Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013–2015

Zhao, Yanjie; Shen, Jun; Wu, Bingjie; Liu, Gaoshan; Lu, Roujian; Tan, Wenjie

doi:10.3389/fmicb.2018.01836

Cited by 38 publications

(52 citation statements)

References 30 publications

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“…In Shanghai, China, HRV A (14.0%) was the predominant species, followed by HRV C (5.6%), then HRV B (2.1%) in SARIs, too. However, their results showed no significant difference in clinical symptoms according to HRV species (14). In the study, when gender, age and co-infection were all considered and using HRV C as the control species, HRV A was a dangerous factor to cause severe clinical outcome (OR=1.983>1 ,95% CI=1.091-3.605, the lower limit of 95% CI>1) (p=0.025), and HRV B has no relationship with severity of clinical outcome.…”

Section: Discussionmentioning

confidence: 89%

“…It has been shown in a number of studies that HRV A and HRV C were associated with more severe outcome in the pediatric population (7)(8)(9)(10)(11)(12). Other results supported that HRV C, which may be one of the key factors in the association of HRVs with asthma (13), may cause more severe illness, and is more frequently associated with wheezing episodes, asthma exacerbations, and lower respiratory tract infections than HRV A and HRV B (8,(14)(15)(16).…”

Section: Introductionmentioning

confidence: 92%

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Diversity of human rhinovirus species among children with severe or mild acute lower respiratory infection in Beijing, China, during 2016–2019

Chen

Zhang

Yuan

et al. 2019

Preprint

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Background Human rhinovirus (HRV) infections were confirmed in severe acute lower respiratory infections (ALRI) . Methods To evaluate the diversity and circulation pattern of HRVs species, specimens were collected from pediatric patients with ALRI during Dec 2016 to Feb 2019 and screened by RVP FAST Assay. Specimens positive for HRVs/ Enteroviruses (EVs) were then tested for HRVs and EVs by PCR. Then the capsid protein gene of HRVs was amplified and sequenced for species identification, and clinical data of HRV infections were analyzed. The chi-square (χ 2 ) test and rank sum test was used for statistical analysis using SPSS Statistics 22.0 version. In order to test and evaluate the relationship between patients positive for different HRV species and the outcome of Intensive Care Unit (ICU) (ICU group) or Department of Respiratory admission (Respiratory group), a logistic model was constructed using multiple logistic regression analysis. Results Among 1835 specimens tested, 363 (19.8%) were positive for EVs/HRVs, and 314 (86.5%, 314/363) were positive for HRVs, including 177 (56.4%, 177/314) HRV A, 29 (9.2%, 29/314) HRV B, and 108 (34.4%, 108/314) HRV C. Using HRV C as the control species, HRV A was a dangerous factor for severe clinical outcome (OR=1.983, 95% CI=1.091-3.605) ( p =0.025). Patients positive for HRVs from ICU group were significantly younger than those from Respiratory group (0.39 years: 1.80 years, p =0.000) and age was confirmed as a protective factor for severe ALRI. In August and September, HRV A and B are the dominant species, then HRV C in October and December. Among 96 types confirmed in the study, the predominant types usually showed in no consecutive years. Conclusions HRVs were important viral pathogens for ALRI in children. HRV A and C are more popular. Compared to HRV C, HRV A were associated more powerful with severe ALRI. The risk of severe ALRI by HRVs infections is decreased with the increasing of age.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 92%

Diversity of human rhinovirus species among children with severe or mild acute lower respiratory infection in Beijing, China, during 2016–2019

Chen

Zhang

Yuan

et al. 2019

Preprint

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“…The majority of studies conducted in many parts of the world have consistently reported that RV-A, B, and C are detected in 48% to 65%, 2% to 12%, and 26% to 44% of samples, respectively. 4,5,7,9,12,[14][15][16][17][18][19]26,27,30,[32][33][34][35] Our study is unique to many other studies in that we assessed viral types in a communitybased rural setting, using prospective surveillance, compared with the clinic or hospital-based surveillance in more urban settings.…”

