Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism

Jiang, Min; Cui, Ben-Wen; Wu, Yan-Ling; Nan, Ji‐Xing; Lian, Li-Hua

doi:10.1016/j.jep.2020.113391

Cited by 44 publications

(37 citation statements)

References 115 publications

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“…To date, most phytochemical studies have mainly focused on the Gentiana and Swertia genera. Nearly 600 metabolites were identified from the Gentiana genus [56][57][58] and more than 400 metabolites were identified from the Swertia genus [59][60][61][62]. The primary bioactive components isolated from the two genera include iridoids, xanthones, flavonoids, and triterpenoids, of which a few are alkaloids, lignans, and phenolic compounds.…”

Section: Phytochemistry Of Gentianeaementioning

confidence: 99%

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

Chi

Zhang

Gao

et al. 2021

Plants

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Gentianaceae is a large plant family and is distributed worldwide. As the largest tribe in Gentianaceae, Gentianeae contains 939–968 species, and the Qinghai-Tibet Plateau and adjacent areas are the main centers of diversity for Gentianeae. Species from the Gentianeae are widely used in traditional Tibetan medicine. In this review, a systematic and constructive overview of the information on botany, ethnomedicinal usage, phytochemistry, and pharmacological properties of Gentianeae in Tibetan medicine is provided. The results of this study are based on a literature search, including electronic databases, books, websites, papers, and conference proceedings. Botanical studies showed that Gentianeae includes the subtribe Gentianeae and Swertiinae, and several new genera and taxa have been identified. Approximately 83 species from Gentianeae were used in Tibetan medicine, among which Gentiana and Swertia constituted the largest number of species with 42 and 24 species, respectively. The species from Gentianeae are mainly used as Bangjian (སྤང་རྒྱན།), Jieji (ཀྱི་ལྕེ།), Dida (ཏིག་ཏ།), and Ganggaqiong (གང་གྰཆུང་།) in Tibetan medicine with different clinical applications. More than 240 formulas were found containing Gentianeae species with different attending functions. Phytochemical studies showed that the main active components of Gentianeae species are iridoids, xanthones, flavonoids, and triterpenoids. The bioactivities of plants from Gentianeae include hepatic protection, upper respiratory tract protection, joint and bone protection, glucose regulation, antibacterial, antioxidant, anticancer, and antiviral effects. This review will provide a reference for future research on natural resource protection, plant-based drug development, and further clinical investigation.

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Section: Phytochemistry Of Gentianeaementioning

confidence: 99%

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

Chi

Zhang

Gao

et al. 2021

Plants

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“…Demethylbellidifolin, demethylbellidifolin-8-O-glucoside, bellidifolin-8-O-glucoside, and swertisin exhibited radioprotective effect; bellidifolin and demethylbellidifolin possess cardioprotective properties, while bellidifolin, bellidifolin-8-O-glucoside, swertizin, and isoorientin, besides antioxidant properties showed significant hypoglycemic activity. Overall, xanthones are recognized as hepatoprotective, hypolipidemic, anticholinesterase, and cerebral vasodilator agents (Jiang et al, 2021;Tchamo Diderot et al, 2006). Recently, a pharmacological study (Janković et al, 2008) involving radioprotective effects of G. austriaca ether and methanolic fractions and polyphenolic constituents (demethylbellidifolin and its 8-O-glucoside, as well as bellidifolin-8-Oglucoside and swertisin) in human lymphocytes was under- taken.…”

Section: The Comparative Study On Gentianella Albanica G Crispata and G Austriacamentioning

confidence: 99%

Comprehensive combined chemical and pharmacognostic approach in the investigation of Montenegrin flora, with emphasis on endemic species: Past performance and future potential

Menković¹,

Tadić²

2021

Lekovite sirovine

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Herein, we have reviewed the comparative analysis relating pharmacognostic and chemical approaches in the investigation of the chosen plants from Montenegrin flora known for the constituents recognized as carriers of different biological activities. In addition, some of the mentioned extensively studied plants were with uncertain status in the systematics, as not being recognized as new species. The results of pharmacognostic studies with the thorough chemical analyses addressing the problem in positioning some of the investigated plants from Swertia, Gentiana and Gentianella genera belonging to family Gentianaceae in systematics, performed within the collaboration of two research groups from Institute for Medicinal Plants Research "Dr. Josif Pančić" and Faculty of Chemistry, the University of Belgrade under the leadership of Dr. Nebojša Menković and Prof. Dr. Slobodan Milosavljević were summarized. In addition, the complete chemical structure elucidation of sesquiterpene lactones present in Anthemis sp. as potential anti-inflammatory agents, applying the sophisticated 2D NMR techniques was reviewed. Further, the parthenolide content determination in Tanacetum larvatum revealed the possibility of the successful application of 1 H NMR techniques in quantification studies. The findings presented in the published literature stressed the importance of a combined chemical and pharmacognostic approach in the investigation of natural products originating from plants.

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“…Bioactive components from natural medicines, a key source of lead compounds for the development of innovative drugs ( Kataura et al, 2021 ), have a wide range of biological activities ( Jiang et al, 2021 ), including antitumor, anti-inflammatory, and anti-infection activity. Many antitumor agents, such as vinblastine, paclitaxel, and ligustrazine (TMP), have been isolated from natural products.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents

Zhang

Hou

et al. 2022

Front. Chem.

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Ligustrazine (TMP) is a natural pyrazine alkaloid extracted from the roots of Ligusticum Chuanxiong Hort, which has the potential as an antitumor agent. A series of 33 ligustrazine–heterocycle (TMPH) derivatives were designed, synthesized, and investigated via antitumor screening assays, molecular docking analysis, and prediction of drug-like properties. TMP was attached to other heterocyclic derivatives by an 8–12 methylene alkyl chain as a linker to obtain 33 TMPH derivatives. The structures were confirmed by 1H-NMR, 13C-NMR, and high-resolution mass spectroscopy spectral (HR-MS) data. The antiproliferative activity against human breast cancer MCF-7, MDA-MB-231, mouse breast cancer 4T1, mouse fibroblast L929, and human umbilical vein endothelial HUVEC cell lines was evaluated by MTT assay. Compound 12–9 displayed significant inhibitory activity with IC50 values in the low micromolar range (0.84 ± 0.02 µM against the MDA-MB-231 cell line). The antitumor effects of compound 12–9 were further evaluated by plate cloning, Hoechst 33 342 staining, and annexin V-FITC/PI staining. The results indicated that compound 12–9 inhibited the proliferation and apoptosis of breast cancer cells. Furthermore, molecular docking of compound 12–9 into the active site of the Bcl-2, CASP-3, and PSMB5 target proteins was performed to explore the probable binding mode. The 33 newly synthesized compounds were predicted to have good drug-like properties in a theoretical study. Overall, these results indicated that compound 12–9 inhibited cell proliferation through PSMB5 and apoptosis through Bcl-2/CASP-3 apoptotic signaling pathways and had good drug-like properties. These results provided more information, and key precursor lead derivatives, in the search for effective bioactive components from Chinese natural medicines.

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Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism

Cited by 44 publications

References 115 publications

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

A Review on the Ethnomedicinal Usage, Phytochemistry, and Pharmacological Properties of Gentianeae (Gentianaceae) in Tibetan Medicine

Comprehensive combined chemical and pharmacognostic approach in the investigation of Montenegrin flora, with emphasis on endemic species: Past performance and future potential

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents

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