Genotypic Characterization of Human Immunodeficiency Virus Type 1 Isolated from Antiretroviral Treatment-Experienced Individuals in Buleleng Regency, Bali, Indonesia

Megasari, Ni Luh Ayu; Oktafiani, Devi; Ana, Elsa Fitri; Ueda, Shuhei; Kotaki, Tomohiro; Nasronudin, -; Soetjipto,; Kameoka, Masanori

doi:10.1089/aid.2019.0058

Cited by 2 publications

(5 citation statements)

References 10 publications

(8 reference statements)

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“…Subtyping results were consistent with previous studies. [4][5][6][7][8][9] The CRF01_AE was found to be a predominant CRF among HIV-infected treatmentnaive individuals in Jakarta. The CRF is known to predominantly circulate in Southeast-Asian countries, including Thailand and Malaysia, 18,19 as well as in East-Asian countries, including Taiwan, China, South Korea, and Japan.…”

Section: Discussionmentioning

confidence: 93%

“…These results suggest that CRF01_AE was the predominant CRF in Jakarta, similar to other regions in Indonesia. [4][5][6][7][8][9]…”

Section: Hiv-1 Subtypingmentioning

confidence: 99%

“…1 As many other countries, HIV infection in Indonesia is mainly caused by HIV type 1 (HIV-1) group M. There are nine subtypes (A, B, C, D, F, G, H, J, and K), as well as circulating recombinant forms (CRFs) and unique recombinant forms (URFs), within the group M. 3 Several studies have reported the dominance of HIV-1 CRF01_AE in several Indonesian regions. [4][5][6][7][8][9][10] As an effort to address the HIV epidemic, Ministry of Health of Indonesia implemented antiretroviral therapy (ART) under national guideline. First-line ART regimen recommended contains two nucleoside reverse transcriptase (RT) inhibitors (NRTIs) and one non-nucleoside RT inhibitor (NNRTI).…”

Section: Introductionmentioning

confidence: 99%

“…12 The emergence of acquired drug resistance (ADR) in treatment-experienced individuals and transmitted drug resistance (TDR) in treatment-naive individuals residing in several Indonesian regions, including Surabaya, Riau, Bali, and Maumere, has been previously described. [5][6][7][8][9][10] The TDR might disrupt effectiveness of treatment, resulting in unfavorable clinical outcomes. 13 Therefore, it is important to monitor the emergence of TDR by a continuous surveillance in order to secure long-term and stable ART in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Detection of Human Immunodeficiency Virus Type 1 Transmitted Drug Resistance among Treatment-Naive Individuals Residing in Jakarta, Indonesia

Khairunisa

Megasari

Rahayu

et al. 2020

Infectious Disease Reports

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The presence of transmitted drug resist- ance (TDR) in human immunodeficiency virus type 1 (HIV-1) infected individuals naive to antiretroviral therapy, may affect the effectiveness of treatment. Jakarta, the capital city of Indonesia, recorded the high- est number of cumulative HIV infection cases in the country. This study aimed to identify on the appearance of TDR, as well as to identify HIV-1 subtypes circulating among treatment-naive individuals in Jakarta. Whole blood samples collected from 43 HIV-1 infected, treatment-naive individuals. Viral subtyping and drug resist- ance testing were performed on HIV-1 pol genes amplified using nested polymerase chain reaction. CRF01_AE was detected most frequently in Jakarta (73.08%). Drug resistance-related major mutation was not detected in protease fragments of pol gene, but two major mutations, K103N (6.67%) and Y181C (6.67%), were detected in reverse transcriptase fragments of pol gene. Our results suggest that TDR was emerged in Jakarta at a certain extent, thus further surveillance study to monitor the TDR prevalence and circulating HIV-1 subtypes in this region is considered to be necessary.

show abstract

Section: Discussionmentioning

confidence: 93%

“…These results suggest that CRF01_AE was the predominant CRF in Jakarta, similar to other regions in Indonesia. [4][5][6][7][8][9]…”

Section: Hiv-1 Subtypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Detection of Human Immunodeficiency Virus Type 1 Transmitted Drug Resistance among Treatment-Naive Individuals Residing in Jakarta, Indonesia

Khairunisa

Megasari

Rahayu

et al. 2020

Infectious Disease Reports

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View full text Add to dashboard Cite

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“…Recent study reported high prevalence of HIV transmitted drug resistance and moderate prevalence of acquired drug resistance among PLHIV residing in Buleleng, Bali, Indonesia. Drug resistance reduces the effectiveness of ART in suppressing HIV replication [22], [23]. This issue should be taken into consideration to delivered appropriate treatment in both ART-naive and ART-experienced individuals, especially when HHV-8 infection present.…”

Section: Discussionmentioning

confidence: 99%

The Emergence of HHV-8 Infection among HIV-positive Individuals Residing in Bali, Indonesia

Megasari

Oktafiani²,

Soetjipto

2022

Open Access Maced J Med Sci

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Background: Human herpesvirus 8 (HHV-8) is considered as the etiological agent of Kaposi’s sarcoma (KS). In people living with human immunodeficiency virus (HIV) (PLHIV), KS defines acquired immunodeficiency syndrome (AIDS). Previous study found that HIV-positive individuals were more likely to be HHV-8 seropositive than HIV-negative individuals. Reports regarding the presence of HHV-8 and HIV co-infection in Indonesia is severely limited. Aim: This study aimed to identify HHV-8 infection among HIV-positive individuals in Bali, Indonesia. Materials and Methods: Forty three plasma samples were collected from 16 antiretroviral therapy (ART) naive and 27 ART-experienced individuals residing in Buleleng Regency, Bali, Indonesia. Detection of HHV-8 antigen was performed by using ELISA method. The Fisher's Exact test and the Spearman correlation test would be used to analysed data accordingly. Results: Seven samples (7/43, 16.3%), one of ART-naive individual (1/16, 6.25%) and six of ART-experienced individuals (6/27, 22.2%), were tested positive for HHV-8 antigen. Human herpesvirus 8 infection was correlated neither to sex (p=1.000) and age (p=0.716), nor to ART status (p=0.178) and length of ART (p=0.465). Conclusion: This study indicates the emergence of HHV-8 infection among HIV-positive individuals residing in Bali, Indonesia. Sufficient diagnosis of HHV-8 should be considered for all HIV-positive individuals in order to deliver appropriate treatment. Extensive researches is suggested to be conducted in more regions of Indonesia in order to determine the magnitude of HHV-8 infection among HIV-positive individuals.

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Genotypic Characterization of Human Immunodeficiency Virus Type 1 Isolated from Antiretroviral Treatment-Experienced Individuals in Buleleng Regency, Bali, Indonesia

Abstract: Genotypic characterization of human immunodeficiency virus type 1 isolated from ARTexperienced individuals in Buleleng Regency,

Cited by 2 publications

References 10 publications

Detection of Human Immunodeficiency Virus Type 1 Transmitted Drug Resistance among Treatment-Naive Individuals Residing in Jakarta, Indonesia

Detection of Human Immunodeficiency Virus Type 1 Transmitted Drug Resistance among Treatment-Naive Individuals Residing in Jakarta, Indonesia

The Emergence of HHV-8 Infection among HIV-positive Individuals Residing in Bali, Indonesia

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