Genotypic characterization of macrolide-resistant strains of Streptococcus pneumoniae isolated in Quebec, Canada, and in vitro activity of ABT-773 and telithromycin

Weiss, Karl Heinz; Guilbault, Claudine; Cortés, Leonardo Bonilla; Restieri, C.; Low, Donald E.

doi:10.1093/jac/dkf146

Cited by 29 publications

(21 citation statements)

References 12 publications

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“…To our knowledge, the current study represents the youngest age group in which this phenomenon has ever been described. Increased E. coli [43][44][45][46] and Streptococcus pneumoniae 9,[47][48][49] resistance in younger children generally have been attributed to greater antibiotics use by these children, [43][44][45][46][47] although one study cautioned that this could not be true for quinolone resistance because this drug was not used in their youngest age group. 46 Many investigators lacked data on their subjects' antibiotics use, and only two 9, 45 examined use and age together in a multivariable analysis.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

Kalter¹,

Gilman²,

Moulton³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. Few studies have examined the influence of individual-, household-, and community-scale risk factors on carriage of resistant commensal bacteria. We determined children's medical, agricultural, and environmental exposures by household, pharmacy, and health facility surveys and Escherichia coli cultures of children, mothers' hands, household animals, and market chickens in Peru. Among 522 children with a positive stool culture, by log-binomial regression, using "any antibiotic" and 1-14 (versus 0) sulfa doses in the past 3 months increased children's risk, respectively, for ampicillin-and sulfamethoxazole-resistant E. coli carriage ( P = 0.01-0.02). Each household member taking "any antibiotic" increased children's risk for sulfamethoxazole-and multidrug-resistant E. coli carriage ( P < 0.0001). Residence in a zone where a larger proportion of households served home-raised chicken (as contrasted with intensively antibiotic-raised market chicken) protected against carrying E. coli resistant to all drugs ( P = 0.0004-0.04). Environmental contamination with drug-resistant bacteria appeared to significantly contribute to children's carriage of antibiotic-resistant E. coli .

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

Kalter¹,

Gilman²,

Moulton³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…The Canadian Bacterial Surveillance Network also reported higher rates of penicillin NS for nonsterile compared with sterile isolates (16.6% versus 12.4%, P=0.005), with LRT specimens constituting 60% of the nonsterile isolates (14). Similarly, in Quebec, noninvasive isolates demonstrated higher rates of resistance to macrolides, penicillin and cephalosporins (39). The Tracking Resistance in the United States Today (TRUST) program in the United States reported higher rates of resistance among LRT isolates versus blood for penicillin, azithromycin, TMP-SMX and levofloxacin (P<0.0001 for all comparisons) (12).…”

Section: Tmp/smx Ns Isolates (N=426)mentioning

confidence: 96%

Antimicrobial Susceptibility of Invasive and Lower Respiratory Tract Isolates of Streptococcus pneumoniae, 1998 to 2007

Vanderkooi

McConnell

Church

et al. 2009

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Previous surveys of antimicrobial resistance inStreptococcus pneumoniaehave found differences depending on source of isolate (eg, higher resistance in lower respiratory tract [LRT] versus invasive isolate) and age (higher resistance in children versus adults). Susceptibility profiles in the Calgary Health Region (approximately 1.25 million population) over a 10-year period were studied. Prospective laboratory-based population surveillance forS pneumoniaedisease has been conducted since 1998. Patient demographics and susceptibility testing were analyzed. In total, 2382 patient isolates were available for analysis from 1998 to 2007. Of these, 1170 isolates were invasive while 496 were LRT. Patient age distribution was: younger than five years, 14%; five to 17 years, 6%; 18 to 64 years, 56%; and 65 years or older, 24%. Mean patient age was 44.8 years and 60.0% were male. The overall incidence of nonsusceptibility was: penicillin, 8.2%; amoxicillin, 0.3%; cefuroxime, 6.2%; ceftriaxone, 1.7%; erythromycin, 8.8%; trimethoprim-sulfamethoxazole (TMP-SMX), 25.6%; clindamycin, 2.3%; and levofloxacin, 0.2%. Overall resistance rates were stable, except for increasing erythromycin resistance from 5.4% (1998) to a high of 14.2% (2004) (P=0.007). Isolates that were nonsusceptible to penicillin or TMP-SMX were more likely to be multidrug resistant (P<0.001) compared with penicillin- or TMP-SMX-susceptible isolates. Compared with invasive isolates, LRT isolates showed more resistance to penicillin, TMP-SMX, cefuroxime and erythromycin, and were more likely to be multidrug resistant. Isolates from children younger than five years of age are more likely to be multidrug resistant and resistant to erythromycin and cefotaxime. Ongoing surveillance ofS pneumoniaeisolates is important because resistance rates vary by source and patient age among health care regions.

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“…In these cases, however, the ketolide generally retains the activity (Tait-Kamradt et al, 2000;Jalava et al, 2001;Malbruny et al, 2002;Morosini et al, 2003;Reinert et al, 2003). Resistance to ketolide was observed for some portion of bacteria carrying the erm(B) gene (Singh et al, 2001;Nagai et al, 2002;Weiss et al, 2002;Morosini et al, 2003;Reinert et al, 2003), which implies that a certain variant of erm(B) is responsible for the resistance to ketolide. Several mutations or deletions were previously found in the regulatory region of erm(B) from laboratory-derived mutants of Streptococcus pneumoniae and clinical isolates of S. pneumoniae with decreased susceptibility or resistance to telithromycin (Walsh et al, 2003;Hisanaga et al, 2005;Wolter et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Alterations in regulatory regions of erm(B) genes from clinical isolates of enterococci resistant to telithromycin

et al. 2011

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We determined rates of resistance to the ketolide telithromycin in 56 Enterococcus faecalis isolates and 44 Enterococcus faecium isolates collected from hospitals in Korea between 2005 and 2006. Twenty nine (51.8%) isolates of E. faecalis and 35 (79.5%) isolates of E. faecium were resistant to telithromycin (minimum inhibitory concentrations, ≥ 4 μg/mL). All of the telithromycin-resistant E. faecalis carried the erm(B) gene only. Of the telithromycin-resistant E. faecium, 29 resistant strains carried erm(B) only, the other six carried erm(A) and erm(B) together. The nucleotide sequence of the erm(B) regulatory regions from 29 E. faecalis and 29 E. faecium isolates with erm(B) only was analyzed. Five types of alterations were detected. The first and second types had point mutations that destabilize the secondary structure of erm(B) mRNA sequestering the translation initiation region of the structural gene. The third type was identical to erm(Bv1), a previously reported variant of erm(B) with different induction specificity. The fourth and fifth types had point mutations within the critical sequence for induction and a point mutation destabilizing the stem-loop of erm(B) mRNA sequestering the translation initiation region of the structural gene.

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Genotypic characterization of macrolide-resistant strains of Streptococcus pneumoniae isolated in Quebec, Canada, and in vitro activity of ABT-773 and telithromycin

Cited by 29 publications

References 12 publications

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

Antimicrobial Susceptibility of Invasive and Lower Respiratory Tract Isolates of Streptococcus pneumoniae, 1998 to 2007

Alterations in regulatory regions of erm(B) genes from clinical isolates of enterococci resistant to telithromycin

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