Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin

Gentamicin and methicillin resistant Staphylococcus aureus in dublin hospitals: clinical and laboratory studies

“…GMRSA isolates of different phage types were sometimes found in a single lesion, or in different sites in a patient, as had also been reported previously (Wyatt et al, 1977). Phage typing became less helpful as an epidemiological tool as the outbreak progressed.…”

“…However, as a result of the emergence of neomycin resistance in S. aureus in association with the topical use of neomycin, Lacey (1975) predicted that gentamicin resistance would appear in S. aureus. This prediction became a reality in 1975 and 1976 with the appearance of S. aureus strains resistant to gentamicin and other aminoglycosides in single unrelated cases and in outbreaks of hospital infection in many centres (Soussy et al, 1975;Speller et al, 1976;Wyatt et al, 1977;Greenhood et al, 1979). A more serious development was the appearance of strains of S. aureus resistant to gentamicin and several other antibiotics including methicillin (Soussy et al, 1976;Shanson et al, 1976;Crossley et al, 1979;Price et al, 1980).…”

Transfer of gentamicin resistance between coagulase-negative and coagulase-positive staphylococci on skin

“…Nevertheless the observations may account for the frequency with which skin patients feature in accounts of the appearance of gentamicin resistant staphylococci in hospitals (Warren & Roberts, 1976;Bint et al 1977;Wyatt et al 1977). …”

“…In addition it could be transferred to three of four standard strains of S. aureus and from these to another wild S. aureus. Such natural transfer could explain the apparently explosive appearance of gentamicin resistance (Wyatt et al 1977).…”

Transfer of Gentamicin Resistance Between Cultures of Staphylococcus Aureus in Nutrient Broth, Serum and Urine

“…Although specific epidemics have been associated with bacteria of uniform properties, many distinct strains, as indicated by differences in phage-typing pattern and sensitivity to other antibiotics, have been concerned (Soussy et al, 1975a;Shanson, Kensit and Duke, 1976;Speller et al, 1976;Warren and Roberts, 1976;Bint et al, 1977;Wyatt et al, 1977;Lewis and Altemeier, 1978;Michel, Stessman, and Sacks, 1978;Naidoo and Noble, 1978;Buckwold et al, 1979;Faden et al, 1979;Greenhood et al, 1979).…”