Genotypic diversity of Streptococcus suis strains isolated from humans in Thailand

Kerdsin, Anusak; Akeda, Yukihiro; Takeuchi, Dan; Dejsirilert, Surang; Gottschalk, Marcelo; Oishi, Kazunori

doi:10.1007/s10096-018-3208-8

Cited by 42 publications

(69 citation statements)

References 32 publications

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“…Currently, 29 serotypes of S. suis are recognized [4]. Of these, serotype 2 is the most prevalent in S. suis human infections, although cases have also been reported caused by serotypes 4,5,9,14,16,21,24, and 31 [1][2][3][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

et al. 2020

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Streptococcus suis is a zoonotic pathogen of economic significance to the swine industry. The number of infected cases is increasing in humans worldwide. In this study, we determined the prevalence and diversity of S. suis carriage in slaughterhouse pigs in Phayao province, Thailand, where an outbreak occurred in 2007. The overall S. suis carriage rate was 35.2% among slaughterhouse pigs. The prevalence rates of serotypes 2 and 14 (the major serotypes infected in humans) were 6.7% and 2.6%, respectively. In both serotypes, 70.4% of isolates of serotypes 2 and 14 revealed sequence types and pulsotypes identical to human isolates in Thailand. It is suggested that pathogenic strains of S. suis are a risk factor for occupational exposure to pigs or the consumption of raw pork products. Food safety, hygiene, and health education should be encouraged to reduce the risk group.

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Section: Introductionmentioning

confidence: 99%

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

et al. 2020

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“…Since S. suis was first discovered, approximately 1,600 S. suis-infected cases have been reported in humans worldwide (5). In addition to two large-scale outbreaks of S. suis in China, the pathogen (S. suis serotype 2 [SS2]) is considered the primary cause of adult meningitis in Vietnam, the second in Thailand, and the third in Hong Kong (2,6). The survivors of S. suis-induced meningitis often suffer from irreversible sequelae such as deafness (7).…”

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confidence: 99%

Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

Shen

Niu

et al. 2018

Appl Environ Microbiol

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Streptococcus suis, an important zoonotic pathogen, has caused considerable economic losses in the swine industry and severe public health issues worldwide. The development of a novel effective strategy for the prevention and therapy of S. suis is urgently needed. Here, amentoflavone, a natural biflavonoid compound isolated from Chinese herbs that has negligible anti-S. suis activity, was identified as a potent antagonist of suilysin (SLY)-mediated hemolysis without interfering with the expression of SLY. Amentoflavone effectively inhibited SLY oligomerization, which is critical for its pore-forming activity. The treatment with amentoflavone reduced S. suis-induced cytotoxicity in macrophages (J774 cells). Furthermore, S. suis-infected mice that received amentoflavone exhibited lower mortality and bacterial burden. Additionally, amentoflavone significantly decreased the production of tumor necrosis factor alpha (TNF-␣), interleukin-1␤ (IL-1␤), and IL-6 in an S. suis-infected cell model. Analyses of signaling pathways demonstrated that amentoflavone reduced S. suisinduced inflammation in S. suis serotype 2 (SS2)-infected cells by regulating the p38, Jun N-terminal protein kinase 1 and 2 (JNK1/2), and NF-B pathways. The antivirulence and anti-inflammatory properties of amentoflavone against S. suis infection provide the possibility for future pharmaceutical application of amentoflavone in the treatment of S. suis infection. IMPORTANCEThe widespread use of antibiotics in therapy and in the prevention of Streptococcus suis infection in the swine industry raises concerns for the emergence of a resistant strain. The use of antivirulence agents has potential benefits, mainly because of the reduced selective pressure for the development of bacterial resistance. In this study, we found that amentoflavone is an effective agent against S. suis serotype 2 (SS2) infection both in vitro and in vivo. Our results demonstrated that amentoflavone is a promising anti-infective therapeutic for S. suis infections, due to its antivirulence and anti-inflammatory effects without antibacterial activity, with fewer side effects than conventional antibacterial agents.

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“…The unavailability of S. suis serotyping at the hospital made it impossible to gather the genotypic profile, yet it could be assumed that most infections should be from serotype 2 based on the previous genotyping study. 37,38 In addition, the selection of only positive hemoculture or CSF cases may have led to us missing some clinical presentations such as ecchymosis, petechiae and other skin abnormalities. However, we believe that this selection bias would indicate positive cases from true infection.…”

Section: Others 16%mentioning

confidence: 99%

<p>Clinical Manifestations and Risk Factors of <em>Streptococcus suis</em> Mortality Among Northern Thai Population: Retrospective 13-Year Cohort Study</p>

Rayanakorn¹,

Katip²,

Goh³

et al. 2019

IDR

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Purpose: Streptococcus suis (S. suis) is an emerging zoonotic disease mainly in pigs, causing serious infections in humans with high prevalence in Southeast Asia. Despite a relatively high mortality rate, there are limited data regarding the risk factors of this lifethreatening infection. Therefore, a 13-year retrospective cohort study in Chiang Mai, Thailand during 2005-2018 was conducted to explore risk factors associated with S. suis mortality and to update the outcomes of the disease. Patients and methods: S. suis positive cases were derived from those with positive S. suis isolates from microbiological culture results and Matrix-Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF). Potential risk factors of mortality were identified using univariate and multivariate logistic regression. Results: Of 133 patients with culture-proven S. suis infection identified, there were 92 males and 41 females. The mean age was 56.47 years. Septicemia (55.64%) was the most common clinical manifestation followed by meningitis (37.59%) and infective endocarditis (25.56%). Alcohol drinking and raw pork consumption were documented in 66 (49.62%) and 49 (36.84%) cases respectively. The overall mortality rate was 12.03% (n=16). According to the multivariate analysis, the independent risk factors for mortality were prolonged bacteremia ≥ 6 days (OR = 43.57, 95% CI = 2.46-772.80, P =0.010), septic shock (OR = 13.34, 95% CI = 1.63-109.03, P =0.016), and direct bilirubin > 1.5 mg/dL (OR = 12.86, 95% CI = 1.91-86.59, P =0.009). Conclusion: S. suis is not infrequent in Northern Thailand, where the cultural food habit of raw pork eating is still practiced. To the best of our knowledge, this is the largest series focusing on risk factors of S. suis mortality which has been conducted in Thailand. Prolonged bacteremia ≥ 6 days, septic shock, and direct bilirubin > 1.5 mg/dL were strong predictors associated with S. suis mortality. The mortality risk factors identified may be further utilized in clinical practice and future research to improve patient outcomes.

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Genotypic diversity of Streptococcus suis strains isolated from humans in Thailand

Cited by 42 publications

References 32 publications

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

<p>Clinical Manifestations and Risk Factors of <em>Streptococcus suis</em> Mortality Among Northern Thai Population: Retrospective 13-Year Cohort Study</p>

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