Genotyping of hepatitis B virus in Malaysia based on the nucleotide sequence of preS and S genes

Ong, Hooi Tin; Duraisamy, G; Peng, Ng Kee; Tan, Wen Siang; Seow, Heng Fong

doi:10.1016/j.micinf.2004.12.016

Cited by 12 publications

(12 citation statements)

References 38 publications

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“…Ninety-three patients (12%) were included (Table 1). All patients received 20 mg of prednisolone (14) daily following transplantation, rapidly tapered to 5 mg/day at week 6. Prophylaxis against cytomegalovirus was administered for a period of 3 months in seronegative patient receiving a seropositive graft.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Significant rate of hepatitis B reactivation following kidney transplantation in patients with resolved infection

Kanaan

Kabamba

Maréchal

et al. 2012

Journal of Clinical Virology

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Section: Patient Characteristicsmentioning

confidence: 99%

Significant rate of hepatitis B reactivation following kidney transplantation in patients with resolved infection

Kanaan

Kabamba

Maréchal

et al. 2012

Journal of Clinical Virology

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“…Also, single nucleotide mutations within the a determinant may lead to changes in HBV subtypes; however, this is not the case for genotypes. [43–47] Genotypes B and C are the most prevalent genotypes found in Asia; however, genotypes A and D are the most prevalent genotypes found in India. [1112] …”

Section: Hbv Genotypesmentioning

confidence: 99%

“…Genotype G (subtype adw2 ) is found in the United States and Europe. [4647] Indeed, a study conducted in Sweden concluded that the genotypes of HBV seen in patients at an outpatient clinic correlated more with the country of the patients’ nativity than their current residency in Sweden. [48]…”

Section: Hbv Subtypes and Subgenotypesmentioning

confidence: 99%

Hepatitis B virus S gene escape mutants

Purdy¹

2007

Asian J Transfus Sci

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Hepatitis B virus (HBV) can be classified into nine immunological subtypes or eight genotypes. The most prevalent genotypes in Asia are genotypes B and C. HBV is transmitted parenteraly and can produce either asymptomatic or symptomatic disease. Although the consequences of acute hepatitis B can be severe, serious sequelae are associated with chronic infections. HBV seroprevalence ranges from intermediate (2%-7%) to high (≥8%) levels in Asia. Several strategies for the control and prevention of HBV infection have been found to be efficacious. They include vaccination and the administration of HBIG, interferon-a and nucleoside/nucleotide analogues. However, these procedures also apply selective pressures on HBV in infected individuals leading to the generation and accumulation of mutations in the S gene. Most of these mutations occur in the major hydrophilic region (MHR) of the S gene. These mutations create public health concerns as they can be responsible for reactivation of hepatitis B and occult hepatitis B infection. The inability to detect occult infections means that these individuals may become blood donors. This suggests that new strategies for donor evaluation and selection may need to be developed to protect the blood supply.

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“…Genotype G (subtype adw2) is found in the United States and Europe. 12,27 Further observation of the clinical complications on the year of March 2014 to August 2017, we found that HCC developed in 2 patients positive with adrq + strains. Both of the patients infected with adw2 strains had died from the complication of HBV infection: one patient from HCC and another patient by LC.…”

Section: Discussionmentioning

confidence: 77%

Hepatitis B Virus Subtype Distribution in Bangladeshi Chronic Carriers

Tanzem¹,

Tabassum

Munshi

et al. 2018

Northern Int. Med. Coll. J.

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Background : Hepatitis B virus (HBV) infection is one of the major global health problems and this virus has many variants that differ from epidemiological distributions, transmission sources, clinical outcomes, diagnostic assays as well as therapeutic responses. HBV was also divided into 9 different subtypes which has distinct geographical distributions and important for the epidemiological studies and vaccine development.Objective : Bangladesh is an intermediate prevalence region for HBV infection, however, very little is known about the incidence of HBV subtypes in circulation. Therefore, we investigated the HBV subtype distribution in Bangladesh.Method : A small cohort was performed on between March 2014 and August 2017 with 172 HBV DNA positive patients from the BSMMU. From them, 29 HBV DNA samples were isolated for sequencing by Sanger method. HBsAg subtypes were determined by identifying of 226 amino acid (aa) positions in the small surface (S) gene.Result : Our study showed that HBV subtype adrq+ was in 17 (58.6%) isolates, ayw3 in 8 (27.5%), ayw2 in 2 (6.9%) and adw2 in 2 (6.9%) isolates.Conclusion : We conclude subtype adrq+ predominant in Bangladesh. This was followed by ayw3, while adw2 and ayw2 were least dominant. Subtype adw2 and adrq+ strains are found to be related with more complication, therefore, patients infected with these HBV strains need to be careful monitoring to assess their clinical outcome in future.Northern International Medical College Journal Vol.9(2) Jan 2018: 286-290

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Genotyping of hepatitis B virus in Malaysia based on the nucleotide sequence of preS and S genes

Cited by 12 publications

References 38 publications

Significant rate of hepatitis B reactivation following kidney transplantation in patients with resolved infection

Significant rate of hepatitis B reactivation following kidney transplantation in patients with resolved infection

Hepatitis B virus S gene escape mutants

Hepatitis B Virus Subtype Distribution in Bangladeshi Chronic Carriers

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