 99%

Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review

et al. 2022

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The genus Alocasia (Schott) G. Don consists of 113 species distributed across Asia, Southeast Asia, and Australia. Alocasia plants grow in tropical and subtropical forests with humid lowlands. Featuring their large green heart-shaped or arrow-shaped ear leaves and occasionally red-orange fruit, they are very popular ornamental plants and are widely used as traditional medicines to treat various diseases such as jaundice, snake bite, boils, and diabetes. This manuscript critically analysed the distribution, traditional uses, and phytochemical contents of 96 species of Alocasia. The numerous biological activities of Alocasia species were also presented, which include anti-cancer, antidiabetic and antihyperglycaemic, antioxidant, antidiarrhoea, antimicrobial and antifungal, antiparasitic (antiprotozoal and anthelminthic), antinociceptive and anti-inflammatory, brine shrimp lethality, hepatoprotective, anti-hemagglutinin, anti-constipation and diuretic, and radioprotective activities as well as acute toxicity studies. Research articles were acquired by the accessing three scientific databases comprising PubMed, Scopus, and Google Scholar. For this review, specific information was obtained using the general search term “Alocasia”, followed by the “plant species names” and “phytochemical” or “bioactivity” or “pharmacological activity”. The accepted authority of the plant species was referred from theplantlist.org. Scientific studies have revealed that the genus is mainly scattered throughout Asia. It has broad traditional benefits, which have been associated with various biological properties such as cytotoxic, antihyperglycaemic, antimicrobial, and anti-inflammatory. Alocasia species exhibit diverse biological activities that are very useful for medical treatment. The genus Alocasia was reported to be able to produce a strong and high-quality anti-cancer compound, namely alocasgenoside B, although information on this compound is currently limited. Therefore, it is strongly recommended to further explore the relevant use of natural compounds present in the genus Alocasia, particularly as an anti-cancer agent. With only a few Alocasia species that have been scientifically studied so far, more attention and effort is required to establish the link between traditional uses, active compounds, and pharmacological activities of various species of this genus.

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Section: Methodsmentioning

confidence: 99%

Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review

et al. 2022

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“…Isomalindine 113 and normalindine 111 were isolated from Ophiorrhiza sp. [ 132 ]. 19- O -ethylangustoline 99 and other alkaloids were isolated from the stem bark of Sarcocephalus latifolius [ 133 ].…”

Section: Naturally Occurring Naphthyridine Derivativesmentioning

confidence: 99%

“…Normalindine 111 and norisomalindine 110 were isolated from Strychnos johnsonii[131]. Isomalindine 113 and normalindine 111 were isolated from Ophiorrhiza sp [132]…”

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confidence: 99%

Biological Activity of Naturally Derived Naphthyridines

2021

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Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

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“…The Rubiaceae plant family has served as an important source of bioactive compounds and “leads” for drug discovery and development (Buathong et al 2019 ; Koehbach et al 2013 ; Maldonado et al 2017 ; Wijnsma and Verpoorte 1986 ). While other genera within the Rubiaceae family have received considerable research attention as well as reviews on their species (Fan et al 2020 ; Gibbons 2020 ; Heitzman et al 2005 ; Kala 2015 ; Taher et al 2020 ) which has stimulated further research, Psydrax genus has been underexplored scientifically; the genus has not been previously reviewed to reveal knowledge gaps and provide opportunities for further studies.…”

Section: Introductionmentioning

confidence: 99%

Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

2022

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The genus Psydrax is one of the ethno-medicinally important genera of the Rubiaceae family which has only received a limited scientific attention, despite coming from a pharmacologically and phytochemically important plant family. The genus has found applications in ethnomedical management of diabetes, stomach disorders, inflammations, cardiovascular diseases, epilepsy, wounds, malaria and fever. To unveil knowledge gaps, stimulate research interest and unravel opportunities for drug discovery from the genus Psydrax , we have carried out an extensive review on its traditional applications, phytochemistry and pharmacology for the first time. Literature on these topics was obtained from Google Scholar, Pubmed and ScienceDirect journal articles published from 1788 to September, 2021. Only articles written in English were reviewed. While several species of Pysdrax used in traditional medicine have not been chemically explored for drug discovery, over a hundred secondary metabolites have so far been identified in few species of the genus, and majority of these chemotaxonomic markers are iridoids. Bioactive extracts and some isolated constituents of Psydrax species have shown various in vitro and in vivo pharmacological properties including anti-hyperglycemia, anti-inflammatory, anticonvulsant and antimicrobial, and thus, support some of the ethnomedical uses of the plants. For an evidence-informed application of the genus, Psydrax , in traditional medicine, more ethnobotanical surveys, elaborate in vivo pharmacological assays, in-depth toxicity and holistic phytochemical studies are required to fully exploit more species of the genus prior to future clinical studies. Following documented traditional uses of Psydrax species, the deliberate cultivation of medicinal plants under this genus is recommended for sustainability in medicinal plant utilization.

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Genus Ophiorrhiza: A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation

Cited by 25 publications

References 54 publications

Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review

Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review

Biological Activity of Naturally Derived Naphthyridines

Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

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