Abstract:Tigecycline (TIG) toxicity is a threat to health because of the mortality risk attributed to its overdose. Large doses result in fatal cardiomyopathy and acute cardiotoxicity. Gentamicin (GEN) is an aminoglycoside antibacterial agent that affects kidney function, causing nephrotoxicity. Six groups of rats (n=5) were used. Control (DW), TIG 7 (TIG 7 mg/kg IP), TIG14 (TIG 14 mg/kg IP), gentamicin (GEN), TIG 7+ GEN, and TIG 14+ GEN groups. Cardiac catalase (CAT) activity, glutathione (GSH), and malondialdehyde (M… Show more
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