Genotypic female Atlantic salmon (Salmo salar) immersed in an exogenous androgen overexpress testicular-related genes and develop as phenotypic males

Brown, Morgan S.; Evans, Brad S.; Afonso, Luis O.B.

doi:10.1016/j.aquaculture.2021.737216

Cited by 2 publications

(2 citation statements)

References 76 publications

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“…Although Mn-SG declined, it remained at a certain level. Salmon ( O. kisutch ) larvae retain approximately 10% of exogenous steroids 16 days after cessation of treatment [ 44 ]. Most rats with a testis removed maintained spermatogenesis in numbers after receiving exogenous hormone treatment.…”

Section: Discussionmentioning

confidence: 99%

Sex Reversal Induced by Dietary Supplementation with 17α-Methyltestosterone during the Critical Period of Sex Differentiation in Oriental River Prawn (Macrobrachium nipponense)

Cai

Yuan

Gao

et al. 2023

Animals

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The steroid 17α-methyltestosterone (MT) inhibits ovarian function and is often used to induce sex reversal artificially in vertebrates. In the present study, different concentrations of MT were added as dietary supplementation, and the effects on sex ratio, growth, and gonadal development were examined. After 40 days, the sex ratio (male:female) in each group increased at different degrees with 50 (1.36:1), 100 (1.57:1), and 200 (2.61:1) mg/kg MT, and neo-males with testis–ovary coexistence were observed in the 200 mg/kg MT group. Furthermore, 50 and 100 mg/kg MT could induce female reversion in neo-males. Histologically, the development of the testes in experimental groups was slower, but the ovaries of the experimental and control groups had similar developmental rates. The expression levels of DMRT11E, Foxl2, and SoxE1 in males at 200 mg/kg MT were 8.65-, 3.75-, and 3.45-fold greater than those of the control group. In crustaceans, sex reversal through vertebrate sex hormones can be observed. Neo-males (sex-reversed female prawns) were maintained by exogenous androgen, and over-reliance led to slow testis growth, small body size, and low growth rate, but sperm was still produced. In female prawns, MT inhibited ovary development and promoted growth.

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Section: Discussionmentioning

confidence: 99%

Sex Reversal Induced by Dietary Supplementation with 17α-Methyltestosterone during the Critical Period of Sex Differentiation in Oriental River Prawn (Macrobrachium nipponense)

Cai

Yuan

Gao

et al. 2023

Animals

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“…Several studies using steroid immersion techniques have identified androgens and oestrogens as critical drivers of sexual differentiation in teleost fishes. Immersing larval teleosts in androgens or oestrogens can lead to anywhere from approximately 75% to 100% male and female fish, respectively [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. In addition, pharmacological inhibition of aromatase by immersion also leads to a majority male offspring in teleosts [23,29,32,[36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Androgen receptor alpha deficiency impacts aromatase expression in the female cichlid brain

Lopez,

Alward

2024

R. Soc. Open Sci.

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Steroid hormones bind to specific receptors that act as transcription factors to modify gene expression in the brain to regulate physiological and behavioural processes. The specific genes controlled by steroid hormones in the brain are not fully known. Identifying these genes is integral to establishing a comprehensive understanding of how hormones impact physiology and behaviour. A popular organism for answering this question is the cichlid fish Astatotilapia burtoni . Recently, CRISPR/Cas9 was used to engineer A. burtoni that lack functional androgen receptor (AR) genes encoding ARα. ARα mutant male A. burtoni produced fewer aggressive displays and possessed reduced expression of the gene encoding brain-specific aromatase, cyp19a1 , in the ventromedial hypothalamus (VMH), an aggression locus. As a follow-up, we investigated whether ARα deficiency affected cyp19a1 expression in female A. burtoni using the same genetic line. We find that female A. burtoni possessing one or two non-functional ARα alleles had much higher expression of cyp19a1 in the preoptic area (POA), while females with one non-functional ARα allele possessed lower expression of cyp19a1 in the putative fish homologue of the bed nucleus of the stria terminalis (BNST). Thus, ARα may have a sex-specific role in modifying cyp19a1 expression in the teleost POA and BNST, regions that underlie sex differences across vertebrates.

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Genotypic female Atlantic salmon (Salmo salar) immersed in an exogenous androgen overexpress testicular-related genes and develop as phenotypic males

Cited by 2 publications

References 76 publications

Sex Reversal Induced by Dietary Supplementation with 17α-Methyltestosterone during the Critical Period of Sex Differentiation in Oriental River Prawn (Macrobrachium nipponense)

Sex Reversal Induced by Dietary Supplementation with 17α-Methyltestosterone during the Critical Period of Sex Differentiation in Oriental River Prawn (Macrobrachium nipponense)

Androgen receptor alpha deficiency impacts aromatase expression in the female cichlid brain

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