Gentamicin use in neonates: should we have a change of practice?

Krishnamoorthy, S; Nair, AM; Furness, John; Sanderson, Jeremy

doi:10.1177/0036933013507874

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Of concern is that almost 20% of gentamicin prescriptions were for an overdose and most were in preterm/low birthweight newborns with doses <50% above that recommended. Gentamicin is potentially ototoxic and nephrotoxic, 22 23 and drug level monitoring is not possible in any of the hospitals surveyed. Considerable variation in errors across hospitals is of great interest; for instance, the range of penicillin and gentamicin overdoses was 0%–100% and 1.9%–66.7%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Assessment of neonatal care in clinical training facilities in Kenya

et al. 2014

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ObjectiveAn audit of neonatal care services provided by clinical training centres was undertaken to identify areas requiring improvement as part of wider efforts to improve newborn survival in Kenya.DesignCross-sectional study using indicators based on prior work in Kenya. Statistical analyses were descriptive with adjustment for clustering of data.SettingNeonatal units of 22 public hospitals.PatientsNeonates aged <7 days.Main outcome measuresQuality of care was assessed in terms of availability of basic resources (principally equipment and drugs) and audit of case records for documentation of patient assessment and treatment at admission.ResultsAll hospitals had oxygen, 19/22 had resuscitation and phototherapy equipment, but some key resources were missing—for example kangaroo care was available in 14/22. Out of 1249 records, 56.9% (95% CI 36.2% to 77.6%) had a standard neonatal admission form. A median score of 0 out of 3 for symptoms of severe illness (IQR 0–3) and a median score of 6 out of 8 for signs of severe illness (IQR 4–7) were documented. Maternal HIV status was documented in 674/1249 (54%, 95% CI 41.9% to 66.1%) cases. Drug doses exceeded recommendations by >20% in prescriptions for penicillin (11.6%, 95% CI 3.4% to 32.8%) and gentamicin (18.5%, 95% CI 13.4% to 25%), respectively.ConclusionsBasic resources are generally available, but there are deficiencies in key areas. Poor documentation limits the use of routine data for quality improvement. Significant opportunities exist for improvement in service delivery and adherence to guidelines in hospitals providing professional training.

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Section: Discussionmentioning

confidence: 99%