Gentamicin-free bone cement does not alter proteinuria after hip arthroplasty

Vinge, Ellen; Lidgren, Lars

doi:10.3109/17453679708996191

Cited by 3 publications

(7 citation statements)

References 6 publications

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“…The renal reaction found in the present study appears to involve an increased glomerular permeability and a partial tubular reabsorption inhibition. It is similar to that observed in patients undergoing THR or TKR with gentamicin-containing bone cement (13), or THR with gentamicin-free bone cement (14). It is unrelated to the prophylactic use of cloxacillin/flu-cloxacillin (13).…”

Section: Discussionsupporting

confidence: 67%

“…Apparently, anti-oxidant mechanisms in the blood protect tissues from oxidant damage (26). We found that 50% of our patients had CK values above the upper limit of normal on the second postoperative day, indicating that the surgical trauma and/ or ischemia in TKR causes a muscular damage comparable to that seen in THR (14). Modig et al (24) found increased serum CK levels after release of the tourniquet during TKR.…”

Section: Discussionmentioning

confidence: 52%

“…A transient postoperative renal impairment in patients undergoing THR has previously been reported (10)(11)(12)(13)(14). It has been suggested to be caused by the use of systemic isoxazolyl penicillins (15,16), but we found signs of postoperative glomerular and tubular affection in patients after THR as well as total knee replacement (TKR), regardless of the use of isoxazolyl penicillin (13).…”

mentioning

confidence: 53%

“…It has been suggested to be caused by the use of systemic isoxazolyl penicillins (15,16), but we found signs of postoperative glomerular and tubular affection in patients after THR as well as total knee replacement (TKR), regardless of the use of isoxazolyl penicillin (13). It also appears to be unrelated to the use of gentamicin in the bone cement (14).…”

mentioning

confidence: 98%

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Renal dysfunction after total knee replacement is not aggravated by bone cement

Lidgren¹,

Grubb

Vinge

1998

Acta Anaesthesiol Scand

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 52%

mentioning

confidence: 53%

mentioning

confidence: 98%

See 2 more Smart Citations

Renal dysfunction after total knee replacement is not aggravated by bone cement

Lidgren¹,

Grubb

Vinge

1998

Acta Anaesthesiol Scand

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“…Furthermore, it is known that patients undergoing hip and knee arthroplasty develop a transient globular and tubular dysfunction. However, systemic prophylaxis with cloxacillin and bone cement containing gentamycin has not been considered to be the cause of this, but rather the surgical trauma (Nergelius et al 1997a,b, 1998, Vinge et al 1997). …”

Section: Discussionmentioning

confidence: 99%

Inadequate timing of prophylactic antibiotics in orthopedic surgery. We can do better

Stefánsdóttir¹,

Robertsson²,

W‐Dahl³

et al. 2009

Acta Orthopaedica

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Background and purpose There are rising concerns about the frequency of infection after arthroplasty surgery. Prophylactic antibiotics are an important part of the preventive measures. As their effect is related to the timing of administration, it is important to follow how the routines with preoperative prophylactic antibiotics are working.Methods In 114 consecutive cases treated at our own university clinic in Lund during 2008, the time of administration of preoperative prophylactic antibiotic in relation to the start of surgery was recorded from a computerized operation report. In 291 other cases of primary total knee arthroplasty (TKA), randomly selected from the Swedish Knee Arthroplasty Register (SKAR), the type and dose of prophylactic antibiotic as well as the time of administration in relation to the inflation of a tourniquet and to the start of surgery was recorded from anesthetic records.Results 45% (95% CI: 36–54) of the patients operated in Lund and 57% (CI: 50–64) of the TKAs randomly selected from the SKAR received the preoperative antibiotic 15–45 min before the start of surgery. 53% (CI: 46–61) received antibiotics 15–45 min before inflation of a tourniquet.Interpretation The inadequate timing of prophylactic antibiotics indicates that the standards of strict antiseptic and aseptic routines in arthroplasty surgery are falling. The use of a simple checklist to ensure the surgical safety may be one way of reducing infections in arthroplasty surgery.

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Risk factors for renal dysfunction after total hip joint replacement; a retrospective cohort study

2015

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Background and purpose of the studyRenal injury and dysfunction are serious complications after major surgery, which may lead to increased morbidity and mortality. The objective of our study was to identify the possible risk factors for renal dysfunction after total hip joint replacement surgery.MethodsA retrospective study was conducted among 599 consecutive primary hip joint replacements performed between January 2011 and December 2013. According to the RIFLE criteria, increased postoperative serum creatinine was considered indicative of postoperative renal injury. The Welch two-sample test, chi-square test, and Fisher exact test were used for statistical analysis.ResultsEighty-one patients (13.8 %) had significant moderate or severe postoperative renal dysfunction in which 10 patients (1.7 %) acquired severe and permanent renal impairment.ConclusionWe identified advanced age, hypertension, general anesthesia, high ASA scores, low intra-operative systolic BP, and prophylactic dicloxacillin as significant risk factors. Low baseline systolic BP, low baseline diastolic blood pressure, and hip fracture diagnosis were independent risk factors for postoperative increase in serum creatinine. Smoking, diabetes mellitus, high BMI, gender, and duration of surgery were not identified as significant risk factors.

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Gentamicin-free bone cement does not alter proteinuria after hip arthroplasty

Cited by 3 publications

References 6 publications

Renal dysfunction after total knee replacement is not aggravated by bone cement

Renal dysfunction after total knee replacement is not aggravated by bone cement

Inadequate timing of prophylactic antibiotics in orthopedic surgery. We can do better

Risk factors for renal dysfunction after total hip joint replacement; a retrospective cohort study

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