Genotyping of CARD15/NOD2, ATG16L1 and IL23R Genes in Polish Crohn’s Disease (CD) Patients – Are They Related to the Localization of the Disease and Extra-Intestinal Symptoms?

Relationship between the IL23R SNPs and Crohn’s Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study

“…Thus, we will re-evaluate this results in subsequent studies with larger sample size of individuals from Polish and Bosnian populations. Nevertheless, it is worth mentioning that genotype and allele frequencies of both investigated IL23R SNPs observed in our study are comparable to those reported in above mentioned studies from European-descent populations [22,32,33,34,35,36,37,38,39,40,41,42,43,44,45].…”

“…On the other hand, no association of rs1004819: A with CD was found by Doecke et al in the New Zealand cohort [33]. Additionally, no significant association of IL23R rs1004819 SNP was found in another Polish study by Jakubowska-Burek et al Interestingly, in their study, the heterozygous risk genotype rs1004819: G/A over-representation was observed in control group, while the rs1004819: A/A genotype frequency was higher in CD subjects [39]. Similar genotypes distribution, with higher frequency of the heterozygous risk genotype rs1004819: G/A in controls compared to CD patients and without significant association with CD, was also observed in our study, in the Bosnian population.…”

“…In the Polish study by Jakubowska-Burek et al a significantly higher frequency of genotypes containing rs75717847: T risk variant (T/T and T/G) was observed in CD subjects compared to controls. However, no significant differences were found in the proportion of genotypes containing protective IL23R rs75717847: G variant (T/T and T/G) [39].…”