Genotyping of RB1 status identifies two distinct subtypes in EGFR‐mutant lung cancers with SCLC transformation
Jie Huang,
Shi‐Ling Zhang,
Chao Zhang
et al.
Abstract:Dear Editor, In this study, we investigate the significant yet underexplored clinical and molecular heterogeneity in epidermal growth factor receptor (EGFR)-mutant lung cancers transformed into small cell lung cancer (SCLC). Our work addresses a crucial unmet need in understanding the molecular underpinnings of this transformation and introduces a novel predictive model for assessing the transformation hazards in high-risk patients.Up to 14% of EGFR-mutant non-SCLC (NSCLC) patients experience SCLC transformati… Show more
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