Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma

Ashidate, Keiko; Kawamura, Mitsunobu; Mimura, Daigo; Tohda, Hisako; Miyazaki, Shigeru; Teramoto, Tamio; Yamamoto, Yorihiro; Hirata, Yukio

doi:10.1016/j.ejphar.2005.03.012

Cited by 84 publications

(58 citation statements)

References 25 publications

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“…These fractions had very high amount of ferulic acid, gentisic acid and also good amount of gallic and protocatechuic acid. Ferulic acid and gentisic acid are reported to have potent free radical scavenging activities (Astidate et al, 2005;Brand-Williams et al, 1995;Shahidi & Wanasundara, 1992). Higher α-glucosidase inhibitory activity for seed coat, plumule and aleurone layer enriched in seed coat fractions are also due to the changes in phenolic acid composition.…”

Section: Correlation Of In Vitro Biological Activities With Bioactivementioning

confidence: 95%

Nutrient distribution, phenolic acid composition, antioxidant and alpha-glucosidase inhibitory potentials of black gram (Vigna mungo L.) and its milled by-products

Girish

Pratape

Rao

2012

Food Research International

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Section: Correlation Of In Vitro Biological Activities With Bioactivementioning

confidence: 95%

Nutrient distribution, phenolic acid composition, antioxidant and alpha-glucosidase inhibitory potentials of black gram (Vigna mungo L.) and its milled by-products

Girish

Pratape

Rao

2012

Food Research International

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“…These metabolites are upstream of the citric acid cycle and their decrease could be a means of shunting benzoate degradation into acetyl-CoA, and hence, the citric acid cycle, again consistent with the Warburg effect. Gentisate has also been shown to have electron-scavenging properties and may prevent oxidation of lipoproteins (Ashidate et al, 2005). Because cancer cells are highly metabolic, increasing gentisate levels within the cell may prevent oxidation of both cellular and organelle membranes.…”

Section: Discussionmentioning

confidence: 99%

Urine Metabolomic Analysis Identifies Potential Biomarkers and Pathogenic Pathways in Kidney Cancer

Kim

Taylor

Ganti

et al. 2011

OMICS: A Journal of Integrative Biology

137

111

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Kidney cancer is the seventh most common cancer in the Western world, its incidence is increasing, and it is frequently metastatic at presentation, at which stage patient survival statistics are grim. In addition, there are no useful biofluid markers for this disease, such that diagnosis is dependent on imaging techniques that are not generally used for screening. In the present study, we use metabolomics techniques to identify metabolites in kidney cancer patients' urine, which appear at different levels (when normalized to account for urine volume and concentration) from the same metabolites in nonkidney cancer patients. We found that quinolinate, 4-hydroxybenzoate, and gentisate are differentially expressed at a false discovery rate of 0.26, and these metabolites are involved in common pathways of specific amino acid and energetic metabolism, consistent with high tumor protein breakdown and utilization, and the Warburg effect. When added to four different (three kidney cancer-derived and one ''normal'') cell lines, several of the significantly altered metabolites, quinolinate, aketoglutarate, and gentisate, showed increased or unchanged cell proliferation that was cell line-dependent. Further evaluation of the global metabolomics analysis, as well as confirmation of the specific potential biomarkers using a larger sample size, will lead to new avenues of kidney cancer diagnosis and therapy.

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“…It was also shown that 3HB6H catalyzes the regio-specific para-hydroxylation of a number of 3-hydroxybenzoate analogs (10). Therefore, 3HB6H is potentially useful for synthesizing gentisate compounds that are drugs or antioxidants (15,16). Recently, the crystal structures of the wild-type and mutant 3HB6H enzymes were solved (17).…”

Section: °C) This Intermediate Is Subsequently Protonated To Form Amentioning

confidence: 99%

The Reaction Kinetics of 3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Provide an Understanding of the para-Hydroxylation Enzyme Catalytic Cycle

Sucharitakul

Tongsook

Pakotiprapha

et al. 2013

Journal of Biological Chemistry

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Background: 3-Hydroxybenzoate 6-hydroxylase (3HB6H) is a flavoprotein hydroxylase catalyzing the para-hydroxylation of 3-hydroxybenzoate. Results: The oxidative half-reaction was studied using transient kinetics. The enzyme reaction mechanism was elucidated. Conclusion:The product release and the hydroxylation limit the turnovers and the enzyme shows characteristics different from the ortho-hydroxylation enzymes. Significance: This is the first report on the oxygenation mechanism of a para-hydroxylating flavoenzyme.

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Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma

Cited by 84 publications

References 25 publications

Nutrient distribution, phenolic acid composition, antioxidant and alpha-glucosidase inhibitory potentials of black gram (Vigna mungo L.) and its milled by-products

Nutrient distribution, phenolic acid composition, antioxidant and alpha-glucosidase inhibitory potentials of black gram (Vigna mungo L.) and its milled by-products

Urine Metabolomic Analysis Identifies Potential Biomarkers and Pathogenic Pathways in Kidney Cancer

The Reaction Kinetics of 3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Provide an Understanding of the para-Hydroxylation Enzyme Catalytic Cycle

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