Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus

Shaat, Nael; Ekelund, Magnus; Lernmark, Åke; Ivarsson, Sten; Nilsson, Astrid; Perfekt, Roland; Berntorp, Kerstin; Groop, Leif

doi:10.1007/s00125-004-1388-5

Cited by 51 publications

(11 citation statements)

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“…In the present study, Arab women were characterized by insulin resistance, which, in contrast to our previous findings [14], was no longer apparent after adjustment for BMI. The results of these two studies are not completely comparable since a higher 2-hour cut-off was used in the previous study to define GDM, and furthermore, it was based on data obtained during pregnancy, i.e.…”

Section: Discussioncontrasting

confidence: 99%

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The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus

et al. 2013

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The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus.Ignell, Claes; Shaat, Nael; Ekelund, Magnus; Berntorp, Kerstin Link to publication Citation for published version (APA): Ignell, C., Shaat, N., Ekelund, M., & Berntorp, K. (2013). The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus. Acta Diabetologica, 50(6), 927-934. DOI: 10.1007/s00592-013-0484-8 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. (17)Claes Ignell ⋅ Nael Shaat ⋅ Magnus Ekelund ⋅ Kerstin Berntorp -5 ). In addition to BMI, non-European and Asian origin was associated with the development of diabetes after GDM in a multivariate logistic regression analysis, whereas Arab origin was not.Our results highlight the importance of preventive measures to ensure a healthy lifestyle in women with GDM, particularly in high-risk ethnic groups.

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Section: Discussioncontrasting

confidence: 99%

“…This may partly be explained by differences in insulin secretion and action [9][10][11][12][13]. We have previously shown that Arab women with GDM are more insulin resistant during pregnancy than Scandinavian women [14]. This finding stimulated our interest in further studies.…”

Section: Introductionmentioning

confidence: 95%

The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus

et al. 2013

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“…After screening the full-text of the papers, we excluded 34 from the study because they were functional studies or presented duplicate data sets or they did not supply sufficient data about HLA polymorphisms. In our analysis, we finally employed a total of 16 studies 11 13 15 16 17 18 19 21 22 23 24 25 26 27 28 29 and their characteristic features are summarized in Table 1 . The flow of our study is illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The link between DQ6 and GDM was discernible in two Swedish populations and one Chinese population 15 19 21 . However, studies of other populations have provided conflicting results that both supported and dismissed the DQ6 link with equal frequencies 11 18 22 24 25 27 28 . Using meta-analysis, we have identified that DQ6 is nominally associated with the etiology of GDM (OR = 0.81, 95% CI = 0.69–0.94) and this association remains significant even when we removed any of the publications included in this study.…”

Section: Discussionmentioning

confidence: 99%

The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: A meta-analysis

Guo

Jin

Lee

et al. 2016

Sci Rep

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Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is associated with an increased risk of pregnancy complications. Susceptibility to GDM is partly determined by genetics and linked with type 1 diabetes-associated high risk HLA class II genes. However, the evidence for this relationship is still highly controversial. In this study, we assessed the relationship between HLA class II variants and GDM. We performed meta-analysis on all of literatures available in PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval of each variant were estimated. All statistical analyses were conducted using the Comprehensive Meta Analysis 2.2.064 software. At the allelic analysis, DQB1*02, DQB1*0203, DQB1*0402, DQB1*0602, DRB1*03, DRB1*0301 and DRB1*1302 reached a nominal level of significance, and only DQB1*02, DQB1*0602 and DRB1*1302 were statistically significant after Bonferroni correction. At the serological analysis, none of DQ2, DQ6, DR13 and DR17 was statistically significant following Bonferroni correction although they reached a nominal level of significance. In sum, our meta-analysis demonstrated that there were the associations between HLA class II variants and GDM but more studies are required to elucidate how these variants contribute to GDM susceptibility.Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset during pregnancy 1 . The manifestation of GDM is reportedly influenced by age 2 , ethnicity 3 , BMI 4 , and family history of GDM of the pregnant woman 5 . Despite all this information, the pathogenesis of GDM still remains obscure. Since GDM is regarded as a risk factor for developing type 2 diabetes 6 , many investigators have mainly focused on the linkage between GDM and type 2 diabetes. However, Lapolla et al. 7 reported that presentation of pancreatic islet autoantibodies during GDM is predictive for type 1 diabetes development. A number of studies have demonstrated that the circulating immune markers of type 1 diabetes (such as anti-islet cell antibodies and anti-GAD antibodies) are present in the blood of pregnant women with GDM [8][9][10][11] . There is no doubt that we could understand the pathology underlying GDM better, if more genetic risk variants that are shared by type 1 diabetes and GDM were identified. The major type 1 diabetes susceptibility variants are HLA class II genes located on chromosome 6p21, which account for up to 30-50% of the heritability of type

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“…So far, genetic predisposition to GDM has been reported for variations in genes involved in insulin resistance and insulin secretion. However, no association could be replicated in different studies [21–23]. These discrepancies could be due to lack of power, given the small effect size of most common variants, or to ethnic heterogeneity among different populations.…”

Section: Discussionmentioning

confidence: 99%

Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

Alharbi

Khan

Abotalib

et al. 2014

BioMed Research International

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Pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share a common pathophysiology associated with similar risk factors. Genetic variants used to determine the risk of developing T2DM might also be associated with the prevalence of GDM. The aim of the present study was to scrutinize the relationship between the G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene with GDM in the Saudi female population. This is a case-control study that monitored 500 Saudi women. Subjects with GDM (n = 200) were compared with non-GDM (n = 300) controls. We opted to evaluate rs1801278 polymorphism in the IRS1 gene, which plays a critical role in the insulin-signaling pathway. Genotyping was performed with the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The frequency of the rs1801278 polymorphism was significantly higher in women with GDM than in women with non-GDM (for TT + CT versus CC: P = 0.02). Additionally, there was a significant increase in the frequency of the Arg-encoding mutant allele from GDM to non-GDM (for T versus C: P = 0.01). Our results suggest that the rs1801278 polymorphism in the IRS-1 gene is involved in the occurrence of GDM in the Saudi population.

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Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus

Cited by 51 publications

References 50 publications

The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus

The impact of ethnicity on glucose homeostasis after gestational diabetes mellitus

The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: A meta-analysis

Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

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