E. I. du Pont de Nemours & Co. is one of the world’s largest chemical corporations, and its operations are of interest to business historians. This article explores the early history of the firm within the context of early republic political economy in order to show how it came to a place of prominence in the American gunpowder market by the early 1820s. The article utilizes the archival and printed records of DuPont, associated firms, government correspondence, and early War Department and trade statistics to show how the company, unlike other powder mills of that time, had access to both large reserves of foreign capitalandthe halls of power in the federal government. These resources helped DuPont become a principal supplier of gunpowder to the army, the navy, and a major exporter during the War of 1812 era.