Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally

Amedee, Angela M.; Lacour, Nedra; Gierman, Joshua L.; Martin, Louis N.; Clements, Janice E.; Bohm, Rudolf P.; Harrison, Richard M.; Murphey‐Corb, Michael

doi:10.1128/jvi.69.12.7982-7990.1995

Cited by 95 publications

(35 citation statements)

References 14 publications

(18 reference statements)

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“…The four chronically infected females had rapid disease courses, and all four macaques were euthanized due to disease progression within 8 months of inoculation. Few studies have evaluated SIV disease in pregnant and post-partum macaques, but in previous studies evaluating in utero transmission, rapid disease courses were frequently seen in macaques inoculated during gestation [1].…”

Section: Discussionmentioning

confidence: 99%

“…In the chronic infection model, female monkeys were timed-mated using exogenous progesterone administration and withdrawal as described previously, and fetal growth was monitored by ultrasound examination [1]. Females were inoculated intravenously during mid-gestation (day 90 of a 165 day gestation period) with the same SIV/DeltaB670 stock as described above.…”

Section: Animalsmentioning

confidence: 99%

“…PCR products were pooled and cloned into the TOPO TA vector (Invitrogen, Carlsbad, CA, USA). Plasmids containing appropriately sized inserts were selected for sequence analysis as described previously [1]. Sequences were aligned and compared with MacVector (Accelrys Inc., Madison, WI, USA).…”

Section: Viral Envelope Sequencesmentioning

confidence: 99%

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Mother‐to‐infant transmission of SIV via breast‐feeding in rhesus macaques

Amedee¹,

Lacour²,

Ratterree³

2003

J of Medical Primatology

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To decipher the mechanisms involved in oral transmission of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) through breast-feeding, we have developed an animal model using SIV-infected lactating rhesus macaques (Macaca mulatta) and their infants. Five of eight macaque infants became infected during a 10-month study course after SIV inoculation of lactating dams. In a second study, three of four chronically infected female macaques transmitted virus to their infants through breast-feeding within 4 months of birth. Transmission of virus to infants did not correlate with viral loads in either milk or plasma. Infants were infected with homogeneous virus populations, while milk samples near the time of transmission were more diverse. These studies suggest that specific viral phenotypes are selectively transmitted through breast-feeding.

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Section: Discussionmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

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Mother‐to‐infant transmission of SIV via breast‐feeding in rhesus macaques

Amedee¹,

Lacour²,

Ratterree³

2003

J of Medical Primatology

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“…The restriction mechanism of viral secretion from the blood to the vaginal cavity is unknown. In the human cases of perinatal transmission, the viral genotypes found in infants were reported to be single genotypes from the maternal quasispecies (3,28). It is possible that viral selection from the infected mother to the infant might occur during delivery through vaginal secretions, resulting in a single genotype.…”

Section: Discussionmentioning

confidence: 99%

Genomic Analysis of the Viral Population in Genital Secretions Early after Infection of Simian Immunodeficiency Viruses in Macaque Monkeys

Enose

Ibuki

Shimada

et al. 1998

Microbiology and Immunology

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To clarify the change in the viral population during passage from the vaginal cavity to blood circulation and vice versa, we examined the viral clones detected in cells in vaginal washes (VWCs) early after inoculation and after systemic infection with polyclonal SIV. In two intravaginally inoculated monkeys, the viral clones found in VWCs at 18 days p.i. were shown to be some of those contained in the inoculum, whereas the viral population in the peripheral blood mononuclear cells (PBMCs) was a monotype. This gradual decrease of viral clones suggested the possible existence of two barriers, one at the genital tract and the other between the genital tract and the blood. Later, at one month p.i., the viral clones in VWCs became rather restricted, whereas those in PBMCs diverged from a single clone to several clones. This suggested that different mechanisms affect the viral populations in PBMCs and VWCs. In order to examine how the viral population was affected by passage from the blood to the vaginal cavity, a monkey was intravenously inoculated and the viral clones in VWCs were analyzed at 14 days p.i., at a time of the heterogeneous population in PBMCs. The viral population in VWCs was found to be a single clone and this clone was a minor type in PBMCs, suggesting that the major clone in PBMCs was not always secreted to the vaginal cavity.

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“…Vaginal ) ) ) nd ) ) ) ) nd nd, not done. 1 Mode of delivery mentioned to exclude certain modes of transmission. 2 Insufficient cells to perform DNA viral load in PBMCs.…”

Section: Viral Loads Antibody Responses and Transmission To Infantsmentioning

confidence: 99%

Perinatal transmission of SHIV‐SF162P3 in Macaca nemestrina

Jayaraman

Mohan

Polacino

et al. 2004

J of Medical Primatology

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We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten pregnant dams were infected intravenously with 100 MID(50) of macaque-titered SHIV-SF162P3 during the second trimester. Nine infants were born; the seven surviving beyond day of birth suckled for 6 months. Four of nine infants were infected (transmission rate = 44.4%), with one infection in utero, and three intrapartum and/or immediately post-birth via suckling. Varying levels of binding and neutralizing antibodies were transplacentally transferred to infants. Passive antibodies were detected in plasma on the day of birth and persisted for 5 weeks. Infants infected at or after birth controlled acute and post-acute viremia. Exposure to maternal SHIV-SF162P3 during birth and suckling in the presence of autologous maternal neutralizing antibodies may have affected transmission or pathogenesis in the infants. This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV.

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Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally

Cited by 95 publications

References 14 publications

Mother‐to‐infant transmission of SIV via breast‐feeding in rhesus macaques

Mother‐to‐infant transmission of SIV via breast‐feeding in rhesus macaques

Genomic Analysis of the Viral Population in Genital Secretions Early after Infection of Simian Immunodeficiency Viruses in Macaque Monkeys

Perinatal transmission of SHIV‐SF162P3 in Macaca nemestrina

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