Section: Illness Severitymentioning

confidence: 99%

“…37 No associations between RV species and illness severity have been reported by others. 4,[14][15][16]18,19,30,38 However, some studies have shown that RV-C species are more likely to cause LRT illnesses than RV-A 5,9 including specific clinical findings, such as wheezing, 12,39 asthma, 31 rhonchi, vomiting, 13 and viremia. 26 The discrepancies between these studies may be due to the patients that were tested.…”

Section: Illness Severitymentioning

confidence: 99%

“…However, no differences in illness severity between RV species were found in other studies. [14][15][16][17][18][19] The epidemiology and clinical significance of specific RV types have not been analyzed for very young infants in a rural community setting. The molecular characterization of RV infections is limited for RV circulating in developing countries, including countries in Asia, such as Nepal.…”

Section: Introductionmentioning

confidence: 99%

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Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal

Kuypers

Perchetti

Chu

et al. 2019

Journal of Medical Virology

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Problem Rhinoviruses (RVs), the most common causes of acute respiratory infections in young children and infants, are highly diverse genetically. Objective To characterize the RV types detected with respiratory illness episodes in infants in Nepal. Study methods Infants born to women enrolled in a randomized trial of maternal influenza immunization in rural, southern Nepal were followed with household‐based weekly surveillance until 180 days of age. Infants with respiratory symptoms had nasal swabs tested for twelve respiratory viruses. A subset with RV alone was selected for sequencing of the VP4/2 gene to identify RV types. Results Among 547 RV‐only positive illnesses detected from December 2012 to April 2014, 285 samples (52%) were sequenced. RV‐A, B, and C species were detected in 193 (68%), 18 (6%), and 74 (26%) specimens, respectively. A total of 94 unique types were identified from the sequenced samples, including 52 RV‐A, 11 RV‐B, and 31 RV‐C. Multiple species and types circulated simultaneously throughout the study period. No seasonality was observed. The median ages at illness onset were 88, 104, and 88 days for RV‐A, B, and C, respectively. The median polymerase chain reaction cycle threshold values did not differ between RV species. No differences between RV species were observed for reported respiratory symptoms, including pneumonia, or for medical care‐seeking. Conclusions Among very young, symptomatic infants in rural Nepal, all three species and many types of RV were identified; RV‐A was detected most frequently. There was no association between RV species and disease severity.

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Clinical characteristics, outcomes, and seasonality of acute respiratory infection associated with single and codetected rhinovirus species among hospitalized children in Amman, Jordan

Talj¹,

Amarin²,

Rankin

et al. 2022

Journal of Medical Virology

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Rhinovirus (RV)-specific surveillance studies in the Middle East are limited.Therefore, we aimed to study the clinical characteristics, outcomes, and seasonality of RV-associated acute respiratory infection among hospitalized young children in Jordan. We conducted a prospective viral surveillance study and enrolled children <2 years old admitted to a large public hospital in Amman, Jordan (2010)(2011)(2012)(2013).Demographic and clinical data were collected by structured interviews and chart abstractions. Nasal and/or throat swabs were collected and tested for a panel of respiratory viruses, and RV genotyping and speciation was performed. At least one virus was detected in 2641/3168 children (83.4%). RV was the second most common virus detected (n = 1238; 46.9%) and was codetected with another respiratory virus in 730 cases (59.0%). Children with RV codetection were more likely than those with RV-only detection to have respiratory distress but had similar outcomes. RV-A accounted for about half of RV-positive cases (54.7%), while children with RV-C had a higher frequency of wheezing and reactive airway disease.RV was detected year-round and peaked during winter. In conclusion, though children with RV codetection had worse clinical findings, neither codetection nor species affected most clinical outcomes.

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Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013–2015

Cited by 38 publications

References 30 publications

Diversity of human rhinovirus species among children with severe or mild acute lower respiratory infection in Beijing, China, during 2016–2019

Diversity of human rhinovirus species among children with severe or mild acute lower respiratory infection in Beijing, China, during 2016–2019

Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal

Clinical characteristics, outcomes, and seasonality of acute respiratory infection associated with single and codetected rhinovirus species among hospitalized children in Amman, Jordan

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